Post Tag: Health

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PT369 – Chronic Pain and Phantom Limb Pain: Could Psilocybin Be the Answer?

In this episode, Joe invites Court Wing to co-host, interviewing two members of UC San Diego’s Psychedelics and Health Research Initiative (PHRI): Joel Castellanos, MD (Associate Medical Director of PHRI and board-certified physical medicine and rehabilitation and pain medicine physician), and Timothy Furnish, MD (Medical Director of PHRI and Associate Clinical Professor of Anesthesiology and Pain Medicine). 

As one of the early participants of a psilocybin-for-depression trial in NYC, Court Wing (of REMAP Therapeutics) discovered that immediately after the session, his chronic pain had miraculously gone away. He began researching how psychedelics could be used (with or without other therapies) to continue the alleviation of pain psychedelics had brought him. Through the Psychedelics and Health Research Initiative, Drs. Castellanos and Furnish are following that that same road, and are currently recruiting for a randomized controlled trial on psilocybin for phantom limb pain. 

They talk about the relationship between the mind and chronic pain: how people confuse pain with the simple act of nerves firing, but how it’s so much more. And they discuss how pain can become part of one’s identity (and how the Default Mode Network could be contributing); how physical therapy is related to neuroplasticity; mirror box therapy; microdosing for chronic pain; the unusual nature of phantom limb pain; and where the mystical psychedelic experience may come into play. If this topic is as fascinating to you as it is to us, stay tuned – we will be featuring much more on chronic pain and psychedelics, including a blog series from Court Wing coming soon.

Notable Quotes

“One of the things that may be unique about or interesting about chronic pain is that the longer it goes on, the more people start seeing pain as a part of their identity and that Default Mode Network is probably playing a role in that. And it’s possible that something like psychedelics could open up the possibility of changing that internal story so that pain is no longer so much a part of one’s identity.” -Tim

“I think that people oftentimes confuse pain with simply nerves firing. …[But] there is this rich interplay between the way we think about pain, the way we perceive pain, and how we feel about it.” -Tim

“When you’re not really dealing with chronic or severe pain on a daily basis, it’s really hard to think about how life-changing that is or can be.” -Joel

“When we hear things like ‘It’s only just in your head,’ I don’t think people quite get [that] the head can be a scary place to be trapped sometimes.” -Court

Links

PHRI.ucsd.edu: Psychedelics and Health Research Initiative at UC San Diego

REMAPtherapeutics.com

Psychedelics Today: Court Wing – Pain and Its Relationship to the Mind

Pubmed: Chronic pain and psychedelics: a review and proposed mechanism of action

Sciencedirect.com: Mirror Visual Feedback Therapy. A Practical Approach

Psychologytoday.com: Catastrophizing

Physio-pedia.com: Kinesiophobia

Sinobiological.com: What is tumor necrosis factor (TNF)

Neuropathycure.org: Cryoneurolysis: A Freezing Cold Way To Treat Chronic Nerve Pain

Journals.lww.com: Microdosing psilocybin for chronic pain: a case series

Clusterbusters.org

Clinicaltrials.gov

Healthgrades.com: Diagnosing and Treating Anhedonia: Loss of Pleasure Explained

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PT368 – Ketamine, Group Work, and the Power of Just Being There

In this episode, Kyle interviews Dr. Steven Radowitz: Medical Director at Nushama, a wellness center in New York City primarily offering IV ketamine, with a strong focus on letting the experiencer explore their journey undisturbed. 

Recorded in-person at Nushama’s flagship location just over a year after opening, Radowitz talks about his past and why he became interested in ketamine, the look and feel of Nushama, their process, and why they favor IV ketamine. He highlights his biggest takeaways from the year: the surprise in just how effective ketamine has been; the role of integration and what aftercare truly looks like; and the importance of learning to hold space and be a compassionate listener – that the doctor isn’t the healer and the psychedelic isn’t the magic bullet cure; instead, they are just tools that allow the patients to heal themselves.  

He discusses how he sees psychedelics as a dimmer switch for the ego; how disorders are tools to deal with trauma; why he is reframing trauma as a learning experience; why he thinks ketamine will survive once psilocybin and MDMA are legal; why group work is so effective and powerful (and likely the new model for psychedelic therapy); and the importance of staying humble through all of this – humble to the power of the medicine and humble to the amazing capacity for people to heal and grow, simply by being allowed to explore their journey and be heard.

Notable Quotes

“I’m not a healer, and I often tell people [that] during their preparation, when I do my medical intake. I talk to them about that. I say, ‘I’m not here [to heal you], I’m here just giving you a tool. You’re the healer. All this stuff does is [that it] just takes away what’s blocking you from realizing that. It’s like a dimmer switch on the ego [and] on the mind.”

“I’m trying to move away from the word ‘trauma.’ It’s a difficult life event that’s there to teach us. It’s there for something. And with every one of those events; there’s a little jewel within it, but you have to go in there and go through it. And it’s just a cloud, just a myst, almost, that’s preventing you. Just push [through it] and hold space. As long as people are in a safe place to go there and journey there, then they’ll realize that it’s just an event. It’s just an experience, and you move on. That wisdom is: a memory without the emotion.”

“I think any type of journey work, any type of psychedelic work, I almost think you have to be called to it in a way. You shouldn’t be coerced, ever, into this. …I find that the ones that are really ready to do the work are finding us on our own.”

Links

Nushama.com

Wavepaths.com

Rootstothrive.com

Kyle and Dr. Radowitz at Nushama
Nushama’s office, courtesy of Nushama and Costas Picadas
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PT365 – KAP: Self-Agency Through Intention, Titration, and Ceremony

In this episode, Kyle interviews Dr. Jennifer Montjoy: Tucson, Arizona-based psychiatric nurse practitioner with a private practice specializing in ketamine-assisted psychotherapy, and Medical & Research Director at TRIPP (Transpersonal Research Institute of Psychotherapeutic Psychedelics); a 501(c)(3) organization that provides psychedelic training and research opportunities largely for female and BIPOC scientists.

A Vital student introduced Kyle to Montjoy’s research on ketamine and PTSD and presented with her at the recent ICPR conference in Amsterdam, where this was recorded in-person (as Kyle and Johanna were there, representing Psychedelics Today). Montjoy talks about her protocol, the self-transcendent scale she’s using with clients pre- and post- induction, how ketamine can help people get over past trauma through shifts in emotional memory, and what she sees most in successful cases: a gradual shift toward self-agency.

She discusses how integral titration is to her process; how ACE (adverse childhood experience) scores work; how dissociation can help with childhood trauma; how clients often naturally fall into using Internal Family Systems to describe their process; and how physicians and therapists shouldn’t be afraid of the concept of ceremony and opening sessions with intention – and, as she likes to say, giving one’s mind coordinates on where it can end up.

Notable Quotes

“I do think it’s helpful to have a skillset and general understanding of that so you know what’s happening in real time, but for the most part, I subscribe to the philosophy that we all have an inner healer. We all have that inner wisdom, but most of us don’t have access to it because we have these managing protectors from our trauma.” 

“Often [for the] opening, I’ll ask the higher self to step into the light, to take the reins and let all those parts know that the goal here is not to annihilate or bypass them. That’s the language I consistently use in opening, because as the facilitator, we want to align with those parts too. We’re not the enemy.”

“Don’t be afraid to incorporate ‘ceremony.’ …I think that makes a lot of physicians maybe uncomfortable; that idea. [But] opening and closing [the ceremony] can be very helpful tools, [and] making sure we’re asking about intention before each session. I call that the coordinates, because we want to give the unconscious mind the coordinates.”

Links

Jenmontjoy.com

Resiliencetucson.com

TrippAZ.org: The Transpersonal Research Institute of Psychotherapeutic Psychedelics

Resiliencetucson.com: 4-Day Experiential Training in Ketamine-Assisted Psychotherapy For Clinicians

Psychedelics Today: Ketamine and Trauma Treatment

Ncjfcj.org: Finding Your ACE Score

Psychedelics Today: PT300 – Dr. Richard C. Schwartz – Vital Psychedelic Conversations

Psychedelics Today: Veronika Gold – Methods of Ketamine Assisted Psychotherapy

Biomedcentral.com: Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new anthelmintic?

Dr. Montjoy and Kyle recording at the The Interdisciplinary Conference on Psychedelics Research (ICPR) in September

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PT335 – Christopher Dawson & Andrew Galloway – Modernizing Traditional Plant Medicine With Neuroscience and Luxury

In this episode, Joe interviews Christopher Dawson & Andrew Galloway: Co-Founders and CEO and COO, respectively, of Dimensions; a Canadian-based company creating retreats that blend traditional plant ceremonies with neuroscience and a luxurious, five-star environment.

Dawson realized what so many people were starting to learn about psychedelics after attending a 2015 conference in Peru that mixed neuroscientists with traditional healers, but for Galloway, it was direct experience, as he gives credit to plant medicines for helping him to heal from a 6-year addiction to crack cocaine. They each tell their story and how it led to the beginnings of Dimensions, where they worked for a year with a “Dreamlab” team of MDs, psychiatrists, practitioners from different fields, and even a design agency to create different programs for different substances – all with a focus on true set and setting and integrating perfectly with nature. They’re in the middle of a soft launch right now, offering cannabis in a ceremonial, group setting context to friends and families at their Algonquin Highlands location; perfecting everything before opening up to the general public. And once the law catches up with them, they hope to offer psilocybin and other psychedelic-assisted therapy across several new retreat locations. 

They talk about Health Canada and the country’s trajectory towards legal psychedelics; critiques of traditional addiction treatment and the efficacy of 12-step programs; the tension between the psychedelic space and traditional healing space; investing in biotech; the polyvagal theory; how animals deal with trauma (and how we don’t); and the concept of integration: If you’re just taking a pill and not doing the work, are you missing the point entirely?

Notable Quotes

“We’re biased (we’re in the retreat business), but I don’t think that psilocybin, as an example, should be reduced to a pill that you take with your juice in the morning and you no longer take your SSRI because this is your new pill. For us, it’s the psychedelic-assisted therapy that actually maximizes the potential of the psychedelic experience, and that’s the mechanisms through which fundamental, behavioral change can take place. I think the idea that a pill can replace all of that means that you’re kind of missing the point about the whole experience.” -Chris

“I don’t want to slam traditional treatment because it actually did work for me to some degree. …I had a crack-cocaine addiction for six-seven years and ended up in rehab for six months and came back and participated in 12-step programs and remained abstinent. That part worked. The difference for me when I got involved with plant medicine was something else: I got healed. Instead of just abstaining and not using to cope or to manage with whatever I was dealing with, I actually healed through plant medicine.” -Andrew

“Is it a pill or is it the therapeutic process? If you don’t engage in integration, then you’re just taking a pill.” -Chris

“We talked about stigma earlier; it’s changing, and [for] the general public, the stigma around the war on drugs is changing too. I think people have finally figured out that it doesn’t work. No war works. We only declare war on things that we can make money from.” -Andrew

Links

Dimensionsretreats.com

Dimensionsretreats.com: Algonquin Highlands

Psychedelics Today: PT314 – Daniel McQueen, MA – Vital Psychedelic Conversations

Psychedelics Today: Canada’s SAP Expansion Signals a Step Forward for Psychedelics

Dimensionsretreats.com: Dimensions + Queen’s University

Thedesignagency.ca

National Library of Medicine: Psychedelic perceptions: mental health service user attitudes to psilocybin therapy

Somaticmovementcenter.com: What is the Polyvagal Theory?

Psychedelics Today: PT248 – Pierre Bouchard – Somatic Therapy, Trauma, and the Nervous System (more about the polyvagal theory)

Psychedelicmedicinecoalition.org

About Christopher Dawson

Christopher Dawson is the Co-Founder and CEO of Dimensions, a growing collection of retreat destinations combining neuroscientific research with plant ceremony in immersive natural environments. Prior to co-founding Dimensions, Christopher was the founder and CEO of Edgewood Health Network, where he oversaw the largest private network of residential/outpatient treatment providers in Canada and led the merger and acquisition of Canada’s top three treatment centers to create that network.

 

About Andrew Galloway

Andrew Galloway is the Co-Founder and COO of Dimensions, a new paradigm for healing, combining ancient ceremonial plant medicines with modern science in safe, legal, and nurturing natural environments. He leads the organization’s clinical teams and operations for Dimensions Retreats, a new collection of immersive, transformational healing retreats combining neuroscientific research with plant ceremony and luxurious hospitality. Prior to co-founding Dimensions, he was a National Director of Edgewood Health Network; leading 10 outpatient centers. Andrew was the former VP at GreeneStone Muskoka, an international certified alcohol and drug counsellor, and has 14 years of experience working directly for the NHL/NHLPA substance abuse program.

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PT334 – Prof. David Nutt – The Human Brain, Addiction, and Telling the Truth About Drugs

In this episode, recorded in-person at the recent From Research to Reality summit, David interviews one of the more well-known figures in the psychedelic space (who somehow hasn’t been on the show yet), David Nutt: Psychiatrist, Founder and Chief Scientific Officer at Drug Science, Chief Research Officer at Awakn Life Sciences, and Edmund J. Safra Professor of Neuropsychopharmacology in the Division of Brain Science, Dept of Medicine, Imperial College London.

At Awakn Life Sciences, amongst other projects, Nutt is working to set up clinics for legal psychedelic therapy (so just ketamine for now), and, after a successful study on MDMA in the treatment of alcohol use disorder, he’s doing something nobody has really done before in seeing if improvements can be made to MDMA. He tells the story of when he was fired as chair of the Advisory Council on the Misuse of Drugs due to telling the truth about the differences in harm between alcohol, tobacco, and “bad” drugs like LSD and cocaine, which led to the birth of Drug Science (and embracing the truth about drugs even more).

He covers a lot of ground in this episode: how serotonin seems to affect the default mode network; glutamate, cortexes, and the flexibility in the human brain; Robin Carhart-Harris’ “Trial of Psilocybin versus Escitalopram for Depression” study and the realization that psychedelics were doing something different in the brain; Measure 109 and the importance of how Oregon establishes a new paradigm around legal mushrooms; drug hysteria in the US and UK and how drastically that differs from Portugal’s incredibly successful approach to drugs; why real world evidence is the core of science; and why psychedelics seem best at disrupting internalizing disorders.

Notable Quotes

“The reality is that the psychedelic impact on depression has been so powerful, it’s changed the whole narrative about how we think about depression. Our one study in [treatment]-resistant depression spawned 40 companies now [that] are working on psilocybin for depression, which is amazing. …It’s been a spark to this amazing expansion. Why? Because for the last 40 years, there’s not been any innovation in terms of mechanisms in treating depression, ever. All the drugs we have today are essentially safer derivatives of the drugs we invented in the 1950s. So this is a new approach, and that’s really, really exciting.”

“We’ve got to get our politicians, our policymakers to admit that these drugs should never, ever have been put in Schedule I. They were put in Schedule I [because] we said they were ‘very harmful’ (which they’re not), and they have no medical value (which they do), and it’s actually immoral now, reprehensible that politicians could not see that.”

“They just said, ‘Let’s try a different approach. Let’s try decriminalization and let’s treat drug addicts as human beings and help them get off the addiction rather than put them in prison.’ And that’s been one of the greatest success stories in the history of drug interventions. In the 15 years we have data since the Portuguese experiment was instigated, the Portuguese have reduced opiate deaths to one third of what they were before. In the same 15 years in Britain, using prohibitionist policies, we’ve doubled our deaths from opiates. And that, frankly, is an insult to humanity that we’ve pursued policies which we know are actually killing people.”

“Real world evidence is the core of medicine.” 

Links

Drugscience.org.uk

Drug Science podcast

​​Awaknlifesciences.com

Imperial College London

Journals.sagepub.com: First study of safety and tolerability of 3,4-methylenedioxymethamphetamine-assisted psychotherapy in patients with alcohol use disorder

New England Journal of Medicine: Trial of Psilocybin versus Escitalopram for Depression

Psychedelics Today: Op-Ed: Re-evaluating the Results of the Recent Trial of Psilocybin vs Escitalopram for Depression

Pubmed: Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms

The Alexander Mosley Trust

Parea.science: Psychedelics Access and Research European Alliance

Nature.com: Sacked science adviser speaks out

BBC.com: Alcohol ‘more harmful than heroin’ says Prof David Nutt (with drug harm scale)

EJI.org: Nixon Adviser Admits War on Drugs Was Designed to Criminalize Black People

NPR.org: New York City allows the nation’s 1st supervised consumption sites for illegal drugs

NYTimes.com: How a Man With a Van Is Challenging U.K. Drug Policy

The Drug Science Podcast: #32 – Drug Consumption Rooms, with Peter Krykant

Awaknlifesciences.com: Awakn Finalizes Deal To Acquire Leading Norwegian Ketamine-Assisted Psychotherapy Clinic

About David Nutt

David Nutt is a psychiatrist and the Edmund J. Safra Professor of Neuropsychopharmacology in the Division of Brain Science, Dept of Medicine, Imperial College London. There, he uses a range of brain imaging techniques to explore the causes of addiction and other psychiatric disorders and to search for new treatments. He has published over 400 original research papers, a similar number of reviews and books chapters, eight government reports on drugs, and 36 books, including one for the general public, Drugs: Without The Hot Air, that won the Transmission Prize in 2014.

He is currently the President of the European Brain Council and Founding Chair of Drug Science. Previously he has been president of the British Association of Psychopharmacology, the British Neuroscience Association, and the European College of Neuropsychopharmacology. He broadcasts widely to the general public both on radio and television. In 2010, The Times Eureka science magazine voted him one of the 100 most important figures in British Science, and the only psychiatrist in the list. In 2013, he was awarded the John Maddox Prize from Nature/Sense about Science for standing up for science.

Socials:
Twitter: David Nutt / Drug Science / Awakn Life Sciences

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PT332 – James Lanthier – Patentability, Capitalism, and The Next Generation of Psychedelics

In this episode of the podcast, Joe interviews the CEO of Mindset Pharma, James Lanthier.

Mindset Pharma is a 3-year old biotechnology company built on discovering and developing new psychedelic compounds to be used as medicine for a variety of indications. While the efficacy of the psychedelics we know can’t be denied, the goal of science is to improve, and Lanthier believes optimizing these drugs will make them safer, more predictable, and more palatable for a far greater portion of the population. He envisions these new molecules leading to a future of highly personalized medicine, where people who would never eat a mushroom would likely take a related drug prescribed by their doctor.

Lanthier discusses what’s going on at Mindset Pharma; why patents alone will not be sufficient protection from competition; the long game of biotech, psychedelic stocks, and overreaction to slow growth; the Nagoya protocol; mescaline; the need for big pharma and capitalism; the art of formulation; and how microdosing could soon be revolutionized. 

Notable Quotes

“I had some fairly well-known psychedelic investors say to me, ‘You’re just building a better mousetrap.’ And my reaction was: ‘Well, that’s the march of science. That’s what science is trying to do.’ Take the example of what the German scientist [Felix Hoffman] did in the nineteenth century to go from the bark of the willow tree, eventually going through a whole bunch of intermediate chemical steps to eventually get to Aspirin. Science hopefully tries to make things better, and that’s what we’re trying to do.”

“Big pharma has skipped right past psilocybin. Why? In my view, it would be because of the lack of strong IP rights. They’ve gone right to second and third generation drugs because they’ve made the assessment that even if you own the strongest IP in the psilocybin space, you’re still quite exposed, ultimately, to competition.”

“I think if there’s a future where you have relatively low-priced classic drugs potentially available alongside more optimized, specific drugs that have the full support of the medical community, that would be a great place to get to, I think – really great place to get to. And I think we only really get there with the machinery of capitalism moving forward.”

Links

Mindsetpharma.com

Otsuka-us.com (Otsuka Pharmaceutical)

Sciencehistory.org: Felix Hoffman

YouTube: Dr. Stanislav Grof, “Psychedelics and the Future of Humanity”, MAPS Psychedelic Science 2017

Protests for Right to Try (sent to us by Kathryn Tucker)

Nagoya Protocol

About James Lanthier

James Lanthier is the CEO of Mindset Pharma, and is a seasoned technology executive with strong expertise in corporate finance, public markets and M&A. Most recently, Mr. Lanthier was a co-founder and CEO of Future Fertility, an innovative early stage developer of AI applications for human infertility. As a C-Suite executive, Mr. Lanthier has assisted in the growth and successful exit of numerous technology-enabled businesses through the public markets, including Mood Media, the world’s largest in-store media provider, and Fun Technologies, a pioneer in online casual games.

Socials: Linkedin

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PT331 – Julie Zukof & Dr. Michelle Weiner – Psychedelic Women, Coaching, and Ketamine For Fibromyalgia

In this episode, Joe interviews Julie Zukof: Head of Strategic Partnerships for Nue Life and the creator of Psychedelic Women, and Michelle Weiner: a double board-certified Doctor specializing in integrative pain management, using cannabis, ketamine, and other holistic modalities to get to the root cause of chronic pain.

Weiner tells of how her pain-management methods changed as her patients told her about the healing power of cannabis and ketamine, and how she was even more inspired by learning how much chronic pain is a result of fight-or-flight trauma reactions and resulting learned behavior. She discusses the central sensitization of fibromyalgia; ketamine infusions and dose discovery; the differences between how therapists and coaches are viewed (and the need for both); session music and trusting the facilitator in their music choice; and the importance of preparing for a ketamine experience through meditation and/or breathwork. 

And they talk about Psychedelic Women, which was just founded in January as a result of Zukof realizing how much women were a minority in the psychedelic space. She talks about why we need more women in psychedelia; women’s natural inclination to connect and support each other; and how medicine should mirror that – where people from all methodologies can work together for the betterment of the patient. Psychedelic Women is in the process of updating from a speaker series to a more community-based platform. If you want to become a part of the community, sign up at their waitlist today!

Notable Quotes

“Personally, the coaches and the therapists that I use (my nurse practitioners) are mainly women. And I don’t know if that’s because they gravitate towards this field or because patients gravitate towards them, but there’s that nurturing, innate property of being a woman that also is special and unique and we can use to our advantage in that sense.” -Michelle

“I think people are under the impression that psychedelics are always meant to be enjoyable. And while ketamine oftentimes is enjoyable, sometimes it’s meant to be part of a healing journey.” -Julie

“I credit Dustin [Robinson] for bringing us on and featuring the group at Soho House, and something he said was, ‘It’s not that I don’t want to feature women on the panel, I just need more women in the space to feature them.’ And I think that’s an excellent point. And if we can help do something about that, then I think we’re winning.” -Julie

“There’s so many other people that are involved in making this experience more effective for people. It’s not just the medicine and the doctor and the therapist and the coach. …It’s so nice to see because this is really how medicine should be. It shouldn’t be everybody in their own box like with other physicians. …This whole group is really bringing people together that have certain talents and passions and saying: ‘We can work together.’” -Michelle

Links

Psychedelicwomen.co

DrMichelleWeiner.com

Msha.ke: Julie Zukof

Nue.life

Spinewellnessamerica.com

Citybiz.co: Dustin Robinson Presents Psychedelic Women Panel, Part of the Monthly Psychedelic Series at Soho Beach House Miami on Jan. 17

Psychiatryadvisor.com: Pain Reprocessing Therapy Reduces Pain Perception, Disability in Chronic Back Pain

Wavepaths.com

Psychedelics Today: PTSF 41 (with Mendel Kaelen of Wavepaths)

Chief.com

Heymama.co

Dreamersdoers.com

“Psychedelics & Pain Symposium” event by REMAP Therapeutics (this event is tomorrow!)

Stanford Psychedelic Science Group

UC San Diego: Psychedelics and Health Research Initiative

About Julie Zukof

Julie Zukof is the creator of Psychedelic Women, a speaker series and influential community. Over her eighteen year career in NYC, Julie has created, innovated, marketed, and grown wellness brands by working at prestigious innovation firms and then starting her own consultancy. Julie is now Head of Strategic Partnerships for Nue Life, the leading mental wellness company in at-home ketamine treatments.

 

Socials:

Instagram / Linkedin

 

About Dr. Michelle Weiner, DO MPH

Dr. Michelle Weiner is double board-certified in Interventional Pain Medicine and Physical Medicine and Rehabilitation, and a partner in private practice at Spine and Wellness Centers of America. She is a member of Florida’s Medical Cannabis Advisory Committee, vice president of Mr. Psychedelic Law, a not-for-profit with the mission of responsible legal reform of psilocybin, and a clinical advisor for Iter Investments, a venture capital firm focused on supporting emerging companies within the psychedelic ecosystem of behavioral and mental health. Dr. Weiner’s research focuses on using cannabis as a substitute for opioids in chronic pain patients and cannabis’s effect on seniors with chronic pain, as well as comparing psychedelic v psycholytic doses of ketamine for chronic pain and depression. Her unique approach of personalized and preventative medicine focuses on empowering her patients to cultivate health using cannabis and ketamine-assisted psychotherapy as a catalyst to identify the root cause of one’s suffering, optimizing their quality of life.

Socials: Instagram 

 

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PT330 – Dick Simon – Researching Ethnobotanical Efficacy and the Search For New Therapeutic Molecules

In this episode, Joe interviews Co-Founder and CEO of Sensorium Therapeutics, Dick Simon. 

Sensorium Therapeutics was created by professionals from Massachusetts General Hospital who started to wonder: With so many plants with rich, ethnobotanical history, what if we looked to those plants for answers instead of just analyzing the trendy psychedelics so many are focused on now? Why not fully research what already has established efficacy? Their goal is to have the largest collection of psychoactive plants (which they’re calling their Neuro-Natural Library), and use machine learning to figure out exactly which molecules are doing what, to then synthesize new drugs that are safe and effective; eventually bringing these new compounds through the FDA approval process.  

Simon talks about how so much of what we know to be effective and beneficial is based on assumptions or best guesses, and while that doesn’t discredit very real benefits, it does beg the question: Is this all optimized as best as it could be? 

He also discusses how recent advances in neuroscience and technology are catalyzing molecular research; how we can learn about other mental health indications from studying rumination; the benefits and challenges of nutraceuticals; geopolitical conflict resolution; organoids; the necessity of the FDA; why “them” can be a very dangerous word; the challenges of benzodiazepines; Burning Man; and the problem with people needing to be treatment-resistant or seriously ill to gain access to psychedelics. He hopes that what Sensorium Therapeutics learns over the coming years will help bring better medicines to more people.

Notable Quotes

“The goal here is to look at the 500+ plants and fungi and what their component elements are (what’s actually driving that efficacy, or signals of efficacy; signals that they make a difference in a high throughput way), to really assemble massive data. Then, we’re using machine learning to distill all that down to: ‘Alright, we have all this cool information; what does it mean? What does it tell us? And how do we convert that into a drug that helps people?’”

“We operate under a lot of assumptions that are based on experience, but are not based on any controls on the experience. Even something basic like the assumption [that] music and playlists are really important – they’ve been used and they seem to work. We don’t really know if that’s true. …I’m not saying that music and a controlled playlist isn’t absolutely the best answer, but it seems like it’s something we really ought to know an answer to, rather than make assumptions.”

“If I would have told someone ten years ago: “No, no, we’re going to have this company, Sensorium, and it is going to be able to, in a 384-well plate, take a look at groups of neurons growing, and we’ll have sophisticated microscopy to take a look at it, and we’ll be able to do it at a high throughput basis, and we can reliably do it and replicate,’ the question would have been: ‘Alright, what other drugs are you taking? That’s not going to [happen].’ [But] we’re there.” 

“Even questions as to how important the psychedelic effect is to efficacy; the assumption tends to be that somehow or another, the intensity of the experience is related to the efficacy. …There are people now who are looking at: ‘What if you removed the psychedelic effect from psychedelics? Are you still getting the same neuroplasticity, neurogenesis, and much of the effect?’ I don’t know the answer, but I think those that are ideologues on either side of that [are] silly. Let’s figure it out. …Why don’t we find the answer rather than argue for whatever our position is?”

Links

DickSimon.com

Sensorium.bio

Sensorium Therapeutics Team

Massachusetts General Hospital Center for the Neuroscience of Psychedelics

YPO.org

Ethnopharmacologic Search for Psychoactive Drugs (Vol. 1 & 2): 50 Years of Research, edited by Dennis McKenna

Psychedelics Today: PT245 – Robin Carhart-Harris – Psychedelics, Entropy, and Plasticity

Thehill.com: Activists Demanding Psilocybin for Terminally Ill Patients Arrested Outside DEA Headquarters

The Nagoya Protocol on Access and Benefit-Sharing

Dick Simon Ted Talk: ”The Most Dangerous Four Letter Word: Them”

Texastribune.org: Rick Perry returns to the Texas Capitol to pitch study of psychedelic drugs for PTSD in veterans

An Intellectual History of Psychology, by Daniel N. Robinson

Bostonpsychedelicresearchgroup.com

Sunstonetherapies.com

About Dick Simon

Dick Simon is a serial entrepreneur and leader in advancing psychedelic-assisted therapies. He is the Chairman of the Advisory Council of Center for the Neuroscience of Psychedelics at Massachusetts General Hospital, Co- Founder and Board Member of the Boston Psychedelic Research Group, and on the steering committee for the Psychedelic Science Funders Collaborative. He received his undergraduate degree from Cornell University and his MBA from Harvard Business School. After September 11, 2001, he co-founded and led the YPO Peace Action Network which leverages personal and business relationships, resources, and expertise for conflict resolution on local and global levels. Dick’s work has earned him YPO’s Global Humanitarian Award, Harvard Business School’s Making a Difference Award, inclusion in Real Leaders magazine’s “100 Visionary Leaders” and in the “100 Most Influential People in Psychedelics” list.

Socials: Instagram / Twitter / Facebook / Linkedin

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PT329 – Dr. Scott Shannon – The Board of Psychedelic Medicine and Therapies

In this bonus episode, Kyle interviews Dr. Scott Shannon: psychiatrist, Founder of Wholeness Center in Fort Collins, CO, and Co-Founder and CEO of the Board of Psychedelic Medicine and Therapies (BPMT); a non-profit public benefit corporation which was recently created to certify healthcare professionals in psychedelic-assisted psychotherapy – and which was just in the news last week when they received a $900,000 matching grant from the Steven & Alexandra Cohen Foundation.

Shannon feels that the majority of people who are interested in (and could benefit from) psychedelics would prefer that their experience be as close to a conventional medical setting as possible. And especially with the risks of rogue practitioners, licensing boards want to see predictability, uniformity, regulation, and (perhaps most importantly) that we as a psychedelic culture are placing importance on being accountable and self-governing. He wants to establish a certification process that’s standard enough that which medicine the patient is using will become secondary. 

He discusses what the certification process will likely look like; why uniformity is so important; the challenges of respecting and integrating Indigenous traditions into a medical model that’s drastically different; what people should look for in psychedelic education; and the importance of breaking from a siloed and hierarchical model into one that’s cross-disciplinary, where professionals of all types can work together for the betterment of the patient.

Notable Quotes

“The premise of the certification board is that we’re trying to certify a process …of medication-assisted, psychedelic-assisted psychotherapy that looks at integration [and] prep, that looks at set and setting, that looks at the sacred container of this relationship; and that we build that, and that is the core of it, and the medications become a little bit secondary. We can bring ketamine in, we can bring DMT in, we can bring psilocybin [in], [and] we can bring MDMA in; because these medications, frankly, they’re not really chemically-related or that similar, but what’s similar is the process that patients go through with them.”

“There’s always the question of: ‘How do I get training?’ …The Psychedelic Science Funders Collaborative just did a survey of the field of education and found that there are now over 50 providers of psychedelic education, and four years ago, there might have been a handful. But someone coming [up]: What do they do? ‘How much do I need to study?’ These things are expensive. It’s confusing. So we want to create a clear, professional path [where] someone says: ‘I’m going to step into this and do this as a career. Here’s what I need to do? Good. I can do that.’”

Links

Psychedelicsboard.org (The Board of Psychedelic Medicine and Therapies (BPMT))

BPMT’s press release: Certification Board for Psychedelic Medicine Launches and Receives $900,000 Grant

Wholeness.com (Wholeness Center)

Psychedelics Today: Dr. Scott Shannon – Ketamine Therapies

Pratigroup.org

Businessinsider.com: Johns Hopkins, Yale, and NYU are teaming up to tackle a key bottleneck that will arise as psychedelics come to market

About Dr. Scott Shannon

Scott has been a student of consciousness since his honor’s thesis on that topic at the University of Arizona in the 1970s. Following medical school, MDMA-assisted psychotherapy became a facet of his practice before this medicine was scheduled in 1985. He then completed a Psychiatry residency at a Columbia program in New York. Scott studied cross-cultural psychiatry and completed a child/adolescent psychiatry fellowship at the University of New Mexico. Scott has published four books on holistic and integrative mental health including the first textbook for this field in 2001. He founded Wholeness Center in 2010 with a group of aligned professionals to create innovation in collaborative mental health care.

Scott is a past President of the American Holistic Medical Association and a past President of the American Board of Integrative Holistic Medicine. He serves as a site Principal Investigator and therapist for the Phase III trial of MDMA assisted psychotherapy for PTSD sponsored by Multidisciplinary Association for Psychedelic Studies. He has also published numerous articles about his research on cannabidiol (CBD) in mental health. Scott founded the Psychedelic Research and Training Institute (PRATI) to train professionals in ketamine-assisted psychotherapy and deliver clinically relevant studies. Scott co-founded the Board of Psychedelic Medicine and Therapies in 2021 and currently serves as the CEO for this non-profit public benefit corporation. He lectures all over the world to professional groups interested in a deeper look at mental health issues and a paradigm shifting perspective about transformative care.

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PT327 – Rick Doblin, Ph.D. – Confronting Abuse in Clinical Trials and the Future of Psychedelic Medicine

In this episode, David interviews one of the biggest names in psychedelics and someone we haven’t had on the show until now; Founder and Executive Director of the Multidisciplinary Association for Psychedelic Studies (MAPS), Rick Doblin, Ph.D.

MAPS has recently been at the center of media scrutiny, notably through the New York magazine‘s “Cover Story” podcast series, which chronicled instances of alleged sexual abuse within the MAPS clinical MDMA trials. Since reporting on this issue has largely called into question the design of MAPS’ clinical trials, data reporting, quality control, and claims around the efficacy of MDMA in the treatment of PTSD, we wanted to provide an opportunity for Doblin to respond to these very real concerns – and he does just that.

He discusses how MAPS reacted, what could have been done better, what it has all meant for the non-profit, and how it feels to now be considered the enemy by many in a space MAPS helped build. He addresses the concerns of sessions ending too soon (highlighting how that may suggest a desire for additional therapy) and asks anyone who has participated in a MAPS trial to complete a long-term follow-up survey so the organization can improve their process and ensure their data is as accurate and robust as possible.

He also discusses what the post-approval psychedelic landscape could look like; their goals for facilitator training and how they align with requirements in Oregon; their desire for a patient registry or “global trauma index”; and the importance of collecting and analyzing real-world evidence. And he talks about MAPS and their globalization goals: how exploring psychedelic therapy specifically in countries with little to no tradition of psychotherapy can lead to new therapeutic models. Rather than exploring areas where there is guaranteed revenue, they are seeking areas that are high in trauma instead – to bring these medicines where they are most needed.

Notable Quotes

“I think you can have solutions that go too far. The podcast people put out a solution, saying that there should be no touch in therapy. …They’ve also said that [our] studies should be shut down and that we need experts to think about this for years. I think that kind of thinking is out of balance with the amount of suffering that seems to actually be alleviated.” 

“The more dangerous the drug, the more important it is that it be legal.”

“We’re really wanting to bring this to the police, [and] we’ve done a lot of work with veterans. The breakthrough that we’re still looking forward to one day would be to treat the first active duty soldier. So far, it’s only been veterans, but if we can treat active duty soldiers, I think that would be [great]. The closer you can treat people to the trauma, probably the better.” 

“Even though we’re focused on MDMA and there’s all these other things for MDMA, really, what we’re doing is opening the door to psychedelic medicine. So what we want, ideally, is therapists to be cross-trained with MDMA, ketamine, psilocybin, ibogaine, 5-MeO-DMT, ayahuasca, whatever. And then the psychedelic clinics of the future will not be: ‘Here’s a ketamine clinic, here’s [an] MDMA clinic, here’s a psilocybin clinic.’ It will be psychedelic clinics, and the therapists will be cross-trained and they’ll customize a treatment program for each individual patient with any number of different kinds of psychedelics at different times in a sequence.” 

Links

Maps.org

Mapspublicbenefit.com

Thecut.com: You Won’t Feel High After Watching This Video

New York Magazine: Cover Story, Season One: Power Trip

Maps.org: Statement: Public Announcement of Ethical Violation by Former MAPS-Sponsored Investigators

Maps.org/safety

Psychedelics Today: Addressing Abuse in Psychedelic Spaces

Fromresearchtoreality.com: Global Summit on Psychedelic-Assisted Therapies and Medicine 

Psychedelics Today: Peter Hendricks Ph.D. – Is Psilocybin Helpful For People Who Abuse Cocaine?

Psychedelics Today: PT227 – Dr. Anne Wagner – Couples Therapy, MDMA, and MAPS

Psychedelicscience.org: June 17-25, 2023 in Denver

Psychedelics Today: PT236 – Dr. Carl Hart – Drugs: Honesty, Responsibility, and Logic

Forastateofhappiness.com: How is Gross National Happiness measured in Bhutan?

Psychedelics Today: Dr. Ben Sessa – Preliminary Results from MDMA Assisted Therapy for Alcohol Use Disorder

About Rick Doblin, Ph.D.

Rick Doblin, Ph.D., is the founder and executive director of the Multidisciplinary Association for Psychedelic Studies (MAPS). He received his doctorate in Public Policy from Harvard’s Kennedy School of Government, where he wrote his dissertation on the regulation of the medical uses of psychedelics and marijuana and his Master’s thesis on a survey of oncologists about smoked marijuana vs. the oral THC pill in nausea control for cancer patients. His undergraduate thesis at New College of Florida was a 25-year follow-up to the classic Good Friday Experiment, which evaluated the potential of psychedelic drugs to catalyze religious experiences. He also conducted a 34-year follow-up study to Timothy Leary’s Concord Prison Experiment. Rick studied with Dr. Stanislav Grof and was among the first to be certified as a Holotropic Breathwork practitioner. His professional goal is to help develop legal contexts for the beneficial uses of psychedelics and marijuana, primarily as prescription medicines but also for personal growth for otherwise healthy people, and eventually to become a legally licensed psychedelic therapist. He founded MAPS in 1986, and currently resides in Boston with his wife, with three children who have all left the nest.

Socials: Twitter / Instagram 
MAPS socials: Twitter / Instagram

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PT326 – Dr. Rick Barnett, Psy.D – Addiction, Recovery, and Competency in Psychedelic Therapy

In this episode, David interviews Clinical Psychologist and Founder of the Psychedelic Society of Vermont, Dr. Rick Barnett, PsyD. 

Barnett discusses the importance of building community in psychedelic spaces; psychedelic experiences as preventative medicine, and the differences between (and value within) the sanitized medical model and more ritualistic experiences. He talks about his own personal journey with addiction and recovery and looks at the interrelation between trauma, addiction, trust, and how psychedelics operate as disruptors – with a sense of meaning and purpose.

He discusses many of the current clinical trials happening around psychedelics and addiction; Alcoholics Anonymous and LSD; Vermont’s developing decriminalization bill (Measure H.644); the psychiatric workforce shortage and the potential solution of more prescribing psychologists; and, considering Oregon’s budding psilocybin therapy model, points out that one doesn’t need to be a licensed clinical practitioner with specific schooling to be a good psychedelic facilitator. Could we instead build models that are based largely on competency?

The Psychedelic Society of Vermont is putting on the Psychedelic Science & Spirituality Summit on the summer solstice (June 20-21) in Stowe, VT, with the goal of holding space for both the scientific and spiritual side of psychedelia. The conference is specifically for healthcare professionals, but all others are welcome to virtually attend or come to the summer solstice celebration after the conference. For more info, head to vermontpsychedelic.org.

Notable Quotes

“I had several profound experiences with LSD when I was a kid, and when I crashed and burned on alcohol and wound up in a 12-step rehab (the Hazelden Foundation), I quickly recognized that my experiences with LSD made me extremely receptive to the message that was being put forth to me in a 12-step-oriented rehab program. Concepts like surrender and a connection to spirituality, a connection to open-mindedness, willingness, being honest with oneself, taking one’s inventory – these kinds of concepts that are so common in 12-step programs – they resonated so strongly with me because of my experiences with LSD.”

“We have the ability to instill a sense of trust with our patients, and they can begin to trust themselves, and to trust the therapist, and to review some of these old hurts and really get into it over the course of therapy in a way that’s very healing. So it can happen with therapy, and I don’t think one is necessarily a substitute for the other. I think [psychedelics and therapy] work very well together. Psychedelics are yet another tool, just like therapy is a tool, just like AA is a tool, just like Suboxone and Methadone are tools. They’re all tools, and it’s really important to respect and honor that each one brings something positive, potentially, for an individual.” 

“An AA program, a harm reduction program, a therapy program, a psychedelic program, [a] meditation retreat: All these things provide a nudge, and potentially a very transformative nudge in the direction of like, ‘Okay, and then what?’ What are you doing in your daily life? …That ‘assisted’ part is not just assisted by a therapist. It’s not just assisted by a drug. It’s not just assisted by a shaman or an integration coach. It’s assisted by everything.”

Links

DrRickBarnett.com

Psychedelic Science & Spirituality Summit

Righttotrypsilocybin.com

Psychedelics Today: PT307 – Kathryn L. Tucker, JD – The Right to Try Act and the Battle for Psilocybin Access

Openstates.org: An act relating to decriminalization of a personal use supply of a regulated drug

Psychedelics Today: PT236 – Dr. Carl Hart – Drugs: Honesty, Responsibility, and Logic

Hazelden.org: Hazelden Foundation

Mydecine.com: Mydecine Receives Conditional IRB Approval for Phase 2b Smoking Cessation Study

Pubmed: Long-term follow-up of psilocybin-facilitated smoking cessation

University of Exeter: Ketamine and psychological therapy helped severe alcoholics abstain for longer in trial

Psychedelics Today: Dr. Ben Sessa – Preliminary Results from MDMA Assisted Therapy for Alcohol Use Disorder

Lucid.news: Bill Wilson, LSD and the Secret Psychedelic History of Alcoholics Anonymous

His Linkedin post about trust and being let down

About Dr. Rick Barnett, Psy.D

Dr. Rick Barnett, Psy.D., is the Co-Founder of the Psychedelic Society of Vermont, the Legislative Chair and Past-President of the Vermont Psychological Association, the founder of the non-profit organization, CARTER, Inc., and is a clinical psychologist and addiction specialist in private practice in Stowe, VT. Dr. Barnett has worked as a Clinical Psychologist in nursing homes, hospitals, and outpatient programs, and has trained hundreds of health professionals through workshops on addiction and mental health issues over the past 20 years. He is in long-term recovery of alcohol and substance abuse and is an active advocate for addiction treatment and recovery resources. Dr. Barnett holds a Bachelor’s degree in psychology from Columbia University, a Doctorate and Master’s Degree in Clinical Psychology and a Master’s Degree in Clinical Psychopharmacology. He is a Licensed Alcohol and Drug Counselor and holds certificate in Problematic Sexual Behavior (PSB-S) and Gambling Disorder.

Socials: Twitter / Linkedin 

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PT323 – Dr. Reid Robison & Steve Thayer, Ph.D. – Ketamine-Assisted Psychotherapy, Therapist Burnout, and LSD for Anxiety

In this episode of the podcast, Kyle interviews psychiatrist, Dr. Reid Robison, and clinical psychologist, Steve Thayer, Ph.D. Together, they host the Psychedelic Therapy Frontiers podcast and work at Novamind; Robinson as the Chief Medical Officer, and Thayer as the Clinical Director of Education & Training.

They talk about their respective journeys from psychology into the field of psychedelic medicine, their current work with ketamine-assisted psychotherapy (KAP) at Novamind, and their combined efforts in educating and training future KAP therapists and clinicians – a need they feel is going to become increasingly urgent as ketamine becomes more mainstream. To meet the challenge of scaling accessibility of psychedelic therapies, Novamind recently combined forces with Numinus Wellness, creating a platform and standard of mental health care within psychedelic therapy.

Robison and Thayer discuss the different ketamine dosing modalities and purpose for each; the ketamine sessions Novamind provides for frontline healthcare workers (called ‘Frontline KAP’ or FKAP); how difficulties in emotion-processing are often at the heart of mental health struggles; and how ketamine can help loosen emotional binding, allowing greater access to them. They also discuss current clinical trials on LSD for anxiety and alcoholism; how ketamine can be used for therapist burnout; the challenge of long LSD sessions and therapist stamina; the benefits of group ketamine sessions; the concept of combining ketamine with other therapeutic modalities (or substances); and the power of stepping aside and allowing the inner healer to take over.

Notable Quotes

“Difficulties in emotion processing are often at the heart of many mental health struggles. And if we can support the clients in developing skills and confidence in moving towards their emotions, and leverage the power of the corrective experience, the healing power of caregivers, [and] supporting them with emotion coaching skills, then we’re wrapping the client in this really powerful therapeutic healing environment and leveraging ketamine as a catalyst.” -Reid

“People will tend toward self-actualization and transcendence if you give them the environment to do so. To be well is not something we have to teach people to do, it’s something that they can remember how to do. It’s in them. If we can help them peel away the negative programming and conditioning and trauma and all that stuff, they’ll find their way to health and healing.” -Steve

“To me, it makes complete sense to use something like LSD for anxiety because what we think perpetuates something like generalized anxiety is what Steve Hayes of ACT might call ‘experiential avoidance’; that we don’t want to feel these intense feelings of fear or embarrassment or rejection or whatever it is, so we worry chronically, we get addicted to worry itself, [and that] keeps us safe from having to do scary stuff. And the LSD experience is just (for a lot of people) going to crack that open and give you an opportunity to face your fears, so to speak. It’s like exposure therapy on psychedelic steroids.” -Steve

Links

ReidRobison.com

DrStephenThayer.com

Novamind.ca

Psychedelics Today: Numinus Wellness to Acquire Novamind: An Interview with Numinus Co-Founder and CEO, Payton Nyquvest

Psychedelic Therapy Frontiers podcast

Psychedelic Therapy Frontiers podcast: Kyle Buller from Psychedelics Today on NDEs, breathwork, & training psychedelic therapists

Foundations of KAP Training Course from Cedar Psychiatry

Cedarclinicalresearch.com

MAPS MDMA Therapy Training Program

Novamind.ca: Frontline KAP Group Sessions for Health Care Workers

Sustained Subjective Benefits of LSD for the Treatment of End-of-Life Anxiety: Clinical Study by Dr. Peter Gasser

Wholeness.com: Dr. Scott Shannon

Psychedelics Today: PT302 – Dr. Adele Lafrance – Vital Psychedelic Conversations

Psychedelics Today: PT300 – Dr. Richard C. Schwartz – Vital Psychedelic Conversations

Phil Wolfson, MD

About Dr. Reid Robison

Dr. Reid Robison is a board-certified psychiatrist and Chief Medical Officer at Novamind. He is adjunct faculty at the University of Utah, founder of the Polizzi Free Clinic, co-founder of Cedar Psychiatry, the medical director for the Center for Change, and was voted Best Psychiatrist in Utah in 2020. Over the past decade, Dr. Robison has led over 200 clinical trials in neuropsychiatry. Notably, he served as Coordinating Investigator for the Multidisciplinary Association for Psychedelic Studies (MAPS) MDMA-assisted psychotherapy study of eating disorders. As an early adopter and researcher of ketamine in psychiatry, Dr. Robison led a pivotal IV ketamine study for treatment-resistant depression by Janssen, leading to FDA approval of Spravato™. Dr. Robison is also the co-host of the Psychedelic Therapy Frontiers podcast. 

Instagram 

About Steve Thayer, Ph.D.

Dr. Steve Thayer is a clinical psychologist and Clinical Director of Education & Training at Novamind. As a USAF military veteran, Dr. Thayer maintains his commitment to serving the veteran and first responder community through his position as the Executive Director of Therapeutic Operations for the World Voice Project. At Novamind, Dr. Thayer conducts and provides training in ketamine-assisted psychotherapy. He serves as Lead Therapist on several clinical trial studies involving psychedelic medicine. Dr. Thayer is also the co-host of the Psychedelic Therapy Frontiers podcast.

Instagram 

 

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