Download In this episode, Joe interviews Dr. David Nichols, American Pharmacologist and Chemist. Dr. Nichols has made many contributions to the psychedelic space and is recognized as one of the foremost experts for his outstanding efforts in medicinal chemistry of hallucinogens.
3 Key Points:
Dr. David Nichols is the founder of The Heffter Research Institute, which promotes research of the highest scientific quality with the classic hallucinogens and psychedelics in order to contribute to a greater understanding of the mind leading to the improvement of the human condition, and to alleviate suffering.
Dr. Nichols has a strong opposition toward the DMT/pineal gland theory. The assumption is that DMT is released during birth and death, but Dr. Nichols presents opposing arguments as to why it isn’t true.
David doesn’t believe in the research of microdosing psychedelics. He believes there are many other diseases and disorders that research money could be put toward discovering drugs for than the potential for heightened creativity with microdosing.
He is the founding President of Heffter Research Institute
He was introduced to psychedelics before he went to graduate school
David’s work was never interrupted during the drug war because he wasn’t doing any clinical work
He proposed the study for MDMA testing on rats for a micro-dialysis of chemicals being released from the brain
David’s History of Substances
David attended a meeting at the Esalon Institute
He met Rick Doblin, a young kid at the time, who was enthusiastic about MDMA and Marijuana
Rick decided he wanted to develop MDMA as a drug, and asked David to make it with him
Then David met Rick Strassman, who asked him to make DMT
So he made the DMT and then DMT Spirit Molecule came out as a result
David made the first batch of psilocybin for John Hopkins
“The only way to use these substances, is to use the medical model.” – David
Microdosing
David doesn’t agree with microdosing, he thinks its all just a big hype
He says that there is a huge placebo effect with microdosing
He says there isn’t a lot of proven results and literature to make him believe in it
He thinks that there are far too many other things to research and create drugs to cure (like eating disorders for example) vs. just heightening creativity with microdosing
David edited Torsten Passie’s book, The Science of Microdosing Psychedelics
DMT
Rick Strassman’s DMT hypothesis is that upon birth and death, the Pineal gland produces DMT, which produces an outer-body experience
David says that the pineal gland is too small, it’s only 180mg
It produces 25 micrograms of melatonin in 24 hours, so there is no way for it to produce 25 milligrams of DMT, the amount needed for a DMT trip
Heffter Origins
Heffter Research Institute was David’s idea
Arthur Heffter was a scientist with a PhD in Pharmacology and Chemistry
He was one of the most well respected Scientists in Germany
He got samples of Peyote, and knew there were alkaloids in it, and he separated all the alkaloids, and took each alkaloid himself to find out that mescaline was the active component in Peyote
He was the expert who invented hair tests to find out if people were suffering from lead poisoning
Heffter Research Institute
The effects that they discovered from Psilocybin blew them away
They knew LSD had powerful effects, but they weren’t expecting to find the therapeutic benefits that they did with Psilocybin
Psilocybin has a great timeline too, LSD is really long lasting, and 5-MEO-DMT is super short and really powerful
Psilocybin is great for use in therapy because of the time it allows for integration
GMP Psilocybin Patent
Joe mentions the patent of GMP Psilocybin and asks if there are other ways to make psilocybin
David says that he believes there are other ways to make Psilocybin
The cost of psilocybin is trivial in comparison to the cost of therapy, David doesn’t think that the drug itself will have a monopoly
Dr. Nichols originally conceived of a privately funded Institute as the most effective mechanism for bringing research on psychedelic agents into the modern era of neuroscience. This vision led to the founding of the Heffter Research Institute in 1993. He is currently an Adjunct Professor at the University of North Carolina Chapel Hill, NC, where he continues his research. The focus of his graduate training, beginning in 1969, and of much of his research subsequent to receiving his doctorate in 1973 has been the investigation of the relationship between molecular structure and the action of psychedelic agents and other substances that modify behavioral states. His research has been continuously funded by government agencies for more three decades. He consults for the pharmaceutical industry and has served on numerous committees and government research review groups. Widely published in the scientific literature and internationally recognized for his research on centrally active drugs, he has studied all of the major classes of psychedelic agents, including LSD and other lysergic acid derivatives, psilocybin and the tryptamines, and phenethylamines related to mescaline. Among scientists, he is recognized as one of the foremost experts on the medicinal chemistry of hallucinogens. His high standards and more than four decades of research experience set the tone to ensure that rigorous methods and quality science are pursued by the Institute.
In this episode, Kyle sits down with Dr. Torsten Passie, Professor of Psychiatry and Psychotherapy with the Hanover Medical School in Germany. In the show, they cover a range of topics on Dr. Passie’s studies on microdosing.
Dr. Torsten Passie will be taking part in a special panel dedicated to microdosing at Breaking Convention 2019 (August 16-18, Greenwich, London), also featuring Amanda Fielding of the Beckley Foundation, Dr David Erritzoe of Imperial College, London, Dr Devin Turhune (Goldsmiths), and Dimitris Liokaftos, exploring myriad aspects of microdosing, including its effects, unknowns, and media representation presented by BC director Nikki Wyrd. Find out more about Breaking Convention: https://www.breakingconvention.co.uk/
3 Key Points:
Psychedelic research in the University setting died off after 2004, but is finally seeing an increase as the psychedelic revolution continues to grow.
There is very little to no documentation of doctors doing self-experimenting with psychedelic drugs. It’s becoming popular for therapists to use the substances used on their patients, more common to do the self-work before doing the work on others.
Even if microdosing does not produce any significant effects and it is all placebo, the trend is a new way to introduce it into our society.
Dr. Passie has been researching psychedelics for 25 years
He specializes in the therapeutic use of psychedelic drugs
He has found difficulties in researching psychedelics during prohibition
Dr. Passie had a mystical experience before using psychedelics and then became interested in psychedelic use
He had grown up as an atheist, a materialist, and his experience required him to change his psychological state
His perception of reality was irritated and he had to see a therapist to integrate this experience
He said that this was frustrating because he was young and still in search for his identity
Through all of this, he decided to study medicine and become a psychedelic doctor
He became very conscious that he was on the right track
Research Studies
The researchers were the only ones doing studies on psychedelic states, there wasn’t much happening at the Universities
He did studies with cannabis, ketamine and even laughing gas
The research then was on how cannabinoids can help with psychosis
They were not successful with that, but it came to be that CBD was a neuroleptic and an anti-psychotic
Research pretty much stopped after 2004 due to new laws and the cost of the research
Dr. Passie does mention that in the past 10 years research has really taken off again and that we are really seeing the renaissance of psychedelic culture
In most of the literature of doctors doing self-experimenting, there is very little to no documentation of doctors doing self-experimenting with psychedelic drugs
Kyle mentions that MAPS has included into their training protocol to allow for therapists to have self-experiments with the substances that they are using on patients
Kyle also mentions he can’t imagine trying to hold space in breathwork without having had his own experiences with breathwork
Dr. Passie says that the history of self-experimentation with psychedelics has shown that the participants can become ‘gurus’ and lose their objectivity, he uses Timothy Leary as an example
But with only a few times of self-experimentation, maybe 2-4 times, he doesn’t see risks
HPPD
Hallucinogen persisting perception disorder (HPPD) is a disorder in which a person has flashbacks of visual hallucinations or distortions experienced during a previous hallucinogenic drug experience
Dr. Passie thinks there is a selection bias in what is published about HPPD
Its more common to have a study published that talks about an adverse effect of LSD than a benefit of it
Hundreds of thousands of studies were conducted in the 50’s, and no one claimed that this phenomenon came up
And now one person has conducted a study, claiming that this phenomena exists
Dr. Passie says that this pattern happens among people who are prone to anxiety and who are dissociative
He says that most subjects that claim to experience HPPD, have experienced visuals even before ever taking LSD
Microdosing
It has been known to not have any effects from 15-20 micrograms of LSD
20-50 micrograms of LSD is considered mini-dosing, where you can feel some type of effects from it, but not as much as the full dose
Dr. Passie says it is strange for people to claim to have increased cognition during microdosing based on conventional data that shows that LSD produces poor cognitive function
He thinks that whatever the effects are of LSD at a high dose, that the effects at a low dose are the same, just less, not completely different effects
He believes that there is some placebo effect with microdosing
In terms of the microdosing trend, Dr. Passie is critical about the productivity factor, he does believe in the creativity factor though
The flow state may also be increased with microdosing
He claims that in his own experience with microdosing, he doesn’t experience the flow state, in fact he experiences a feeling of agitation
Combinations
In a study, when patients took a microdose first, and then a little while later, they took a different full psychedelic dose, the microdose impacted the experience of the full dose
It lessened the effects of the full dose psychedelic
Psychedelics and Sleep
Dr. Passie mentions a study where patients were given LSD, both high and low doses, during sleep
What was found was that LSD impacts REM sleep patterns
The dreams were not altered
The REM phases got longer during the beginning of sleep, and then much shorter near the end of sleep
It shows that the impact of sleeping patterns brings someone to feel much different the next day
The Microdosing Trend
Microdosing has much to be explored yet
But even if microdosing does not produce effects, the trend is a new way to introduce it into our society
“Microdosing might be a new assimilation process of psychedelics into our culture” – Torsten
Instead of the 60’s where we are taking huge doses, we are taking tiny doses as a slow approach to assimilate psychedelics back into society
Torsten is a professor of psychiatry and psychotherapy affiliated with Hannover Medical School, and led the Laboratory for Consciousness and Neurocognition. He has conducted clinical research on psychoactive substances and has written several books including The Pharmacology of LSD (2010) and Healing with Entactogens (2012). Between 2012 and 2015 he was visiting professor at Harvard Medical School.
Download In this episode, Kyle interviews David Krantz, Certified Epigenetic Coach, and an expert in nutritional genomics. In the show, they talk about the effects of substances via the implications on an individual’s genetics.
3 Key Points:
Epigenetic testing is a bio-hack for boosting cognitive function and harnessing our creativity and ultimate human potential.
There has been a lot of research done on genetics and the effects of THC. The body produces cannabinoids that activate the THC receptors internally, which varies from person to person.
Each person should be seen on an individual level, and the more we know about our unique genetics, the more we can understand about our interactions with different substances.
David works with clients on creating optimal epigenetic expression
He uses people’s genetics as a guide to look at recommendations for diet, herbs, supplements, etc.
He began looking at cannabis for recommendations and found curiosity in psychedelics too
Epigenetics studies the effects of the modification of genetics
It looks at chemical groups attached to the DNA itself and what happens to them over time
Cannabis and Genetics
The most robust area of research on genetics is THC
David said he has seen some research on Psilocybin and just very recently that liver enzymes are responsible for LSD interactions
It looks at the way people are metabolizing these substances
When you ingest something or smoke it, it has a higher impact on the body, edibles are a great example
Kyle brings up the curiosity of edibles impact being either physiological or biological
Genetics show the body’s cannabinoid levels
The body produces cannabinoids that activate the THC receptors internally
There are two enzymes that break down cannabinoids in the body, Anandamide and 2AG
There is a higher likelihood to use cannabis in a person with lower levels of endocannabinoids
This makes some people high-functioning stoners, and others non-functioning stoners
The substance is neutral, it’s all about the body and how it reacts to it
When the liver breaks down an edible, it makes THC more potent
There is speculation that the slow metabolizers have a better chance of passing a drug test because they don’t have a chance to convert 110HTHC to the COOHTHC
Food and Substance Effects
Kyle mentions someone who was drinking grapefruit juice everyday for 3 weeks, and it potentiated the effects of Ketamine
In order to psilocybin to be converted to psilocin, you need a chemical in your body called alkaline phosphatase
Vitamin C deficiency and Vitamin B-6 deficiency all both correlated with alkaline phosphatase deficiency
David brings up his experience going keto, it worked really great for him, his energy levels increased, he lost weight, but his wife had a horrible time with keto
Then he looked to genetics and it made perfect sense to him as to why it worked for him and why it failed for her
Metabolism, biochemistry, genetics, and so many other factors impact a person’s reaction to substances
David also mentions that with companies like 23 and me, they get their money from selling people’s genetic information
He says Apeiron is focused on what you can actually do with the information, not just simply providing the results
David says its super valuable for people to know these things about themselves, how to mitigate stress, how the metabolism works, knowing what to eat, knowing vitamin deficiencies, etc.
Psychedelics in the Future of Epigenetics
David thinks were going to see that the epigenetics of psychedelics are going to show the ability to overcome trauma
When we look at people at an individual level, we all have our own idiosyncrasies and variations
“Because there is no such thing as an average human, let’s stop treating people like average humans and start treating them like they are individual people. Let’s stop leaving out the outliers.” – David
Taking an individualized approach to the psychedelic space is highly beneficial
David Krantz is a certified Epigenetic Coach who specializes in boosting cognitive function and helping clients harness their creative and personal power. As a lifelong musician, David sees the various systems of the body as parts of a complex symphony. And, as a coach, he excels at fine-tuning those parts to create resonant harmonious health. David also serves as Director of Psychoacoustics at Apeiron Center in Asheville, NC where he develops sound-based tools for better mood, energy, and focus. Additionally, he’s an expert in the pharmacogenetics of the endocannabinoid system and has developed a proprietary genetic test for looking at individual response to cannabinoids. A biohacker by training and artist by nature, David enjoys working with others who have a deep passion for enjoying life.
In this episode, Joe and Kyle sit down and chat with Veronica Hernandez and Larry Norris of Decriminalize Nature Oakland. Decriminalize Nature is an educational campaign to inform Oakland residents about the value of entheogenic plants and fungi and propose a resolution to decriminalize our relationship to nature, which just recently had success in doing so.
3 Key Points:
Decriminalize Nature Oakland is a campaign that just recently found success in decriminalizing psilocybin mushrooms as well as other psychedelic compounds naturally derived from plants or fungi, such as ayahuasca, peyote and DMT.
The mission behind Decriminalize Nature is to improve human health and well-being by decriminalizing and expanding access to entheogenic plants and fungi through political and community organizing, education and advocacy.
These decriminalization initiatives are gaining traction across many cities in the US. It’s about connecting to key people in the community and educating them, so they can use their reach to get information about these plants out there, to provide access to people everywhere.
Veronica is a clinical psychologist licensed in Peru
She has been working in the US as a Social Worker Clinician
She has been combining plant medicines and spirituality back into psychology
She is currently finishing her PhD at CIIS
About Larry
He is in the same PhD program as Veronica
Him and Veronica are the team that created ERIE
In between they have taken the time to run Decriminalize Nature Oakland
Decriminalize Nature
In this initiative, they had to convince 8 people of city council to agree to this, in comparison to the Denver Initiative, where they needed thousands of ballot signatures
This bill included naturally occurring psychedelic compounds, not just mushrooms
Larry mentions they used the word entheogen instead of psychedelic, as a way to create new conversation around the plant medicines a reduce the stigma
A Win for Plant Medicine
From where Veronica comes from, Ayahuasca and other plant medicines are national patrimony, state and church can’t touch them
To be able to bring these to a place where it’s considered schedule 1, Veronica is super inspired about being able to make this happen
Right now these plants are in a tug of war between money interest of the tax side and the government, and the other side of corporate interest
The goal now is to educate people on what these plants do, safe practices and develop places and services to hold the space and make these plants available to people
It’s about connecting to key people in the community and educating them, so they can use their reach to get information about these plants out there
Starting city by city is typically easier to initiate, to then have a better hold on direct action and education afterward to be able to duplicate on the state level
They have had 50 different cities from 30 different states reach out to make this happen in their communities
Veronica says that her first time trying San Pedro, she had felt an immediate connection to the plants
It became her goal to combine conventional medicine with plant medicines and make it available to everyone
“To be in touch with something bigger than yourself is one of the most important things” – Veronica
Sustainability
Although there was no verbiage in the bill, they are being mindful about sustainability of the plants when making them more available with decriminalization
Synthesis is a better idea for ibogaine, 5-MEO-DMT and other compounds that are naturally derived but also pose a risk to their sustainability with decriminalization
The landscape just doesn’t allow for synthesis right now, so we start at decriminalization and then hopefully open doors to the route of synthesis to aid in the sustainability of these substances and resources
Larry’s advice is that instead of spending your money and taking a trip to Denver or Oakland, to stay home and organize this is your own community because it can actually happen
It starts now and it starts with education
Joe says the most major push-back received in Denver for the decriminalization was the threat of people driving on mushrooms
Veronica Hernandez, is a clinical psychologist and shamanic practitioner from Peru. Since 2006 she has been trained on shamanic facilitation. She received her clinical training at the Institute of Rational-Emotive Therapy, New York, under the supervision of Dr. Albert Ellis. She was assistant professor at the Universidad Peruana Cayetano Heredia and research assistant at the Hospital Psiquiátrico Noguchi de Lima (Peru). In the United States, she worked as a Social Services Clinician at John Muir Health Hospital’s Inpatient Psychiatric Adolescent Unit, California. Currently she is completing her doctoral degree at California Institute of Integral Studies (CIIS), San Francisco, where she is carrying out research on the healing and transformative benefits of entheogens, especially Ayahuasca.
About Larry
Larry Norris, MA, PhD Candidate is the co-founder and executive director of ERIE (Entheogenic Research, Integration, and Education) 501(c)(3), a group dedicated to the development of entheogenic research and integration models. Larry is also a co-founder and on the Board of Decriminalize Nature Oakland and helped to co-author the resolution which received an unanimous decision from Oakland City Council. Beginning his studies in cognitive science as an undergrad at the University of Michigan, he is now a PhD candidate in the East-West Psychology department at the California Institute of Integral Studies (CIIS) in San Francisco. His dissertation reviews archived ayahuasca experiences to identify transformational archetypes that induce insights hidden within the experiences. As adjunct faculty at CIIS, Larry taught a graduate course called Entheogenic Education: Contemporary Perspectives on Ancient Plant Wisdom in order to discuss the concept of entheogens as educational teachers and cognitive tools. He was also an adjunct faculty at John F. Kennedy University teaching a class titled Paradigms of Consciousness. A dedicated activist and proponent of cognitive liberty, Larry’s efforts are a contribution to not only change the Western legal status of these powerful plants, fungus, and compounds, but also to emphasize the potential sacred nature of entheogens given the right set and setting.
In this episode, Kyle talks with Tom Lane, author of Sacred Mushroom Rituals: The Search for the Blood of Quetzalcoatl. In the episode, they discuss the history of Quetzalcoatl, the ceremony of the deified heart and sacred mushroom rituals.
3 Key Points:
Quetzalcoatl is a feathered-serpent deity of ancient Mesoamerican culture that can come to you when partaking in the ceremony of the deified heart. Quetzalcoatl teaches how to overcome fear and hatred and bring love.
The ceremony of the deified heart is a sacred mushroom ritual that when methods are combined correctly, can bring about Quetzalcoatl.
In the episode, Tom tells intriguing stories of his experiences with mushroom rituals and experiencing Quetzalcoatl, including a ceremony with Maria Sabina.
He was not an Aztec, he originated as a King in the Toltec civilization thousands of years before the Aztecs
As legend has it, where his blood fell is where the sacred mushrooms grew
Some people believe he was a Naga, a combination flow of energy, a male/female serpent
A winged, jeweled, male/female, serpent
In the ceremony of the deified heart, the serpent will come to you
About Tom
He was building geodesic domes in a remote area in Mexico
He had some of his first mushroom experiences, and it led him to realize that the story of mushrooms was about Quetzalcoatl
His first experience with the mushroom was mild
He said the mushrooms found him, he takes them as a sacrament
Ceremony of the Deified Heart
The legend was that Quetzalcoatl gave cacao to participants as an aphrodisiac and it would help release serotonin
The goal is not to talk a lot
Then, the mushrooms are to be retrieved from the ground, fresh
Before the ceremony, Tom says he likes to put four candles placed in all four directions
The key to eating the mushrooms is eating them totally covered with honey
You eat them two at a time, as it represents the male and female
And when you eat the mushrooms, you actually never swallow
You chew and chew and the mucous membranes of your tongue take the psilocin straight to the brain and spine
He says once it starts to take effect, it feels like there is a snake up your spine (He mentions his friends call this Kundalini)
Then you go out and Quetzalcoatl will come
When he comes, he is like a rainbow jeweled serpent, an embodiment of pure light, pure energy, pure love
Tom says the next day it feels like you’re 10 years younger
Its a pure force of love, an obliteration of the concept of time
Quetzalcoatl created this ceremony to bring about the serpent for healing, for a balance of male and female
This ceremony is best done during the night, with thunderstorms in the mountains
Ceremony with Maria Sabina
One night they went to see Maria Sabina
She agreed to do a ceremony at night
Her house was in the mountains and had a thatched roof with no windows or doors and sometimes clouds would come through her house
During a ceremony a lightning bolt came though the house, in one window and out the other
Maria’s daughter gave him truffle like mushrooms and he brought them back with him
Maria’s daughter really tried to learn his name, she repeated it a multitude of times until she said it exactly perfectly so she could say it during the ceremony
Quetzalcoatl Messages
God gave us love and pain
We have to learn how to celebrate the pain
God gave us knowledge, and tools of how to heal the pain
Tom’s goal is to teach people how to take the sacred mushrooms to meet Quetzalcoatl and find healing, love and peace
“Once you get rid of the ego, you get rid of fear, and then you have love.” – Tom
The only way you can overcome hatred and fear is with love
The body is teaching the mind when consuming the sacred mushroom
It’s best to just try to love people and be kind, and it’s all acts of kindness and love that makes a person feel good
Tom, Author, has a Bachelors in Forestry from the University of Tennessee and a Masters from the University of Florida in Science Education and Middle School Education. He has worked full time in the Solar Energy field as a Contractor and Trainer and has a background in Mushrooms. Tom spent some time in 1973 living in the jungles of Palenque in Mexico and learn about mushrooms and mushroom ceremony. Tom is the Author of the book, Sacred Mushroom Rituals, The Search for the Blood of Quetzalcoatl.
In this episode, Joe interviews Raquel Bennett, Psy.D. at Kriya Institute. In the show, they cover topics surrounding the properties and paradigms of therapeutic Ketamine use.
3 Key Points:
The Kriya Institute is devoted to understanding the therapeutic properties of Ketamine. Raquel Bennett specializes in using Ketamine therapy for patients with severe treatment resistant disorders.
There are three questions that should be used when determining if someone is fit for Ketamine therapy. Is it safe? Is it legal? Is it ethical?
There are many different paradigms for Ketamine Therapy, but determining the best method for each individual patient is the goal.
The Kriya Institute deals with how to work with Ketamine specifically in Psychiatry and Psychotherapy
Kriya provides clinical services to patients, training for other clinicians, and Kriya conference
The conference is a big collaborative meeting
Raquel is trying to create a patient assistance fund to make services more available to people
Ketamine
Ketamine isn’t addictive physically
It is possible to become psychologically addicted to Ketamine
Raquel thinks its a property of the person not of the object
It’s possible to become addicted to anything, shopping, sex, etc.
About Raquel
She first encountered Ketamine in 2002 when she was suffering from severe depression
She was seeing a therapist that took her to a psychedelic shaman where she took Ketamine
From the way she felt after taking Ketamine, she wanted to know if it was replicable for other people
She is interested in people with treatment resistant mood disorders, such as severe depression, unusual bipolar disorder and people living with active suicidal ideation
She remembers her teachers (who gave her Ketamine) saying they don’t use it often, and don’t know if it will work
They were not seeking an antidepressant effect, they were helping her to connect to the cosmos and the universe, to find out why she was having such severe depression
The fact that it acted as a rapid-acting antidepressant was a surprise to them, and that’s what triggered her curiosity with it
“Most of what I know of being a Ketamine provider, I learned from being a patient” – Raquel
Ketamine and Patents
Johnson and Johnson just came out with a filtered Ketamine product that they patented
$850 for 84mg of filtered Ketamine
$1.59 for 100mg of generic Ketamine
They are only providing it as a nasal spray
Companies tried to make a new molecule, but they couldn’t
Instead, they modified it, and filtered it, and then patented it (Esketamine)
Ketamine Treatment Paradigms
There is a lot of disagreement on the route, the dose, the setting importance, etc
This was the reason she created the Kriya conference, to share ideas, to find the best possible methods
One way is to give it as a low dose infusion out of the anesthesiology model (0.5mg of Ketamine per kg of bodyweight in an infusion center)
They aim to get enough ketamine in the patient’s body without the psychedelic effects
They take the normal dose, divide it by 6, and space it out to avoid the psychedelic nature
The patient is being forced into a passive role, they aren’t being called to heal themselves, they are just showing up for the medicine
Raquel says that’s not all that there is to it, the medicine is only half of it
Another paradigm for using Ketamine is facilitated Ketamine Psychotherapy
In this way, the Ketamine is used as a lubricant for talk therapy
We are using Ketamine to help people to talk about material that is too painful or too shameful to get to otherwise” – Raquel
In this paradigm, the emphasis is on the therapy, not the Ketamine, the Ketamine is a lubricant and a tool
In this way, the patient and the therapist are both participating 50%, the patient is not passive
She says the psychedelic effects are to be avoided, or else the patient becomes too far out
The third paradigm would be to induce mystical experience on purpose
As a provider, it is believed that the visions are meaningful
Only about 1 in 6 patients are actually a good candidate for psychedelic dosing
The patient is willing to offer their body up as a vessel, and the messages they receive are from God
The provider’s role is to make sure the journey is safe, and then help the patients to help construct meaning from what they saw, create actionable steps on how to change their lives
Raquel says that all of these paradigms are helpful, different methods work for different patients
That’s her job as a Ketamine Specialist, to determine which method is best for patients
“This is where the direction of the field needs to go, being aware of the spectrum of the services available, and then matching the treatment to the patient. Individualized treatment.” – Raquel
Proper Use
Is it safe? Is it legal? Is it ethical?
Is it appropriate to give Ketamine Treatment to someone without a profound impairment or disorder?
The literature supports the use of Ketamine for the following psychiatric or psychological disorders; major severe refractory depression, bipolar depression, physical pain with depression, recurrent suicidality and obsessive compulsive disorder
Do the potential benefits verify the potential risks?
Raquel doesn’t believe that making this experience available to everyone is the right way, her goal is to demonstrate that Ketamine is safe and useful for refractory problems
Group Administration
They can work with 6 clients at a time
It includes carefully selected individuals that all fit into the group
This provides a much lower cost for patients
Ketamine Types
There are 3 Types of Ketamine
The molecules themselves are not flat, they are 3 dimensional and fold in space
Some molecules are ‘right handed’ and others are ‘left handed’
Right handed molecules are Arketamine and left handed are Esketamine
Generic Ketamine is an even amount of Arketamine and Esketamine molecules
What Johnson and Johnson did with Esketamine was patenting the filtration process of removing Arketamine from the Esketamine molecules
Kriya Institute Site
Kriya Conference in November
A list of providers working with therapeutic Ketamine
Dr. Bennett is a Post-Doctoral Fellow in Clinical Psychology (PSB 94022544), working under the supervision of Dr. Bravo. Dr. Bennett primarily works with people who are experiencing severe depression, who are on the bipolar spectrum, or who are contemplating suicide. She has been studying the therapeutic properties of ketamine since she first encountered it in 2002. In addition to her clinical work, Dr. Bennett’s practice has evolved to include consultation services for medical professionals who wish to add ketamine services to their offices. She also lectures frequently about therapeutic ketamine. Dr. Bennett is the Founder of KRIYA Institute and the Organizer of the KRIYA Conferences.
In this episode, Joe records with Sean McAllister, an attorney who helped advise Decriminalize Denver. During this special, extra episode, Sean helps us understand the language in the recent bill for Mushroom Decriminalization in Denver, CO.
3 Key Points:
Recently, Psilocybin Mushroom Decriminalization passed on the ballot in Denver, CO.
Psilocybin mushrooms have not been made legal, they have simply been decriminalized. This means that Denver has the lowest law enforcement priority around psilocybin and that no money can be used to criminalize this behavior.
Decriminalization of Psilocybin in Denver is a big step toward changing the stigma around psychedelics. But we need to be careful, decriminalization is just a tiny step in the right direction and we need to be respectful and responsible with this initiative.
On May 8th, the city of Denver, Colorado voted yes on I-301, which decriminalizes the possession and use of Psilocybin-containing mushrooms. The official results will be certified on May 16th. As of May 9th – the unofficial results are – yes (50.6%) and no (49.4%).
I-301 decriminalizes adult (21 years or older) possession and use of Psilocybin mushrooms – making these offenses the lowest priority for law enforcement. This initiative also prohibits law enforcement to spend money and resources enforcing arresting adults with possession of mushrooms.
Sean’s Role in the Mushroom Decriminalization in Denver, CO
Sean is an Attorney with McAllister Garfield Law Firm in Denver
He has done a lot with cannabis law since 2005
He heard about the Mushroom Decriminalization campaign and began working with them
His role started in January to help the team understand what it would look like if the bill passed and his role definitely continues going forward now that it has passed
What the Vote Means
“Decriminalize” means just that
Psilocybin mushrooms have not been made legal, they have simply been decriminalized
“You should never be arrested for putting something in your body that grows naturally in nature.” – Sean
This means that Denver has the lowest law enforcement priority around Psilocybin
It’s not legal, it’s not regulated
This bill means that a person cannot be imprisoned for possession and cultivation for personal possession amounts
The city is not supposed to spend any money to criminalize this behavior
You can grow them to eat them yourself, but you can’t grow them to sell them
This also doesn’t mean that groups can host events and ‘give out’ mushrooms as a gift in return for a donation, this is not good behavior for this initiative
This initiative is simply a first step at looking at mushrooms in a better light and reducing the stigma
For the benefit of this bill passing, we have to be careful about amounts, the smaller the amount of mushrooms the better
There isn’t an amount listed in the bill to distinguish between personal use and intent to sell
The city has to establish a review commission
What this commission is supposed to do is track the public safety impact, use, criminal justice impact, etc
We hope and guess that psilocybin will not impact any of these, just like how marijuana did not impact anything for the worse when it was decriminalized
Once the city sees the results, they won’t have so much stigma about it, and Denver will lead the way for the state and the rest of the nation for sensible drug policy
Political Pushback
The typical response was “we already legalized marijuana, let’s not jump to something else”
Sean thinks this gives Denver an amazing reputation, that it understands therapeutic ability and research and no tolerance for the drug war
“We need a system that addresses public safety concerns but maintains as much personal liberty as possible on these topics” – Sean
Other Initiatives
Sean is a part of Chacruna, based in San Francisco
Oakland is attempting to Decriminalize Nature, which by nature means all naturally occurring substances
They aren’t on a ballot, they are looking to convince city council to agree with it and accept it
California attempted to raise signatures to be on the ballot in the 2018 election but it failed to get on the ballot
Oregon is now collecting signatures to get on the ballot at the state level in 2020
Oregon’s model is for medicalization, Sean expresses concern for a purely medical model
Between big pharma and quiet equity firms, they want to monetize on psychedelics like they did with marijuana, and that’s what we risk with medicalization
Psychedelic Liberty Summit in 2020 in the Bay Area will be to talk about the rights and wrongs around psychedelic initiatives
Final Thoughts
Sean mentions a possible system that revolves around a licensing structure
Similar to how we get a drivers license; we practice, we take tests, etc.
For psychedelics, we would need to learn the effects, harm reduction techniques, take tests to verify our knowledge, etc and receive a license that allows us to use psychedelics freely
If we abuse psychedelics and use them improperly, then we would get our license taken away, suspended, etc.
Overall, after this initiative passing, we have to be careful we don’t ruin this victory with poor behavior
Let’s just do what we’re doing respectfully, responsibly, and to ourselves
Sean T. McAllister is one of the nation’s leading cannabis business attorneys, licensed to practice law in both Colorado and California. Sean’s legal work focuses on the complex interplay between corporate law and state cannabis regulatory structures and federal law. Sean is a recognized leader in the cannabis industry. In 2004, he founded Sensible Colorado, which worked on all of the ballot initiatives in Colorado that culminated in recreational cannabis legalization in 2012.
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms
The recent publication summarizing the effects of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on mental health-related variables authored by myself and my colleagues has received great attention both from the scientific community and the public, see full text here; https://link.springer.com/article/10.1007%2Fs00213-019-05236-w
Although my colleagues and I are very pleased that the publication has been so well received, it appears that the study findings are being misinterpreted and misrepresented on (social)media primarily in the general public as an advocacy for use of toad secretion.
Not only is this very disappointing, as the publication is in fact communicating the very opposite, but it is also of great concern to me as the misrepresentation of the study findings may contribute to further unnecessary consumption toad secretion from Bufo Alvarius.
I, therefore, feel it is not only necessary, but also of high importance to clarify that the recent publication is in no way an advocacy or toad secretion use, but rather the opposite.
In fact, the article is summarizing the effects of 5-MeO-DMT, which is the main compound in the toad secretion – as demonstrated by a lab-analysis. This finding makes a clear and strong argument that toad secretion is in no way superior to synthetic 5-MeO-DMT, putting a scientific nail in the coffin for the discontinuation of toad secretion use as a means of obtaining and consuming 5-MeO-DMT.
Furthermore, the article also points to the ethical and ecological implications that comes with toad secretion use. Basically, the increasing demand for the vapor produced by toad secretion will disturb the ecological equilibrium of the toads through the invasion of habitat, excessive milking, amphibian trafficking, and black-market dynamics. Harassment of the Bufo Alvarius toad, however, can be easily prevented by using synthetic 5-MeO-DMT instead of vapor from dried toad secretion containing 5-MeO-DMT. You can read a summary of this issue to greater length here: https://psychedelicstoday.com/2018/10/03/ethics-ecology-bufotoxins/ ).
Additionally, even though many people have benefitted from sessions whereby 5-MeO-DMT from toad secretion has been consumed, others have instead, based on anecdotal reports, had a rather unpleasant encounter with the facilitator and so too experience with 5-MeO-DMT from toad secretion. The reasons for the unpleasant encounter vary per person, but as our recent publication highlight it is clear that some of the recent allegations of malpractice against two facilitators in particular, namely Octavio Rettig and Gerry Sandoval addressed in an open letter (read full text here; https://5-meo-dmt-malpractice.org/), extends beyond these individuals. In our recent publication it was demonstrated that the set and setting vary quite a bit from location to location of these sessions, dose(s) are not standardized but determined by eye-measuring, and span between 30-120 mg of toad secretion (those who received 30 mg dose may have had 7.5-9 mg of 5-MeO-DMT, whereas those who received 120 mg dose may have inhaled up to 30-36 mg of 5-MeO-DMT). Additionally, none of the facilitators have the necessary expertise (clinical background) to properly hold a safe space where altered states of consciousness can be entered, nor to screen for contraindications in participants that are included in a session. This is not only concerning, but also dangerous as it puts people in an unnecessary risk for having an unpleasant, and even traumatic experience which can impact them as well as those around them negatively.
Finally, although the study suggests that inhalation of vapor from toad secretion containing mainly 5-MeO-DMT (with very low traces of bufotenine and DMT) is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms, these findings are in no way conclusive. This molecule still needs further extensive research to assess safety, and to control for various other variables that may account and/or add to the outcome effects such for example set and setting, social desirability bias, therapeutic relationship, and placebo response.
About the Author
Malin Vedøy Uthaug, MSc, originally from Bergen, moved to Prague, The Czech Republic, after graduating from high school in her hometown in 2012. After obtaining her dual bachelor’s degree in Psychology from the University of New York in Prague (UNYP) and Empire State College (ESC) in New York in June 2016, Malin continued with her studies at Maastricht University, The Netherlands. Here, she acquired her master’s degree in Psychology with a specialization in Health and Social Psychology in the fall of 2017. During her research internship, Malin conducted fieldwork investigating the sub-acute and long-term effects of Ayahuasca on affect and cognitive thinking style. This field study was under supervision of Dr. Johannes Ramaekers and Dr. Jordi Riba, and was the starting point of her career as a psychedelic researcher.
After finishing her master’s, Malin continued working as a PhD candidate at the department of Neuropsychology and Psychopharmacology (FPN) from fall 2017. Her current doctoral research centers around the continuous investigation of the effects of Ayahuasca in naturalistic settings, and pioneer work on the effects of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in humans.
Outside of her thesis work, besides being a co-founder of the Norwegian Association for Psychedelic Studies, and a member of the editorial board of the Journal of Psychedelic Studies, Malin is also investigating the effects of Mescaline and Holotropic Breathwork. Finally, she is interested in trauma(resolution) and works hard to aid in changing the current treatment modalities available in the west by demonstrating the superiority of Non-ordinary state Psychotherapy (NOSP) through extensive research, (academic) writing and public speaking.
In this episode, Joe talks with Shane LeMaster, Licensed Addiction Counselor and Certified Mental Performance Consultant. Shane is also involved in Psychotherapy as well as Sport and Performance Psychology and Psychedelic Integration Therapy. In this episode they cover a range of topics such as social work, Ketamine, sensory deprivation, psychedelic icons and the psychedelic culture.
3 Key Points:
Shane has a podcast of his own, and his goal with the podcast is to bring people’s personal experiences to light to learn from them, to master the potential of our minds.
Ketamine is a great gateway to opening up people’s minds to all of the other psychedelics. Its also a great place to start for therapy.
Every single facilitator or shaman has different techniques and styles and that’s okay
If we don’t have differences then we won’t have styles to choose from.
Joe and Shane met up recently at a Psychedelic Club meeting about harm reduction in Fort Collins
Shane just got accepted into the PhD program in social work at CSU
He had been pursuing a PhD program in psychology and it wasn’t working out for him so he decided to take the social work route
He works with many people and has developed a strong skill set on the micro level and he wants to start making impact on a macro level with helping people
Social Work
Shane thinks of social work as an integrative approach for every discipline that we find useful, to come to a holistic, greater understanding of an issue
Shane wants to use Ketamine as a ‘medium’ term goal, because it’s legal
But ketamine is not where he is going to stop, he finds there are benefits in many other substances
He would love to work with LSD and Psilocybin
He will continue to offer his services through his business Mind Ops
Shane’s Podcast – Conversations with the Mind
His goal with the podcast is to bring people’s personal experiences to light to learn from them
It’s important to create dialogue and invite people for conversation with differing opinions
The goal is to create a theory that implements both opinions
Ketamine
Ketamine is a great gateway to opening up people’s minds to all of the other psychedelics
Shane has had a lot of personal and recreational experiences on Ketamine and when he returns to it as a medicine, he is able to attain and sharpen skills for mindfulness
Joe brings up the idea that recreational ketamine could have the ability to bring up past trauma or may re-traumatize someone if not used therapeutically
Ketamine has a lot of risks, but being educated and using the substance correctly can be absolutely beneficial
Shane says we shouldn’t try to avoid trauma, we should accept it and use it for good and let it power us
“Sometimes we don’t even know what were suppressing. We need some assistance to show us what were avoiding in life and I think that psychedelics help with that a lot.” – Shane
Sensory Deprivation
Shane says he’s interested in John Lilly’s work from back in the day and his terminology of being able to meta-program your human brain
Joe says John Lilly was a big part of isolation chambers which led to float tanks
Psychedelic Icons
Joe mentions Robert Anton Wilson, he was good friends with Timothy Leary
“My interest is not in psychedelics themselves, but psychedelics as a means to access higher states of who we are, parts we have forgotten.” – Shane
Psychedelics are just one way to tap into ourselves and discover our ultimate potential
“We should all be questioning, everyday, changing our belief systems” – Shane
“Belief is the death of intelligence” – Robert Anton Wilson
Shane says a lot of people give Leary a bad rap, but Shane appreciates what he has done
Joe mentions ‘smile squared’ – Space, migration, intelligence and life extension
TFYQA – Think for yourself question authority
“Turn on, Tune in, Drop out” – Timothy Leary
Shane says that phrase sticks with him, it called to his rebel phase in youth to grow and do this work in his life
The Psychedelic Culture
Splitting – a rephrase of divide and conquer
Joe says the psychedelic world is very cut throat
“We should take care of each other a bit more in this space” – Joe
Shane says, we need to lift each other up versus look for ways to step over each other
Every single facilitator or shaman has different techniques and styles and that’s okay
If we don’t have differences then we don’t have styles to choose from
“We can’t become fundamentalists in our own practices, we need to value the differences culturally and from a world view. They are all valuable.” – Shane
Shane earned his Bachelor of Arts Degree in Psychology from the University of Colorado in Boulder, CO, completed extensive coursework towards a Master of Arts Degree in Sport & Performance Psychology at the University of Denver, and earned his Master of Arts Degree in Sport & Exercise Psychology from Argosy University.
Shane is nationally certified as a Sport Psychology Consultant and a licensed mental health clinician in the state of Colorado. Having worked in community non-profit mental health since 2008, Shane has gained experience working with the entire spectrum of mental disorders and with all populations and age groups. Shane plans on attending a Ph.D program in Counseling Psychology where his interest in Resiliency, Mental Toughness, and Mindfulness Training Program Development can be explored and further developed.
He is a life-long athlete having competed at various levels in more than a dozen different sports. Because of his passion for warrior cultures of past and present, Shane has been ardently developing his own “Warriorship,” training in various forms of Martial Arts for 25 years. Shane feels that the self-discipline, the philosophy of non-violence, the innumerable mental and physical benefits, and the enjoyment that he gains from the Martial Arts is what helped drive his passion in the field of Psychology.
His personal interest in Eastern Philosophy stems from his adoption of a Buddhist lifestyle and blends well with his training in Western Psychological Science. Clients describe Shane as an out-of-the-box clinician that is easy to get along with, knowledgeable on a variety of topics, credible with lived experience, and as having the ability to make therapy fun and interesting.
In this episode, Kyle hosts a conversation with Veronika Gold from the Polaris Insight Center, a center that offers Ketamine Assisted Psychotherapy. They compare and contrast Ketamine Psychotherapy methods and Ketamine Infusion.
3 Key Points:
The most studied way of using Ketamine has been infusion, mainly used for treatment resistant depression and PTSD. Veronika used lozenges and intramuscular Ketamine therapy working for Polaris.
When people are healed from depression, there is a lot of anxiety and activation that happens. Infusion clinics don’t offer the therapeutic help that comes with Ketamine Assisted Psychotherapy.
The dissociation that happens with Ketamine is a different dissociation that happens with trauma. With trauma, dissociation happens when the nervous system can’t handle the stress in someone’s life, with Ketamine, it allows people who feel dissociated from their trauma, to feel again.
She is involved in the clinical trials for the treatment of PTSD, sponsored by MAPS in San Francisco
Veronika is originally from Czech Republic
She studied at CIIS
She grew up in the Czech Republic in a communist time so she dealt with a lot of trauma
She met Stan Grof at 16 at a Transpersonal conference
She was fascinated with his work and Transpersonal Breathwork became a part of her healing
It lead her to study psychology and become a psychotherapist and study non-ordinary states
Ketamine Assisted Psychotherapy
Ketamine therapy has been studied from the late 60’s until today
The most studied way of using Ketamine has been infusion, mainly used for treatment resistant depression and PTSD
In Ketamine Assisted Psychotherapy, the therapy is as important as the medicine
There is a biochemical effect of Ketamine
When people are healed from depression, there is a lot of anxiety and activation that happens
Infusion clinics don’t offer the therapeutic help that comes with Ketamine Assisted Psychotherapy
Benefits of Ketamine Psychotherapy
The treatment method used at Polaris includes a comfortable room, eye shades, music tailored to the therapy, and an ongoing therapist
They use non-ordinary states of consciousness as a part of the transformation
They use lozenges and IM (Intramuscular)
Only 30% of the ketamine from the lozenges are effective
The lozenges allow for a slow onset of the medicine
With IM, a higher dose can be used because it’s less taxing on the body and more effective
The property of Ketamine is dissociation
Veronika says she prompts people to explain where they are, to share about what comes up for them
“Sometimes there are memories that come up that are connected to their struggle. Sometimes they do full trauma processing. There are times where they go inside and then come out.” – Veronika
Ketamine vs. Classic Psychedelics
They used Ketamine as a means to do the work legally
For the work that is being done underground, the therapists are putting themselves at risk for legality, and it does impact set and setting
But even if other substances were legal, Veronika thinks Ketamine will still be used for certain issues
A moderate to high dose can allow people to have a near death experience or ‘review of their life’
The dissociation that happens with Ketamine is a different dissociation that happens with trauma
With trauma, dissociation happens when the nervous system can’t handle the stress
Opposingly, with Ketamine, it allows people who feel dissociated, to feel again
Veronika mentions a study that says the higher the effects of dissociation from a Ketamine session, the higher the antidepressant effects are.
She has work in somatic studies and organic intelligence
Breathwork
Veronika’s experience with Breathwork helps her understand her patients
The bodily experience that happens in Breathwork also helps her understand the body movement/energetic blockages, etc that happen in Ketamine therapy
The last 30-90 minutes is where the integration starts
Sessions
They do mainly one-on-one session but have done a few pair therapy sessions
Veronika says its easier to do one-on-one because the sessions are short and there is a lot of internal work
The Future of Ketamine
Veronika is excited about people’s curiosity with Ketamine therapy and the effectivity of it
Ketamine is a new and emerging field and we are figuring out who it is useful for and who it is not
Veronika says that non-ordinary states are all beneficial for healing, and not having to use Ketamine (using Breathwork) is still beneficial
“A big part of the healing is having a positive experience and connecting with places that feel good, having positive visions. Its supportive for our nervous system and our ability to heal.” – Veronika
“When we allow the inner healing intelligence to come through, it will take us to where we need to go.” – Veronika
Patients don’t always need to just feel the dark stuff and the trauma, sometimes sitting with the good feelings and remembering what good feels like is a part of the healing too
Kyle and Veronika were both on separate episodes of the Consciousness Podcast with Stuart Preston
Veronika has expertise in the treatment of trauma. Her approach is integrative and informed by Somatic Therapies, contemplative practices, and mindfulness. She also has an interest in educating others about the healing and transformational potential of non-ordinary states of consciousness.
In this episode, Joe interviews Computational Neuro-Biologist, Dr. Andrew Gallimore, one of the world’s knowledgeable researchers on DMT. In the show they discuss DMT and the possibilities of being in an extended state of DMT, such as accessing higher dimensions and communicating with intelligent entities.
3 Key Points:
This reality that we are in is a lower dimensional slice of a higher dimensional structure. DMT is a technology or tool that allows us access to reach out to these higher dimensions.
Andrew has developed and written about the Intravenous Infusion Model, which allows a timed and steady release of DMT to induce an extended state DMT experience.
Extended state DMT hypothesizes that with enough time spent in the DMT space, the ‘map’ of the space would begin stabilize over time and you could develop a ‘life’ in the DMT space like we do in our waking life.
Since age 15, he was into psychedelic drugs and altered states of consciousness
He was at a friends house and was looking at a book called Alternative London and it had writings on different psychedelics but only a very short segment on DMT
His fascination grew from his yearning to learn more about DMT
His interest turned into academic work, learning chemistry and pharmacology and he is now into learning more about the brain itself
He is currently a Computational Neuro-Biologist
DMT
DMT is a compound found almost everywhere in nature, highly illegal, yet highly interesting
Interaction with entities are common
All frames of reference are gone
Andrew says that the first few times were very intense and he would come back with no way to comprehend or describe it
Then after a few more times he started to see the entities and have a more stable experience with more intent
Andrew describes a very vivid experience of a man in a dark robe where he asked him “show me what you’ve got” and he opened his mouth and Andrew woke up a if he had seen God himself. He describes it as a shattering experience
These beings in the DMT experience, aren’t just pointless beings in a dream, they are powerful and extremely intelligent
We don’t have any way to comprehend the levels of intelligence in this dimensional space, we only are ever able to experience intelligence with our human capacity for what intelligence is
There is a sense that these beings are intelligent because they have been around for billions and billions of years or potentially infinitely
Communicating with Intelligent Entities
He calls his book the ‘textbook of the future’
“We are imprisoned in some kind of work of art” – Terence McKenna
This reality is a construct or artifact of the alien intelligence or the ‘other’
“This reality that we are in is a lower dimensional slice of a higher dimensional structure. DMT is a technology or tool that allows us access to reach out to these higher dimensions” – Andrew
DMT is everywhere
“Nature is drenched in DMT, but it takes a high level of sophisticated intelligence to identify it, isolate it, and discover a means of using it as a tool” – Dennis McKenna
“In order to communicate with these beings, we need to bring the right tools to the table” – Andrew
Target Controlled Intravenous Infusion Model – using the same model for DMT as the anesthesia model
It uses administration of a short acting drug using a mathematical model to control the release
“We are not just passive receivers of information but we are actively constructing our world from moment to moment.” – Andrew
Continuity Hypothesis of Dreaming – it says that dreaming is continuous with our waking life, the brain constructs the world when you’re asleep in the same way that it does when you’re awake
Extended State DMT (DMTx)
Our brains are constantly updating its model of reality, so if you put someone through the DMT space for months at a time, that person’s model of reality would completely shift
This idea has been completely unexplored
The hypothesis is that an extended time in the DMT space would begin to make that space more stable over time, the goal being to live in the DMT space as you would in this reality of waking life
The measurement of DMT in the blood with Ayahuasca is 1/5th the level of DMT in the blood as a breakthrough DMT experience
Andrew hasn’t heard of anyone trying the Intravenous Infusion Model yet
There is this space that exists one quantum away, and it is accessible by everyone (technologically, not necessarily legally)
Dr. Andrew Gallimore is a computational neurobiologist, pharmacologist, chemist, and writer who has been interested in the neural basis of psychedelic drug action for many years and is the author of a number of articles and research papers on the powerful psychedelic drug, N,N-dimethyltryptamine (DMT), as well as the book Alien Information Theory: Psychedelic Drug Technologies and the Cosmic Game (April 2019). He recently collaborated with DMT pioneer Dr. Rick Strassman, author of DMT: The Spirit Molecule, to develop a pharmacokinetic model of DMT as the basis of a target-controlled intravenous infusion protocol for extended journeys in DMT space. His current interests focus on DMT as a tool for gating access to extradimensional realities and how this can be understood in terms of the neuroscience of information. He currently lives and works in Japan.
Ibogaine is a psychedelic chemical found in the West African shrub Iboga. Bizarre in chemical structure and psychoactive properties, the drug remains mysterious to scientists and psychonauts alike. At high doses, ibogaine causes intense, unforgivingly introspective and dream-like hallucinatory experiences that can last upwards of 24 hours2. The African psychedelic might have remained nothing more than a curiosity in the West if not for the discovery of its ability to disrupt physical and psychological drug addiction4, 5. Thousands of anecdotal reports and preliminary scientific research provide evidence that a single dose of ibogaine can eliminate both withdrawal symptoms and craving in drug addicts1-7. In the United States, ibogaine remains a schedule 1 drug, and those seeking treatment must pilgrimage to countries that do not regulate it or take a chance with illegal underground treatment centers. What will it take for ibogaine to become medically available in the United States?
New drugs must undergo a rigorous vetting process to move from discovery to the legal market. To become a prescriptible medication, drugs must pass through clinical trials regulated by the Food and Drug Administration (FDA). These trials consist of a pre-testing phase, four clinical phases, and regulatory checkpoints throughout. Advancing to the next phase is predicated on successful completion of the prior phase.
Before moving to clinical trials, researchers must collect extensive pre-clinical data and submit an Investigational New Drug (IND) application to the FDA. Pre-clinical studies use rodent models to determine how effective the drug is for its intended purpose and its safety.
Phase 1 is the first set of studies to determine the safety and efficacy of the drug in humans. If these studies are successful, researchers can proceed to Phase 2, which are well-controlled studies with larger populations. Phase 3 studies test safety and efficacy with different dosages of the drug in even larger populations comprised of various demographics. While the time it takes to move through all phases varies, this process can take many years. After successful Phase 3 trials, the FDA reviews the data and the researchers submit a New Drug Application (NDA). The FDA reviews the NDA and the drug’s labeling to ensure accurate and sufficient information is provided to the consumer and drug-provider. The drug production facility is also inspected by the FDA for health and quality assurance. If the drug is approved, it will be released on the market and available for prescription. Phase 4 trials occur only after the drug has been approved and is publicly available. In Phase 4, the drug manufacturer must continuously monitor the effects of the drug in patients and submit safety reports to the FDA.
For ibogaine to come to market, it must pass through each of these clinical phases of study. Remarkably, ibogaine began the process of becoming an FDA approved therapeutic medication in the early 1990’s. Pre-clinical and Phase 1 trials conducted by Dr. Deborah Mash at the University of Miami supported the anecdotal evidence that patients had significantly reduced drug withdrawal and craving following ibogaine administration. These trials ended prematurely as a result of several factors, including criticism from the pharmaceutical industry, the apparent costliness to continue, and an intellectual property lawsuit between Mash and ibogaine crusader Howard Lotsof1, 2. No clinical trials have been conducted with ibogaine since this preliminary work over 20 years ago.
Another issue facing the medical legalization of ibogaine is that it cannot simply be prescribed in pill form by a doctor. The drug must be administered in a therapeutic setting, potentially as an aid to psychotherapy, as is the case with MDMA. Pre- and post-counseling are vital to ensure proper translation and integration of the psychedelic experience, as well as addressing the underlying problems that contribute to drug abuse. Furthermore, patients must implement changes outside of the clinic to ensure successful treatment outcomes. This means getting away from the external factors that contribute to drug abuse, which can include leaving relationships with friends, family or partners, and/or moving to a new area. While legalization for medical application is important, there must also be infrastructure developed to support proper administration of the drug.
There have been cases of death associated with taking ibogaine. However, none of these cases have been a result of overdose or toxicity2. Individuals with certain heart conditions are at a higher risk of cardiovascular-related death after consuming ibogaine, and taking drugs of abuse with ibogaine may cause adverse reactions that can result in death. Rather than supporting the case against legalization, the risk of death for certain patients further evidences the necessity of legalization: unlike some clandestine ibogaine sources, regulated treatment centers would have the resources to screen patients for comorbidities (reasons not to ingest the drug) prior to ibogaine administration.
Ibogaine has many hurdles to overcome in order to reach the legal market, but pharmacologist Stanley Glick at Albany Medical College and chemist Martin Kuehne at the University of Vermont developed a drug that could reach consumers much faster: 18-Methoxycoronairidine (18-MC). 18-MC is a derivative of ibogaine intended to produce the same anti-addictive properties without the negative side-effects or psychoactive experience. Some ibogaine advocates contend that the psychoactive experience of ibogaine is equally important for attenuating addiction as the physiological effects. But 18-MC’s lack of psychoactivity will likely be more palatable to consumers, and to the FDA.
The process for making 18-MC medically available is already underway. In 2014, a company called Savant HWP began pre-clinical and Phase 1 trials with 18-MC funded by the National Institute on Drug Abuse. These trials were successful, and Phase 2 trials are set to begin this year. If clinical trials continue to be successful, 18-MC could be an FDA approved treatment for addiction within the next decade.
18-MC becoming available to patients would be a massive step towards ending the opioid crisis, but ibogaine remains full of unexplored potential. While the legal status of ibogaine in the US makes research a significant challenge, countries in which ibogaine is unregulated provide the opportunity to study its use in legal clinics. In 2017, the Multi-Disciplinary Association for Psychedelic Studies (MAPS) sponsored two studies investigating the efficacy of ibogaine in Mexico and New Zealand3, 7. With abundant data available for legal collection across multiple fields of study, scientists are just beginning to scratch the surface of ibogaine research. Those interested in studying ibogaine should not be discouraged by the barriers in the United States and should look abroad for more opportunities. For more information about how to get involved in ibogaine and other psychedelic research as a scientist, you can read our post here.
Not a scientist? You can still get involved! The simplest action you can take is to call and write your state and federal legislators. Explain how ibogaine’s legal status is hindering the scientific investigation and preventing sufferers of addiction from receiving effective treatment. During voting season, research how the candidates feel about illegal drugs and vote accordingly. You can also donate money to MAPS and other legitimate research organizations to support the scientists who are currently studying ibogaine.
If you are interested in learning more about ibogaine or 18-MC, you can visit the following links:
Alper, Stajić, & Gill, (2012). Fatalities Temporally Associated with the Ingestion of Ibogaine. Journal of Forensic Sciences, 57(2), 398-412.
Brown, & Alper, (2017). Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes, The American Journal of Drug and Alcohol Abuse
Cappendijk, & Dzoljic. (1993). Inhibitory effects of ibogaine on cocaine self-administration in rats. European Journal of Pharmacology, 241(2), 261-265.
Glick, Kuehne, Raucci, Wilson, Larson, Keller, & Carlson. (1994). Effects of iboga alkaloids on morphine and cocaine self-administration in rats: Relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Research, 657(1), 14-22.
Mash, Ameer, Prou, Howes, & Maillet, (2016). Oral noribogaine shows high brain uptake and anti-withdrawal effects not associated with place preference in rodents. Journal of Psychopharmacology, 30(7), 688-697.
Noller, Frampton, & Yazar-Klosinski, (2017). Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study, The American Journal of Drug and Alcohol Abuse
In this Bonus episode The Teafaerie and Joe Moore get into lots of great topics. Enjoy! !
The Teafaerie micro-bio(me)
The Teafaerie is a writer, flow arts teacher, ruespieler, toy inventor, app designer, street performer, party promoter, and superhero. erowid.org/columns/teafaerie
This interview was transcribed from our Navigating Psychedelics: Lessons on Self-Care & Integration master class with Elizabeth Gibson of Dreamshadow Transpersonal Breathwork. In this interview, Elizabeth shares her insights of integrating exceptional experiences from facilitating and working with Holotropic Breathwork for over 25 years. Elizabeth has a great wealth of knowledge about the integration process and we are honored to present her insights.
Introduction
Kyle Buller: Welcome to the Psychedelics Today exclusive interview for the Self Care and Integration course. Today we are here with Elizabeth Gibson of DreamShadow Transpersonal Breathwork to talk about integration and breathwork. Thank you for joining us today, Elizabeth. It’s great to have you on.
Elizabeth Gibson: Thanks for having me, I’m happy to be here.
Kyle: So, let’s dig in, what does integration mean to you?
Elizabeth: Well, it’s a big topic and a really important topic to me. To me, integration is one of the most important aspects of work with extraordinary experiences. How do you take material that’s come up for you and bring it into your everyday life? That’s where the real benefit of this work comes from. I think it’s a topic that’s often overlooked.
So, how do people go back out into the world and realize the benefits of the intense inner work that they’ve done? That’s what it’s about to me. It’s about how people figure out how to do that and supporting them in that process.
Kyle: To backtrack a little bit, you have been facilitating breathwork for almost 20 years at this point? [25 years as of 2019].
And then you also were part of some MDMA therapy back in the 80s, right? When it was legal? So, you’ve been in this work for a while — working with people with non-ordinary states and doing integration work.
Elizabeth: Trying to, yeah.
Joe: What are some of the most important thing you see people maybe not do adequately to try to integrate?
Elizabeth: Well, I think the basic principle that we always remind people of when they are leaving a workshop or leaving a session that has involved an intense experience of any kind is the ongoing nature of the process. So, a lot of people who are, especially people who are new to this work, tend to think it’s all about the session.
The session, of course, is extremely important, but the process continues after the session is over. The intense emotions or material that has begun to come up during the session, if it’s a very organic process, can continue in the days and weeks after the session has actually taken place.
So, it’s really important to remind people that it’s important to give themselves space and to allow that process to continue and to really respect what’s going on inside and not try to jump right back into everyday life and the demands of work. given that, for many people, that’s a very difficult thing. People have jobs and families and relationships that they’re going back to.
It is important to remind them to remember the ongoing nature of the process and that it’s not all about your hours in the session. I think all of us who have done this work ourselves personally, I mean, I remember after when I did MDMA-assisted psychotherapy back in the ’80s, I can remember for days afterwards just kind of yearning to get back in the space I had been in.
It seemed like such a sweet experience and my life outside of the session seemed pale by experiences. It’s almost if I was trying to get back to where I had been in the session instead of understanding that I needed to pay attention to what was happening to myself right now in the moment and reconnect with myself in that way.
I think that’s really what integration is about — learning to be more present and authentic with ourselves in the moment. No matter what we are doing, whether we’re in an intense session or you know, even something as mundane as washing the dishes.
Kyle: Yeah, you make some really great points. Joe and I put that quote, “chop wood, carry water” in our presentation in this course. But also, it seems like people want to jump back into sessions again, like I think we brought up the fact that people may want to just go back and do ayahuasca ceremonies over and over again.
Maybe not because of the purging aspect, but just continue taking drugs to stay in that state (of consciousness). Or go back and do a bunch of breathwork sessions to move through some stuff. I think it is important to have that downtime and really be able to embody the experience and really understand what that means.
Elizabeth: I agree, Kyle. I think a lot of the changes that come about as a result of doing this work are subtle changes. The traumatic changes are fairly obvious and maybe don’t need as much attention in the sense that with the subtle changes they can be easily overlooked. The long-term changes that take place over time, those are the ones that I think you really want to honor and respect and give space to allow that to happen in yourself.
Developing A Daily Practice
Kyle: Do you have any tips or advice to how to stay in the moment after a session for the next week or a couple months to really embody what just happened?
Elizabeth: Yeah, well that’s the challenge. I think that it really is a very individual thing. There are specific techniques that can be used. I was looking this morning, and Stan Grof spoke in his book, Holotropic Breathwork, He has a couple of entries for integration. He talks about specific kinds of techniques that can be helpful for people after they do this kind of work. And you know, it’s the kinds of techniques that allow you to tap into yourself, be it whatever kind of form meditation works for you.
Some people like sitting meditation, some people like more active kinds of meditation like tai chi. Some people can’t really connect with meditation at all and there can be other kinds of activities like I remembered when I read Stan’s passage that he used to recommend for people who had intense kinds of physical experiences, that aerobic exercise, like swimming, running, for people who might be inclined in that way, who are more physically active, just as a way of connecting with the kind of energy and feelings that are operating at the deeper levels.
So, for me, I always have found it helpful to journal about my experiences in the days afterward. Not right after an experience because I’m not that verbal yet, which is why initially after a breathwork session, for instance, we offer drawing materials so people can just work with shapes and colors and begin to work with their experiences symbolically on that level before even putting words to them.
But then maybe a day or two later, I always find it really helpful to write about my experience. I notice if I keep up the process journaling in the days moving forward from there, I’m apt to stay more connected with the feelings of the experience.
But again, it’s whatever works for an individual person to create space for themselves to just sink into themselves. Basically, that means some kind of ongoing form of practice, daily practice, whatever works. And that’s a very personal and individual kind of thing.
And we’ve all, I know, tried in our lives to stick to some kind of practice. We’ve tried lots of things. What I’ve learned over the years is for me, I have to make my practice manageable. I can’t try and make it too big. So, I’ve learned for me, if I do something every morning for about half an hour, that’s probably the most realistic expectation I can have for myself.
So, I like to do yoga and tai chi, and I like to journal. Some combination or at least one of those, ideally in the morning. But then during the day, I mean, think what you like to do to nurture and support yourself. Get outside, go for a walk, connect with nature, to work it into your daily life as much as you can so it’s not like a separate kind of thing that becomes one more thing to do every day that you may not get to.
Kyle: Right. And then if you start acting that way, then you start beating yourself up that you’re not practicing, so yeah. I know that happens to me. I’m like, “Ah, I should really meditate more.” Then I think to myself, “Well, why am I beating myself up over it?”
Elizabeth: Yeah, yeah.
But do you find that? I mean, I do. I know that if I do something first thing in the morning, then if I wait ’til the end of the day, it’s less likely that it’s going to happen, so-
Kyle: Absolutely.
Elizabeth: My tai chi teacher used to say, “Just do it before you think too much about it. Get up and do it.”
The Importance of Community and Group Process
Joe: Can you think of any things not to do that might impact integration in a negative way?
Elizabeth: That’s a really interesting question, Joe. Things not to do. I think it’s important not to isolate yourself after you do this kind of work. So, that in addition to the whole principle of the ongoing nature of the process, I think the principle of community is really important.
I’ve come to appreciate the community around breathwork over the years — the relationships that we have created and the support that people offer each other. I really think we can’t do this kind of work completely on our own. We need support not just during the sessions, but in the days and weeks, months and even years between sessions.
We need support. We need to be able to talk with people about our experiences. We need to process our experiences verbally. I mean, we’re very social animals as human beings and we thrive in group kinds of settings. Now, some people at first are put off by group experiences and prefer to work one on one, maybe with a guide or a therapist. And that’s fine, but usually, there’s at least one other person involved. Somebody who can help you get through the rough spots in a way that’s supportive and not overly directive. And that can be a good friend as much as a therapist or an experience facilitator.
Kyle: Yeah. What’s Lenny’s saying? “We’re the descendants of very successful tribes.”
Elizabeth: Yeah, we’re all the descendants of successful tribes. So, that’s part of our heritage. I think in our margin, in our modern culture, that’s something that’s missing. And you see a lot of people just yearning for that kind of communal experience.
A lot of people come to our workshops, I see them get so much meaning and joy out of just the personal connections that are made. A lot of people are simply lonely, and you just need that kind of contact and the building of community and relationships.
Kyle: It makes me think a lot about rites of passages, how those are formed, say, in some of those traditional cultures where maybe the adolescent would go out and you’d have this experience, but then they’d have the safety net of the elders, the container, and the community to come back to.
And when we have these really big experiences, I mean, we might have a few people to talk to, but we don’t really have that community to come back to. I know after my near-death experience, I was like, “Whoa, who do I talk to you about this now? I can’t really talk to my parents about it.” And I had to leave to find that. And I found it in Burlington. I found it in breathwork with you and Lenny.
Elizabeth: I remember that about you, Kyle. And that was a process that took many years for you to build that kind of community. So, as a young teenager, that was really … As I understand it, that was one of the hardest aspects of it afterwards was that you didn’t have anybody you felt you could really talk to.
Kyle: Yeah, exactly. And that’s been one of the biggest integration pieces for me when I think about integration — how do you just be okay with the people around you and learn how to just embody that experience even though you might not be able to talk to that person necessarily? How do you continue to be in a relationship with them and not feel so isolated?
Elizabeth: Well that kind of goes back to your last question, Joe, of what not to do. So, Kyle just touched on that really when he mentioned who you can’t talk to about these experiences. So, I think it’s important to search out people who you know will be supportive and understanding, and not share your experiences with people who might discount or trivialize your experience because they just don’t understand this kind of work.
And that can be lonely if it’s somebody important in your life that you can’t discuss these kinds of experiences with. That’s definitely a big dilemma.
Kyle: Do you have any tips or advice to work through anything that arises after a workshop or an experience? We talk about the process continuing, but maybe how to work with some of that stuff that comes up in the next coming weeks to months.
Elizabeth: Well, so if there’s somatic stuff coming up in the body, it can be really helpful to go get some bodywork after a session. A really good deep tissue massage or any kind of work that’s going to help resolve things that might still be coming up in the body. We’re fortunate now in this day and age, there are so many different kinds of bodywork.
Bodywork can be extremely helpful.
And then those of us who are holding the space for people and supporting this kind of work, I think it’s on us to make ourselves accessible to people after the sessions and to say that we can be available for them to reach out and contact us if they’re having trouble — so that they know there’s somebody who understands what they’ve been through who’s there for them to listen to them.
I mean sometimes people just need to talk. It’s not like you have to do much else than just listen and support them with your attention. People need to be heard and feel that what they’re experiencing isn’t totally abnormal but it’s just a normal part of their process. That can be all they need maybe. Just a friend or a person who understands that they can talk with.
Joe: That ties into a lot of what we’ve been talking about lately where, maybe you have these integration groups, but that’s the essence of it right there is just to talk and be heard.
Elizabeth: I love the idea of the integration groups that you guys are doing. I mean, I think that’s exactly the kind of format that will help fill in the space in between experiential sessions and give people the sense of community and belonging.
I mean look at the whole AA thing, the fact that that’s done as group work. I mean, people struggling with in the addiction field, they go to groups that meet regularly where they can talk about their experiences and share them and feel that kind of support.
That has been an incredibly successful approach over the years. So, I think your idea of having these integration groups is exactly the kind of approach that’s going to be helpful for people who are struggling with integrating extraordinary experiences. I’m really happy you’re doing that.
Kyle: Thank you. Yeah, part of it too is we come to your workshop for a weekend, have these really close connections, have these really powerful experiences, and then in between it’s like, “Oh, where’s that community?”
So, part of it for me is how do we keep it going? How do we keep the conversation going and finding those people that we can support and hold space for so the process can continue and it’s still healing with it.
Elizabeth: Technology has made that easier too. I mean, look at what we’re doing right now. And the fact, even as an email group, you can continue sharing. It definitely has its limitations, but it’s better than nothing.
Don’t Make Any Big Changes Right Away
Joe: You often speak about not making any big changes in the next six months. Can you speak about that?
Elizabeth: Yeah. Well, a lot of times people take material that comes up in their sessions, there’s a tendency maybe to take it literally and think that to interpret their session in a certain way that makes them think, “Oh, that means I need to leave my job right now, or I need to end this relationship now.”
We encourage people to sit with that for a little while before they act on it, to be sure that things have settled and that they’ve had some time to process their experience a little more before making any major life decisions.
But there are no hard and fast rules about that. It’s just something to be aware of. People can have amazing insights and extraordinary experiences that are … Can be taken literally. But sometimes as you know, there are many levels to these experiences, and you have to treat them symbolically or metaphorically. So, it’s just a caveat, but not a hard and fast rule.
Final Thoughts
Joe: Is there anything, any additional points you might want to raise before we kind of wrap up here?
Elizabeth: I would just encourage people to reach out when they feel like they’re having difficulty or trouble understanding something that might be going on, and knowing that there are all kinds of groups out there. And to be sure that when they do this kind of work, they do it in a safe setting, and that they have access to people who will be able to support them afterwards.
The MAPS website is a really good resource for understanding this aspect of the work. I think there’s material there about safety set and setting. So, to keep all of those considerations in mind, I would just end with that reminder.
Joe: You’re never alone and people do want to help you.
Elizabeth Gibson, thank you very much. You can find her website at dreamshadow.com.
Elizabeth: Thank you.
About Elizabeth Gibson
Elizabeth Gibson, M.S., holds a bachelor’s degree in literature and a master’s degree in biology from The University of Tulsa. She has completed Herbert Benson’s Clinical Training in Mind/Body Medicine at Harvard Medical School. Previously she worked as a consultant at Arthur D. Little, Inc., and Radian Corporation in the areas of environmental protection and food research. She is a writer, editor and homemaker with interests in environmental literacy, yoga, music and gardening. Elizabeth is the editor of Stanislav Grof ’s The Ultimate Journey: Consciousness and the Mystery of Death and a contributor to the teaching manual MDMA-Assisted Psychotherapy for the Treatment of Posttraumatic Stress Disorder, both published by the Multidisciplinary Association for Psychedelic Studies. For the past 12 years, she has been responsible for local news for the Town of Pawlet, and from 2008 – 2014 she was the editor of the weekly environment section for the Rutland Herald and Montpelier Times Argus newspapers in Vermont.
In this episode Kyle and Joe sit down and discuss Esketamine, a new FDA approved drug that is a derivative of Ketamine. They invite quotes from professionals who have experience with generic Ketamine and to voice their opinions.
3 Key Points:
Janssen Pharmaceutica has announced an FDA approved derivative of Ketamine, Esketamine, called Spravato.
The new drug is facing critique on its pricing, route of administration as well as functional differences when compared to the traditional, generic Ketamine.
Joe and Kyle invite professionals in the field who have experience with generic Ketamine to voice their opinions, hopes and concerns about Spravato.
Janssen Pharmaceutica, a Johnson & Johnson Subsidiary has created a derivative of Ketamine called Esketamine and has gone through the whole FDA approval process
There has been some concern about a big pharmaceutical company, Janssen coming in and creating a ‘new molecule’ and introducing an FDA approved ‘psychedelic’ to make generic Ketamine obsolete
Pricing
There is going to be price differences based on routes of administration (Intravenous vs lozenges)
$1.59 at 100 milligrams (93% bioavailable when administered IM)
The list price of Esketamine through Janssen will be $590-$885 per treatment session based on the dosage taken which will vary between patients
During the first month of therapy, that would add up to $4720-$6785
After the first month, maintenance therapy could range from $2300-$3500
Joe reads a quote from Scott that says that the new Janssen Esketamine product is overpriced, the research data showed that only 2 out of 5 studies demonstrated effectiveness, and generic Ketamine is much more effective and cheaper than Esketamine
Insurance
Insurance might cover Esketamine
Kyle says he hasn’t heard of too many generic Ketamine sessions being covered by Insurance
“I need not continue the discussion. The case is too clear for elaboration. Yet the trained body of physiologists under the influence of the ideas germane to their successful methodology entirely ignore the whole mass of adverse evidence. We have here a colossal example of anti-empirical dogmatism arising from a successful methodology. Evidence which lies outside the method simply does not count. We are, of course, reminded that the neglect of this evidence arises from the fact that it lies outside the scope of the methodology of the science. That method consists in tracing the persistence of the physical and chemical principles throughout physiological operations.” – quote from Function of Reason
Opinions
Joe invites listeners to ask questions and leave a message of opinions and such (either anonymously or using your name)
Google voice 970-368-3133
About Kyle
Kyle’s interest in exploring non-ordinary states of consciousness began when he was 16-years-old when he suffered a traumatic snowboarding accident. Waking up after having a near-death experience changed Kyle’s life. Since then, Kyle has earned his B.A. in Transpersonal Psychology, where he studied the healing potential of non-ordinary states of consciousness by exploring shamanism, plant medicine, Holotropic Breathwork, and the roots/benefits of psychedelic psychotherapy. Kyle has co-taught two college-level courses. One of the courses Kyle created as a capstone project, “Stanislav Grof’s Psychology of Extraordinary Experiences,” and the other one which he co-created, “The History of Psychedelics.”
Kyle is currently pursuing his M.S. in clinical mental health counseling with an emphasis in somatic psychology. Kyle’s clinical background in mental health consists of working with at-risk teenagers in crisis and with individuals experiencing an early-episode of psychosis. Kyle also facilitates Transpersonal Breathwork workshops.
About Joe
Joe studied philosophy in New Hampshire, where he earned his B.A.. After stumbling upon the work of Stanislav Grof during his undergraduate years, Joe began participating in Holotropic Breathwork workshops in Vermont in 2003. Joe helped facilitate Holotropic and Transpersonal Breathwork workshops while he spent his time in New England. He is now working in the software industry as well as hosting a few podcasts. Joe now coordinates Dreamshadow Transpersonal Breathwork workshops, in Breckenridge, Colorado.
In this episode Joe interviews, Richie Ogulnick, a long time Ibogaine provider and enthusiast. During the show they discuss Ibogaine and Addiction-Interruption Therapy.
3 Key Points:
Ibogaine is a compound found in the Tabernanthe Iboga plant that has been used to treat opioid and other addictions.
Ibogaine has shown to have the power to reset the biochemistry of a person to a non-addictive state, and reduce/eliminate the agonizing symptoms of withdrawal, allowing a person to heal from an addiction.
The combination of Ibogaine, relocation and integration therapy is the best scenario for healing someone and preventing them from relapse.
In 1989 he was Introduced to Ibogaine while visiting family and friends in New York
Its an alkaloid extracted from a West African shrub
He was ready to fall in love with doing something with purpose
He came across an article about a corporation called NDA created by Howard Lotsof
When Howard (a heroine addict) was 19 years old, a chemist gave him a dose of Ibogaine
A few days later, he realized he “wasn’t afraid” and then he realized he wasn’t having opioid withdrawals
In “Needle Park”, a park in New York, heroin addicts come there for free needles
Richie’s dream was to dose all the addicts with Ibogaine, and that only a quarter of them would show up to Needle Park because they were not addicted anymore
He brought 13 grams of Ibogaine back from Africa with him
He received a chapter from a book (Healing Journey) called Ibogaine: Fantasy and Reality by Claudio Naranjo
People were coming from all over the world to receive Ibogaine treatments
It was 15 years where he conducted over 750 psycho-spiritual and addiction-interception sessions underground
Upon training people, those people would then go and open their own treatment centers in Mexico, abroad, etc.
What is Iboga
Tabernanthe Iboga is the plant
Ibogaine Hydrochloride is the best product to use to interrupt addiction and symptoms of withdrawal from an addiction
Ibogaine is safe as long as someone has had an EKG that has been looked at very closely for any red flags
Other than cardiac risk and previous suicidality, schizophrenia, psychotic breaks there aren’t many more threats to being treated with Ibogaine
The Miracle Compound
“There is a miracle compound in ibogaine. There is nothing I have come across on the planet that can reset the biochemistry to a pre-addictive state, that can bring a person to make a choice without the agony of the symptoms of withdrawal.” – Richie
There is a 36 hour window where a person has a life review, what brought them to the addictive process in the first place, the person’s willingness and maturity
It creates a symbiotic relationship for a person to explore themselves with insight
Relapse is possible if they don’t work on the reason they became addicted in the first place
It’s the witness component that Ibogaine delivers that helps people process through their addiction
Ibogaine as a molecule has a really pharmacologically complex, alien like structure
Relapse
Justin Hoffman, a DJ in Las Vegas runs Holistic House, a facility where people get to relax and get out of their previous context for a week or two after treatment
If a family wanted to help out their family member who is addicted to heroine, Richie says that he asks the family about relocation because it’s a big part of reducing relapse
He also says that finding a proper therapist to help afterward is huge too
The combination of Ibogaine, relocation and integration therapy is the best scenario for healing someone and preventing them from relapse
Big Pharma’s Impact
Joe says how he got a message from Dana Biel, talking about how the harm reduction movement has been manipulated by the ‘Big Pharma’ industry, especially suboxone
Richie says that drugs like suboxone are prescribed to be used everyday for the rest of someone’s life, and Ibogaine is a “one-time-only” style drug that doesn’t require alot of money to heal people
Ibogaine is not profitable so its not attractive to Big Pharma
“Ibogaine will never hit the streets like LSD did. It’s not a recreational experience, it’s a long, daunting 3 stage process.” – Richie
Use Cases
He knows of a story where these two ladies took Ibogaine daily for their Parkinson’s, and as soon as they stopped taking Ibogaine, they got their symptoms back
He knows of another lady who had been walking with a cane and upon taking Ibogaine she was walking a mile around her neighborhood without her cane
Final Thoughts
Joe asks if Richie thinks we are over harvesting Iboga
There is the Wakanga tree that contains a small amount of Ibogaine, so he thinks we are okay
Ibogaine is an important subject because a lot of people are dying from opiates
Ibogaine is available in Portugal but it hasn’t had much activity
It can be used for therapeutic use as well as addiction-interruption
Richie Ogulnick is a long time Ibogaine provider and enthusiast Over the course of fifteen and a half years, he conducted about 750 sessions, including addiction-interruption treatments. He spent the next several years referring close to 1,000 more people to other ibogaine providers. During that time, he also trained doctors and ex-addicts who opened ibogaine centers throughout the world. Richie feels a pull to focus again on the more therapeutic and psycho-spiritual treatments where he is able to offer his expertise in ibogaine treatment along with his knowledge of reintegration with individuals who are looking to deepen and enrich their life experience.
In this Episode, Joe interviews Brad Burge, Director of Strategic Communications at MAPS. In this episode they discuss the Phase 3 Trial for MDMA Assisted Psychotherapy, contradictions and Expanded Access.
3 Key Points:
MAPS is about to run Phase 3 Trials of MDMA Assisted Psychotherapy
If MDMA passes this third phase, it will still be tricky to get insurance involved. But the cost of one series of MDMA Therapy is much cheaper than a lifetime of typical pharmaceutical drugs and therapy sessions to heal PTSD.
The only reason for-profit companies haven’t gotten involved before was because there wasn’t a promise on their investment. Finally, for-profit companies (like Compass Pathways) are interested in advancing these medicines (Psilocybin and MDMA).
After phase 3 trials, if all goes well, it would mean that MDMA would be the drug to be used (only) alongside Psychotherapy
MAPS is training therapists, counselors and social workers
One way to get more people educated who are interested in this would be taking therapy interns in and having them gain credits for interning and learning alongside trained therapists
Access
Expanded Access is known as ‘compassionate use’, a program by the FDA that allows people to receive a treatment that is still in trials
In order to administer the therapy you are required to get a DEA schedule 1 license
“If there’s one thing that changes public perspective on psychedelic therapy, its individual stories of people who have been healed, transformed by or positively or even negatively affected by them in some way” – Brad
They have published many studies of the trials
The most recent was the Boulder study, 76% of people didn’t have PTSD a year after MDMA assisted therapy
Insurance won’t cover expanded access, it will have to pass Phase 3 trials until insurance can be used in MDMA Assisted Psychotherapy
The MDMA is a very small cost (fraction) of the total cost, it’s the hours on hours of psychotherapy that cost so much
But the cost of one MDMA Therapy Session process is much cheaper than a lifetime of pharmaceutical drugs and therapy sessions to heal PTSD
Argument
Joe says he hears this strange argument that people say “giving soldiers MDMA just makes war easier”
Brad says it’s not about putting these people back into war, it’s about healing the retired veterans to help them adapt back into their everyday life
“MDMA Assisted Psychotherapy is going to make them a better lover not a better fighter” – Brad
“If there’s one commonality in psychedelic experiences, its that things are connected.” – Brad
Compass Pathways
Joe mentions that people are scared to see a business come in that’s acting like a normal pharmaceutical company
MAPS is not tied at all with Compass Pathways
Out of the top two things Americans are mad about, at least one of them is the Pharmaceutical Industry
Finally, for-profit companies are interested in advancing these medicines (MDMA)
The only reason for-profit companies haven’t gotten involved before was because there wasn’t a promise on their investment
Capitalism has a tendency to put profit first
“Money can be used for good as well as evil” – Brad
MAPS has raised over 70 billion dollars all from donations
Compass owns its own safety data
Part of the goal of a patent is to protect the investment
Zendo Project
MAPS Psychedelic Harm Reduction and Peer Support resource
Brad Burge is Director of Strategic Communications at the non-profit Multidisciplinary Association for Psychedelic Studies (MAPS). Brad earned his B.A. in Communication and Psychology from Stanford University in 2005 and his M.A. in Communication from the University of California, San Diego in 2009. He began working with MAPS in 2009, where he engages daily with journalists and media producers around the world to enhance public knowledge about psychedelic research, while also helping develop and evolve MAPS’ brand and outreach strategy. Brad is passionate about finding healthier, more effective, and more compassionate ways for humans to work with the pharmaceutical and digital communications technologies of the 21st century. When he’s not plugged in, you’ll find him in the mountains, carrying a backpack, somewhere down a long trail.
In this episode, Joe interviews Nathan Sepeda, a Research Coordinator at Johns Hopkins. Joe and Nathan cover topics on 5-MEO-DMT research and survey studies, the difference between synthetic and toad sourced 5-MEO-DMT, the sustainability of the Bufo Alvarius toad, and the benefits of a proper facilitator.
3 Key Points:
5-MEO-DMT is starting to gain traction in the research world. The conversation continues on whether the synthetic 5-MEO-DMT experience is any different from a 5-MEO-DMT experience sourced from the toad venom.
As the popularity of 5-MEO-DMT increases, concerns about the wellbeing and sustainability of the Bufo Alvarius toad also increases.
Proper facilitation has been shown to affect a person’s experience on a substance like 5-MEO-DMT. The use of a practitioner, finding the substance from a reputable source, and integration all play a critical role in the user’s experience.
Joe found out about Nathan Sepeda and the work being done on 5-MEO-DMT after Johns Hopkins released a poster on 5-MEO-DMT
Alan Davis put together a survey about people’s 5-MEO-DMT experiences
Half of the use was recreational, and then the other half of survey participants used more of a therapeutic approach set and setting including a sitter and integration
The study found that the more structured the 5-MEO-DMT experience was around set and setting, the more often participants reported a more mystical experience as well as a lower likelihood of having a difficult experience
The survey only looked at synthetic 5-MEO-DMT
Using 5-MEO-DMT from a toad also runs the risk of the other toad venom constituents
Joe said the first time he heard about data on 5-MEO-DMT was at the Oakland Psychedelic Science Conference in 2017
Stan Grof had a keynote saying that 5-MEO-DMT was the future of psychiatry
Toad Conservation
The Bufo Alvarius toad’s population is increasingly declining
Joe says he knows someone who lives on the Mexican border in the Sonoran desert, and he would have toads jump into his house all the time
He doesn’t even see them anymore
Joe also mentions the toads flocking to the UV street lights, and people scooping them up or even running them over
“How do we do less harm to living things and treat our environment better?” – Joe
Nathan’s Role at Hopkins
Nathan is the Research Coordinator of Psychedelic Studies at Johns Hopkins
He works as an Assistant Facilitator (sitter) for the psychoactive drug sessions
He is involved in Psilocybin studies (currently the depression study)
He says he is grateful to be a part of the research, seeing people change in a matter of days from the help of the substances
Nathan has a background in Psychology and Neuroscience
Mary Cosimano is the primary facilitator for all of the studies at Johns Hopkins
His training consisted of mock sessions, ways to ask/answer questions, and overall hold the space
A lot of people will describe their experience being the most spiritual experience of their life
Joe asks about upset stomach with synthetic psilocybin
Nathan responds saying they ask patients to eat a light breakfast, but he never really sees upset stomach with synthetic psilocybin
Proper Facilitation
The use of a practitioner and finding the substance from a reputable source are the two biggest factors in having a great experience, along with integration
Nathan says that these findings are preliminary but they are a great start to data on the substance and its use
Joe says he is cautious about the religious affiliation people prescribe to their experience with these substances
It can get out of hand, there are “shamans” that taze people or throw buckets of cold water on their patients when they are on the substance
Waterboarding, sexual assault, all of these things speak to the value of screening practitioners
Joe has heard about a facilitator using an extremely high amount of 5-MEO-DMT on his patients, far above the effective dose
Joe mentions a story about a “shaman” who was to facilitate a session. The participant thought they were going to do standard DMT, and the shaman gave them 5-MEO-DMT instead (without the users consent)
Joe suggests that just because you know a reputable source for a substance, doesn’t mean they are a good facilitator
Nathan Sepeda is an assistant facilitator (or guide) for psychoactive drug sessions and research coordinator for the Johns Hopkins Psychedelic Research Unit. Nathan earned an undergraduate degree from the University of Minnesota studying psychology and neuroscience. His interests in addiction and mood disorders, in combination with the promising research with psychedelics, have led Nathan to Dr. Roland Griffiths’ lab. Nathan is involved in a number of projects investigating the effects of various psychedelic substances, including psilocybin, salvinorin-A, and 5-MeO-DMT.
In this unique episode, Joe brings Tom Hatsis and Dr. Jerry Brown together for a psychedelic debate. They go back in forth in conversation on whether there was psychedelic use in medieval or ancient Christianity and if so, was there a secret tradition of including art of mushrooms or psychedelic substances in cathedrals and castles.
3 Key Points:
Jerry Brown makes the claim that there is evidence of visionary plants in Christianity and the life of Jesus found in medieval art and biblical scripture.
Tom Hatsis makes the claim that Christianity is not hiding a giant secret inside the biblical texts about the true hallucinogen at the root of the religion being an Amanita Muscaria.
Jerry and Tom debate back and forth, pulling from art and textual evidence (and lack thereof) to support or deny the claim that Psychedelic Mushrooms are the root of Christian religion.
Anthropologist, Author and Activist
Served as the Prof of Anthropology at FIU in Miami
He designed and taught a course on hallucinogens and culture
He is the Co-Author of Sacred Plants and the Gnostic Church: Speculations on Entheogen use in Early Christian Ritual The Psychedelic Gospels: The Secret History of Hallucinogens in Christianity
Tom Hatsis
Author, Public Speaker, Roller Derby Player and Potion Maker
He is the Author of three books in Psychedelia;
The Witches Ointment: the Secret History of Psychedelic Magic
Psychedelic Mystery Traditions; Spirit Plants, Magical Practices and Psychedelic States Microdosing Magic: A Psychedelic Spellbook
Partnered with event organizer and short film maker, Eden Woodruff, who runs Psanctum Psychedelia in Portland in the process of winning the Guinness Book of World Record in Magic
Intro
The debate is around the early Christian use of psychedelics and mushrooms in Christian art
The conversation is on the validity on whether or not psychedelics were used in early Christianity
Dr. Jerry Brown on Psychedelics in Christianity
The Miracle of Marsh Chapel – a double-blind experiment conducted by Walter Pahnky in 1962 where 20 students were divided into two groups, half received niacin and the other half received psilocybin
9 out of 10 who took psilocybin had a profound psychedelic experience
Brown explains that this is an important part in the entire history of psychedelics
After discovering the Amanita Muscaria mushroom (confirmed by Paul Stamets) in a 15th Century Church in Scotland, he realized that there were many entheogenic images in Christian art
He says that most church historians do not have training in mycology to recognize entheogens and mushrooms
He brings up an image of Adam and Eve standing next to a large Amanita Muscaria mushroom
He went to a Parish Church and saw an image of Jesus entering Jerusalem on a Donkey, and one of the youths welcoming Jesus is holding a long mushroom cap
He went to churches in England, Germany and France
In the drawing of Genesis, he saw God creating plants (psilocybin mushrooms)
“When you go back beyond the 3rd century, there are no visual images or Christian art due to poverty and persecution” – Jerry
Jerry reads a passage,
“Jesus said to his disciples, “compare me to someone and tell me who I am like” Thomas said to him, “Master, my mouth is wholly incapable of saying whom you are like.” Jesus said “I am not your master, because you have drunk you have become intoxicated from the bubbling wellspring that I have personally measured out. He who will drink from my mouth will become like me, I shall become like he, and the things that are hidden, should be revealed to him.”
He interprets the passage as a reference to drinking a psychoactive mushroom substance
Jerry goes on to explain that Jesus realized his feeling of eternal life through the use of psychoactive entheogens
He says that this is not a means of dismissing Christianity, but instead to reintroduce Christianity with its original roots
Tom Hatsis on Psychedelics in Christianity
Tom says that Jerry makes a lot of assertions, but does not present any evidence. He talks about art, but not anything in scripture
Tom is curious why the only artwork that Jerry brings his assertions about mushrooms are from a time where we can’t ask them about it
Tom brings up Julie and Jerry’s book and that the first chapter has nothing to do with Christian History at all
Tom uses an example of stone mushrooms. Someone doing a cross cultural analysis, might agree that they are mushrooms based on the other findings of cannabis and opioids
But, as a historian, Tom looks for evidence and in this case, there are eye witness accounts of its use
He brings up the example, the infamous plaincourault fresco of Adam and Eve at the tree of good and evil with the forbidden fruit
Using this one example, he wants to prove how critical historical methodology is used to prove unsubstantiated claims on Christian art as wrong
The paradise tree is a mix of the tree of knowledge of good and evil and a symbol of Christ’s victory over Adam’s transgression. In the play, it was tradition to place small Eucharist wafers on the tree branches so that’s what the white dots are on the tree branches
The tree’s shape is not a mushroom cap, it is a parasol of victory
Jerry’s Rebuttle
Jerry says that the absence of evidence, is not equal, or proof of evidence of absence (just because it’s not written in text, doesn’t mean that its not there in the art)
Jerry’s issue with the fresco is that “The Fall” is a New Testament creation, not all the way back in Genesis
He says that on their website, they do not ‘alter’ the image, they ‘enhance’ it
He says that Tom claims the fruit doesn’t matter, but the fruit does matter (it could be a psychedelic mushroom)
He touches on the skeletal appearance of Eve and the meaning of renewal of life
Jerry thinks this image is the beginning of the religious experience and symbolism that the soul is immortal and will continue to exist after death
He says the serpent is not a depiction of evil entering Eden, but instead a source of knowledge and a spiritual guide to the feminine to help bring man into higher awareness
Tom’s Rebuttle
Tom says he didn’t hear any evidence from Jerry, he heard arguments to authority
He says that Jerry uses anthropology to uncover history, and opinions of art historians, but medieval historians agree that the mushroom is not present in Christian art
He also says he did agree with Jerry about the mushroom in art, but that was last year and he has proven himself wrong and that the mushroom caps are parasols of victory
Jerry says that Amanita Muscaria was in the Soma, but Tom says cannabis was, and mushrooms were not Chris Bennett’s book on Soma
There is zero evidence for mushroom art during medieval times
In Jerry’s book, he writes about the Basilica di Aquilea, saying that they are Amanita Muscaria, but Tom says they are not that type of mushroom
Tom also says that in the play depicted in the plaincourault, that the script literally says the wafers are hung on the tree, and that the little white dots are not the dots from an Amanita Muscaria
Jerry’s Closing Remarks
He says that this isn’t just cultural analysis, this is about fieldwork and looking at how native people view this artwork
The problem he has with Tom and Church historians is that it is not taking evidence from Ethnobotanists
Jerry says he believes that there is a long tradition of entheogenic mushrooms in Christian art and would like this debate to continue
Tom’s Closing Remarks
Tom says he still isn’t hearing evidence, he is only hearing assertions and argument to authority and eminent scholars
Tom says that Genesis doesn’t matter in the plaincourault, because we know that it’s about the play
He has multiple articles debunking these images on his website
Check out our online course, “Introduction to Psychedelics”
About Jerry
Jerry B. Brown, Ph.D., is an anthropologist, author and activist. From 1972-2014, he served as Founding Professor of Anthropology at Florida International University in Miami, where he designed and taught a course on “Hallucinogens and Culture.” The course examines the use of psychoactive plants by tribal and classical cultures, including Ancient India and Greece, and by and discusses the discoveries of the modern mind-explorers, the “psychonauts of the twentieth century.”
About Tom
Thomas Hatsis is an author, lecturer, and historian of witchcraft, magic, Western religions, contemporary psychedelia, entheogens, and medieval pharmacopeia. In his spare time he visits rare archives, slings elixirs, and coaches roller derby.
In this episode, Joe interviews Steve Hupp, the Host of Kentucky Ayahuasca, a new series on Viceland. Topics include Steve’s background and how he wants to impact the American Ayahuasca scene through his work.
3 Key Points:
Kentucky Ayahuasca is a docu-series on Viceland about Shaman, Steve Hupp as he works with people seeking healing from severe emotional and physical issues.
Steve comes from an unusual background of career criminal and bank robber, and because of his time in prison with a Peruvian Shaman, has decided to bring the tradition to the United States.
Steve is careful not to mock what shamanism is by creating ceremony in the States. He wants facilitation to be done as safely as possible and is simply trying to help people through Ayahuasca ceremony.
It landed him in prison and put him into the same cell of a Peruvian shaman who had overstayed his visa and was probably doing some facilitating in the States
His name was Guadalupe and Steve called him Loopy because of the things he was talking about
But here and there Guadalupe would say something that would resonate with Steve days and weeks later that just made sense
Prison
He spent 4 years in prison
He got into the federal system because he had beaten the state system so the federal system picked up the case
Steve pleaded guilty and made a deal with them to give them their money back
He also agreed not to sue the police for opening fire on him
He was one of the first bank robbers released on a bond
Religion and Spirituality
Up to that point he was an Atheist
He decided that something else was keeping him alive for something because of what he survived during the police chase
Steve says he’s seen how religious law worked by seeing gangs turn into congregations
He says he is no longer an Atheist after having experience with Ayahuasca
He had an epiphany that “anything is possible” and he decided he wanted to bring this to everyone
He started to have coincidences that led him to facilitation
Shamanism
Steve isn’t trying to defraud what Shamanism is, but he is trying to tailor it to the American way of life
He says the Shaman in the jungle has a different context than an American does
Joe mentions that people get upset about how the word ‘shaman’ is used
Steve says ‘shaman’ comes from the Siberian word, ‘saman’, which means “to know” but has been branded by anthropologists
He also says shamanism is the oldest world religion
Joe brings up that so many people suggest doing Ayahuasca in the Amazon because that’s where the spirit of the plant is, but he also mentions that the same type of biodiversity exists in Kentucky too
Purpose
Steve says they face reverse-racism because they can’t work with native tribes because they are white, but he’s just looking to bring everyone together
“If we don’t start helping our little blue sphere heal, it’s all we’ve got” – Steve
He said he had more fear transitioning into Ayahuasca facilitation than any bank he’s robbed because he had to put his name on it
His intent is not to build a cult, he believes we are at the dawn of a new world and we are all in this together
Helping Addiction with Ayahuasca
Steve says he believes there are no addicts, just unbalanced humans
Joe says he read recently that the term “addict” keeps people in their problems
When he helps people who are addicted to drugs, and they drink Ayahuasca, they realize the drug is not the problem, but the guilt and the shame about using the drug is the problem
Plant Teacher
Steve believes we are intergalactic children
We could use our technology and knowledge to better us rather than being so distracted by the ‘lines in the sand’
He says we could feed everyone on the planet with land the size of Texas
What Ayahuasca is trying to teach us is to be kind to each other and we have that choice everyday
We need to get past this barbaric attitude of domination
“I know I’ve got grandchildren that I may never see, but I’ve got to try to leave them a world better than the one I’ve found” – Steve
If we were to teach our kids to teach our grandkids something, we wouldn’t be handing them millions of dollars in national debt
Its a non-violent change
“What if we collectively manifested accountability in our government?” – Steve
Law Enforcement
Steve believes law enforcement shouldn’t be able to have more power than soldiers at war
Soldiers in Iraq can’t fire unless they have been fired upon
Shaman University
No one has ever done this before, Steve wants to put together a structure to make sure this operation is done ethically
He wants to lay the foundation for people to participate in Ayahuasca ceremony safely
He says anybody can brew Ayahuasca, but doing it safely and properly is key
Joe encourages viewers to check out the series on Viceland
Steve also encourages listeners who want to do Ayahuasca abroad to do tons of research before attending to make sure there are proper facilitators, ethical procedures and quality emergency response techniques and resources
Check out our online course, “Introduction to Psychedelics”
About Steve
Steve Hupp had spent time in the Military. He was lost in materialism, drug abuse, alcoholism and pride that led him on a 5 year bank robbing spree that ended with him in Federal Prison, where he met his first Shaman, a cellmate. Now he is an Ayahuasca Shaman performing psychedelic healing ceremonies in Kentucky. Steve has worked with Ayahuasca for 15 years, trained by a Shaman from South America on how to work with Ayahuasca. He has spent much of that time working alone and experiencing many visions and entities that called him to found Aya Quest.
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In this episode, Joe and Kyle interview Jake Mitchell from the Flight of Thoughts Podcast.
Jake has spent 4 years as a Paramedic in Canada and leads trainings around mental health, first aid and is bringing better practice of psychedelics into the psychedelic space.
3 Key Points:
It’s so important to know your substances and get a testing kit so you know its not laced and you know exactly what you’re taking.
More people seek help when they look at an overdose or a difficult experience as if they are suffering versus breaking the law. Decriminalization at the least, would help make people be seen as a patient and not a criminal.
Most police aren’t trained on mental health issues, and they have shot and killed people because they don’t know how to correctly respond to issues like schizophrenia. We need more mental health training among our law enforcement.
He had major depression and didn’t know it, and started to use cannabis as a useful tool for his depression
He started to notice some of the first responders use MDMA and Psilocybin off-duty to help with their PTSD
“PTSD for those who have been in combat is more understood than for first responders with it, people think that we can just handle it.” – Jake
There are levels of trauma that don’t qualify daily for PTSD, but for police and firefighters and such, they can be triggered by certain events
It’s hard to say what percentage of first responders use cannabis, MDMA and psilocybin for personal therapeutic use
Jake says he knows of at least a quarter of first responders who have been open about their use
There is a new initiative that if police use cannabis, even right before their shift, as long as they are ‘fit for duty’ they won’t be scrutinized
CBD
CBD counteracts the effects of THC, THC binds to CB1 receptors, and CBD binds to CB2 receptors
CBD is similar to Advil
If someone has taken too many edibles, they can take Advil to counteract the effect of the THC
It counteracts the THC similar to how CBD does
People used to say to have a good night, eat a pot brownie, but it’s a better idea to smoke for the first time than to eat an edible
Harm Reduction – Teaching People How to Respond to Overdose
They are teaching people about harm reduction kits or when to call an ambulance
Know your substances, and get a testing kit so you know its not laced and you know exactly what you’re taking
Know what breathing technique you want to use if you “feel the fear” setting in
If you know someone is on a clean substance, you can try to help them through it, but if it could be laced (with fentanyl, etc) call an ambulance
If someone is unresponsive, that’s a sign they could be overdosing
You can rub as hard as you can with your knuckles on their chest and scream their name, and if they don’t wake up, that’s a good sign to call 911
Always turn them on their side so that their air passages open up and they don’t asphyxiate on their tongue or vomit
If you are informed on how to use narcan and you think they are overdosing on fentanyl, use it
If they are awake and are psychologically freaking out, just sit them down and simply ask them “how can I help?” They might want something as simple as some water or to go for a walk
Knowing your dose is so important
LSD and psilocybin don’t have cardiac effects, they don’t shut off breathing, so you shouldn’t have a reason for feeling like your going to actually die unless it’s been laced
MDMA is one you have so worry about but you’d have to take hundreds and hundreds of milligrams
Usually the only reason that people overdose on heroin is because it’s laced with pharmaceuticals
Advil and Tylenol work similar to opioids
Sometimes we have emotional trauma and it comes out as physical pain
More people seek help when they look at it as that they are suffering versus breaking the law
Narcan costs $20-$40
An overdose death costs $30,000
In Canada, the pharmacist will inform you on how to use Narcan
Jake says he hopes that the US will catch up Narcan availability and use
The grinding of the teeth after taking MDMA may be a sign that it contains amphetamine
Decriminalization at the least, would help make people be seen as a patient and not a criminal
A Healthcare Issue, Not a Crime
The Good Samaritan Act in Canada says if you have minor possession of a substance and not a traffic-able amount, and you call the ambulance for an overdose, you will not be searched or charged
Most police aren’t trained on mental health issues, and there have been situations of people with schizophrenia having a moment in public, and because the police don’t have education on signs to look for, they have shot and killed the victim
23 and Me, the gene testing company, tested over 180,000 people’s genes in a sample
The findings showed that cannabis doesn’t cause schizophrenia, but people likely use cannabis to relieve symptoms of it
Serotonin Toxicity
Jake says he’s been hit in the face by someone on PCP
It took 6 police to hold one person down.
Another time, there was a guy who was wearing underwear in freezing weather, punching cars driving at almost 40 miles an hour
They were snorting Wellbutrin, an antidepressant that works as a stimulant when snorted
Serotonin syndrome is super dangerous
Ketamine is used in the ER for scenarios like this
Does taking MDMA too frequently ruin your serotonin system?
Emanuel Sferios – the number one risk of using MDMA is you might not get high from it anymore
Addiction
Type II Diabetes is a symptom of sugar addiction
Sugar and carbs create bacteria in the gut that releases plaque in the blood
Technology addiction – Jake had a patient that sliced an artery and was texting and on candy crush and Snapchat
Check out this FREE online course, “Introduction to Psychedelics”
About Jake
Jake is a Primary Care Paramedic with experience in emergency response, evidence-based research practice, harm reduction techniques, and crisis intervention. He is the Founder of The Psychedelic Society of First Responders and Emergency Workers.
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In this interview, Brian Pace interviews Dr. Jason Slot at Ohio State University. In the show, they talk about Jason’s contributions of the psilocybe genus. Jason is in the faculty at OSU in the department of plant pathology.
3 Key Points:
There are over 200 species of mushroom forming fungi that produce psilocybin, and Jason studies how and why these organisms produce the psychoactive compound.
Animals seek altered states of consciousness as a potential evolutionary mechanism.
Mushrooms use horizontal gene transfer to pass on their psychoactive properties.
“There weren’t many mycology job postings in the area, and a job came up for someone to study the evolution of fungal genomes” – Jason
It all just fell into place
What is Neurochemical Ecology
Ecology is the interaction among organisms and their interaction with their environment
Neurochemical ecology is a special case where the chemicals are specifically targeted to processes of nervous systems in animals
There is an opportunity for plants and fungi to produce drugs and compounds that manipulate their behavior or inhibit their eating
Species that Produce Psilocybin
There are over 200 species of mushroom forming fungi that produce psilocybin
Jason has found many more
Distribution of Psilocybe
Mushrooms were anatomically modern
There were flowering forests and wood that spanned to each of the poles
The supercontinent would have broken up after that and as the continents separated, so did the mushrooms
Humans have been distributing psilocybe through the dung of migrating animals
Columbian Exchange
During colonization from the old world to the new world, there was the biggest exchange of fungi
If the amount of biomass and dung expands, then the number of fungi species evolves and grows
The underlying change in the climate that changes the planet from forested to open grasslands also has an impact
During human evolution, psilocybe has been around the whole time
These neurochemicals have dated human genus
Serotonin
Serotonin is analogous to psilocybin
Bacteria was the first organism making serotonin
Insects produce serotonin
“Serotonin is a great key, it fits into a lot of different locks and is used in a lot of different ways” – Jason
It’s in plants, its in amoebas, and its in animals
In animals, they have specialized a lot of different receptors that respond to serotonin
Serotonin only interacts with one type of receptor in the body
Altered States of Consciousness
“It must be like something to be a bat, and it must be different than what it’s like to be a human, what must it be like to be a bat under the influence of psilocybin, is it anything like a human?” -Brian
Animals seek altered states of consciousness
Bees seek out fermented grapes
We have video footage of foxes taking huge bites out of Amanita Muscaria
Seeking out intoxication is a natural human drive
Maybe the desire to seek out these altered states of consciousness is an evolutionary mechanism that is happening
If you search out new ways of perceiving the world, you may come upon a new pattern that your group of species learns how to live better
If ants come back to the hive too drunk, they get punished and get bit
Language
One of the ways humans distinguish ourselves
We have specialized vocal chords, and tongues that make our language unique
Terrence – Stoned Ape Theory – the thesis was that psilocybin mushrooms were a part of the diets of the hominids
There was some kind of co-evolutionary relationship that may have resulted in human language
Psilocybin’s role in our development
“What kind of role did psilocybin mushrooms play in our development?”
The hominids came down from the trees and now they are standing upright
We have to look at opportunity, constraints, etc.
If the ape eats psilocybin, it may have an idea or understands its environment better
It may help the ape acquire more food or expand into new territory
The access to food and changes in locomotion are huge forces in our evolution
Having fire to cook our meat and change our availability to nutrients is one of the biggest forces in evolution of human consciousness than mushrooms
Horizontal Gene Transfer
Vertical transfer of information means from parent to offspring
Horizontal transfer of genetic information happens between species
One bacteria has a gene to resist an antibiotic, and another doesn’t. One bacteria can obtain that gene from the antibiotic resistant bacteria (ex. Antibiotic-resistant staphylococcus)
Gene transfer can happen in multicellular creatures like mushrooms
Fungi are exchanging genes through different species
Paneolis Mushrooms did not inherit the biosynthetic pathway to produce psilocybin, they received it from a totally different genera
KT Extinction
A comet impact that caused havoc and climate change that resulted in the extinction of dinosaurs
Mega herbivores, putting out tons of herbivore dung
The genes to make psilocybin were acquired by a dung loving Paneolis from a dung loving Psilocybe
Dung attracts flies, but it doesn’t kill the insects that eat psilocybin
Psilocybin is one of the safest drugs for consumption
The amatoxin in Amanita Muscaria (The Destroying Angel, commonly mistaken with Matsutake), interrupts the central part of cellular metabolism
Identifying Genes in Psilocybin
He sequenced 3 different species of mushrooms that make psilocybin, and then looked at one species that didn’t make psilocybin
They take two pieces of DNA and then compare them
They all have those genes, but how did they get them?
Validated the biosynthesis of psilocybin
Mediated Horizontal Gene Transfer
When fungi are under stress they take the DNA from their environment
Cicada Parasitism
There are cicada pathogens that infect the cicadas before they emerge from their ‘underground’ and their rear end is transformed into these spore producing structures
They fly around and drop their spores all over
Are these plants or fungi are using any of these neurochemicals in house for cognition?
Turing test – a computer can convince you that it’s human
Check out this FREE online course, “Introduction to Psychedelics”
About Jason
Jason Slot is an Evolutionary Biologist that studies topics in three major areas, the genomic and metabolic bases of fungal adaptation and niche, horizontal gene transfer mechanisms and the evolution of symbioses. He is in the Department of Plant Pathology at Ohio State University.
This is an edited transcript from a podcast that was recorded live in Bolten Valley, Vermont for a MAPS Psychedelic Dinner event in May 2016.
When I met Albert Hofmann, I introduced myself to him by telling him my birthday, which was April 17, 1943. He burst out laughing.
– Lenny Gibson
There are three modern turning points in the modern history of psychedelics. The first one being when Albert Hofmann had the experience that led him to realize the psychotropic properties of the substance he had synthesized. The second one was when Gordon Wasson and his wife, Valentina, connected with Maria Sabina, who was a curandera who used mushrooms. This event resulted in the introduction of psilocybin, in addition to LSD. The third turning point was when Hoffman and Wasson were together, and Hoffman synthesized psilocybin. Psilocybin became readily available, instead of having to go to some obscure place in Mexico to beg people to find somebody who knew where to get the mushrooms.
Greek History
The use of substances in providing transcendent experiences goes back beyond the beginnings of our written history in the west. The shamanic tradition in Greece led to the development of the tragic plays – The great tragic plays of Sophocles and Aeschylus. The Greek word tragedy, literally means goatskin, because in the festivals of Dionysus, who was the god of wine, when the new wine was decanted everybody got really high on the new wine. It gave people permission to act like goats and as you know Dionysus was portrayed as half man and half goat. Dionysus had also been to the underworld and back, like Orpheus, another person that comes out of the shamanic traditions and into, what we call, the Greek Mystery Religions. The most prominent of the Mystery religions was one called the Eleusinian Mysteries, a mystery not in the sense of Ellery Queen, but a mystery in the sense of mystical. That rite goes back beyond recorded time and lasted for, at least, two thousand years. It was a rite built around the myth of Demeter and Persephone.
Persephone was out picking flowers in the meadow on a spring day and Hades came along and grabbed her, took her down into the underworld. Demeter, her mother, was distraught but Persephone was gone. Demeter appealed to the other gods for help getting Persephone back. It was of no use. So finally, Demeter since she was the goddess of agriculture and growing things, decided that she would stop everything growing. Clearly a symptom of depression.
It didn’t bother the gods because they lived on Ambrosia. But then it occurred to them that if the human beings starved to death there’d be no one to worship the gods. That got to them and they agreed to help Demeter and prevailed upon Hades to let Persephone come back, but she had sampled maybe one or seven seeds from a pomegranate. The way those myths work, she couldn’t be completely freed of Hades and had to, ended up spending half her time in Hades and half with her mother. Thus, the variation of the seasons. So the myth is about going into the underworld and coming back, basically, about death and rebirth. It appears to have involved an ergot-derived substance, a psychedelic. We don’t know exactly because the Eleusis were sworn to secrecy and the secret was never revealed – two thousand years. All of the major people, all the intelligentsia, many of the regular people of Greece were initiates. They could do it once. Pindar, the famous poet, who was also an initiate, along with Plato and Xenophon and the whole, even to the Romans, Cicero was an initiate. Marcus Aurelius was the last Roman Emperor, was an initiate. The whole thing [The Eleusinian Mysteries] was killed when Calvin Constantine converted the Roman Empire to Christianity. Pindar says, not revealing a secret, but says of the right, it was an experience dying before dying. But as I said, Constantine saw the Ring of Fire and decided that the Roman Empire should become Christian, they should stop persecuting the Christians and become part of it. And so Christianity doesn’t have a very good track record with substances other than wine and Eucharist, which are psychedelic for a very limited group of people who are intensely into the sacred technology of the mass.
Huxley and Humphry Osmond
So the middle ages is a kind of, in the west, it’s a kind of desert, as far as psychedelics are concerned. And we don’t really find anything of interest until we jump up to the 19th century. Havelock Ellis took peyote on Good Friday, 1897. He wrote it up for the British Journal of Medicine, they rejected it – too fantastical. His other major work, which was in The Psychology of Sex, seven volumes – sold very well. He gave some peyote buttons to William Butler Yates, who realized that we’re all slouching towards Bethlehem.
Humphry Osmond worked a little mental hospital up in Saskatchewan and began experimenting with LSD [and mescaline]. Aldous Huxley somehow learned of this work and said, “If you’re in LA, come by and see me.” Osmond didn’t think it would ever happen, but in fact, there was a bureaucratic problem at the hospital. They needed to reorganize and move Osmond up and get rid of the guy that was above him, and so while they were doing that, they sent Osmond off to an APA convention in LA – where he got in touch with Huxley. They went to a few sessions of the APA convention and were bored to tears. So they adjourned back to Huxley’s place and Osmond turned him on. It took about 90 minutes before it really hit him and then it blew his mind. Huxley was the author of Brave New World andApe and Essence. Huxley was one of the major intellectuals in the 20th century and an enormously successful author, half blind, but intensely intellectual. He was part of a circle of people that stretches back really to Havelock Ellis and Hermann Hesse [Who wrote Siddhartha andThe Glass Bead Game ], and Carl Jung.
But the psychedelic experience was restricted to a very small elite. Huxley, upon trying the mescaline, called it the most extraordinary and significant experience available to human beings this side of the beatific vision. (The Doors of Perception, he produced as a result of it.) In there, he mentions CD Broad, a British philosopher who characterizes the brain as a cerebral reducing valve. Huxley’s first theories here was that psychedelics eliminate some of the filterings of the brain. Fairly crude though, we have a lot more sophisticated stuff now. Robin Carhart-Harris has advanced that considerably.
Huxley was also friends with a fellow named Gerald Heard, who was again, a major intellectual personage in the early-mid 20th century. The two of them eventually came into contact with a guy named Al Hubbard, nicknamed Cappy, because he was the President of the Vancouver Yacht Club and also the Uranium Corporation in Vancouver. He is best described as a kind peripatetic imp. He rode off to Sandoz and got a huge supply of LSD and I guess carted around the world turning people on but kept it limited to a very small group of people like this.
There’s Gerald Heard, there’s Oscar Janiger, who was a psychiatrist in Beverly Hills, who found out about LSD, got a large supply of it and a group around him Huxley, Heard, Hubbard, Janiger, Sidney Cohen, they were involved in a salon in the LA area. Their recording secretary was Anais Nin. Janiger also obtained DMT and introduced that into the whole thing.
Humphry Osmond first proposed the term psychedelic at a meeting of the New York Academy of Sciences in 1957. He said the word meant “mind manifested” from the two Greek words for psyche and delos, which means clear. Huxley had sent Osmond a rhyme, which went, “To make this trivial world sublime, take a half a gram of phanerothyme. Thumos means spiritedness in Greek. Osmond wrote back, “The fathom hell or sore angelic, just a take a pinch of psychedelic.”
Tim Leary
Now until Tim Leary came along, the psychedelic usage, although it was a growing circle, was pretty much limited to a fairly elite circle, a circle of intellectuals and a few housewives, as you saw before. But then Timothy Leary got a hold of psilocybin and this is a major turning point because Tim Leary couldn’t contain himself. And, in some ways, he advanced things enormously and in other ways, he set them back terribly. But certainly, and there you see him in some of his many guises.
The basic issue was he had started out doing reasonable research at Harvard and he couldn’t keep it in and started spewing it out. So you get the stuff starting to come out into settings that are not conducive to people getting the best out of it. And he became involved with these folks – Good old Alan, William Burroughs, some of you may know he was heir to the Burroughs fortune, the Burroughs adding machine.
So, here we have these guys, Kerouac, On the Road, and Alan Watts, who was a great talker. So East Coast, we’ve got Tim Leary, and West Coast we got, Ken Kesey, Neal Cassady, coming out of on the road.
There’s the bus, the first acid tests, which morphed into the trip festivals, which morphed into Burning Man. The first Human Be-In and down there in the corner is one of the sponsors, Augustus Stanley Owsley III, who had a girlfriend who was good at making LSD and he produced zillions of doses really cheap.
But we have some problems here, the war. Psychedelics and the anti-war movement started synergizing each other and the government got really scared.
They (the government) had been interested in LSD early on. There was a guy named James Moore who accompanied Wasson (Gordon and Valentina) to Mexico under the pretext of being the photographer on one of those CIA plans. He (Moore) brought psilocybin back to back to the CIA. They were interested in it because it having mind effects – they discovered when they gave it to the spies, those hardened spooks ended up over in the corner weeping and crying about brotherly love. Other than the ones that ran frantically out of the room and had to be chased down in Virginia where they were found under a fountain talking about those terrible eyes and the monsters that were insulting them. So, it didn’t work out for the CIA.
Prohibition – California criminalized LSD on October 7th, 1966 and that’s when things started to head down because it drove it underground and that’s the worst thing you can do. I mean, prohibition, it’s like, “Will we ever learn?” We tried prohibition with alcohol. When I lived in Oklahoma, one of the lines there was, “It was so dry.” There were some dry counties in Oklahoma in the 1970’s, and the line was, “They would remain dry as long as the Baptists and the bootleggers could stagger to the poles.” It (psychedelics) went underground and at the same time proliferated.
Sasha Shulgin, wonderful man, wonderful, wonderful man. He could give a lecture on chemistry that was just if you didn’t know a bit about chemistry you would be fascinated. And there he is with his wife Ann and immortalized by Alex Grey. And there’s one of his “dirty pictures” down there in the corner, he called them dirty pictures, the molecules. There’s a great video on YouTube about Sasha called, Dirty Pictures, wonderful video.
And here are other folks – Richard Alpert, of course, was with Tim Leary at Harvard early on, but they diverged, India took on Alpert but it didn’t take on Tim. And we see Alpert in an early phase down there in the corner, we see him in his post-India phase when he turned back into just an ordinary transcendental. We have the intellectualization of Ken Wilbur, and we have a leprechaun fully as filled with impishness as was Cappy, Terry McKenna. That book (Be Here Now), I remember going to the church in LA after Ram Dass had come back from India and it was lovely and there were robes and beads and flowers and it was just fun. They were passing out this thing that says, “If you want a copy of this book we’re gonna publish, fill out one of these cards.” We were going, “Oh, these hippies, I’m not gonna bother filling out the card, ’cause it will never happen.” But it did and it’s still in publication.
Stanislav Grof
As the glorious phase was being dampened by the criminalization and all, there came from Czechoslovakia, the Stanislav Grof, where Stanislav Grof had been, when I was graduating from gymnasium (Gymnasium is like high school/junior college). The summer after gymnasium Stan wanted to become a cartoonist, he liked to draw cartoons. He was headed for the Saint Animation School. He had put in his application because you go right from gymnasium to university or professional school. Then a friend of his came by who had found a copy of Freud’s Interpretation of Dreams. (Freud was forbidden literature in community culture, Czechoslovakia, behind the iron curtain at the point). The friend was very excited about the book, you know try to get a college kid today to read the Interpretation of Dreams, it’s impossible, but tell them they can’t and boy!
Stan picked up the excitement and begged to borrow the book and he said he stayed up all night reading it. Stan then withdrew his application to film school and put in one to become to medical school. He wanted to become a psychiatrist and a psychoanalyst, which he did. Stan trained underground, doing his residence at Charles Hospital in Prague where they were working with the Sandoz Corporation in the development of some of the new major tranquilizers (Mellaril is what they were working with). Stan said, “You know when you work on a pharmaceutical company they’re always sending you stuff,” and they sent something to the program he was, and there appeared a box of ampoules of LSD from Sandoz Laboratories. They started a research program that was totally the opposite of what Tim Leary’s operation was. The communist country, people lay things close to their chest – amazing research. Curing, curing! It was not suppressive like most of the psychotropics, the tranquilizer drugs. They cured the people of profound depression.
In his book, (now called, LSD: Door to the Numinous, It was called, Realms of the Human Unconscious originally), Stan shares a story of a fellow who was severely catatonically depressed for a long time was given LSD. Their practice was to give a small dose of LSD at first, but he didn’t get anything from it so they had increased the dose and kept increasing it. They had got this guy up to 3500 micrograms before they got the first reaction. The guy got up out of his room, went to the kitchen, made a bologna sandwich, and then went to the day room and played chess.
So, Stan got out of Czechoslovakia to this country (USA). Stan said he came out with two suitcases, which contained his notes and two shirts. He then fortuitously hooked up with a man named, Walter Pahnke, who had Timothy Leary in his still relatively stable phase as a dissertation advisor and engaged the famous Good Friday experiment. Walter Pahnke was a physician who had taken a sabbatical to go to divinity school, and then went back to Johns Hopkins and began working with cancer patients on whom the oncologists had given up because they were beyond any help. They were in pain, they were in despair, they were scared, and they were using LSD with these patients. All the videotapes have gone, the last little bits of videotape burned when Stans house burned down some years ago.
Most astounding videotape is a guy who was a stevedore on the docks of Baltimore, in his 60’s, metastasized melanoma, they couldn’t give him anything orally and they had to inject him with dipropyltryptamine. Stan is sitting for him and in the course of this session, this man goes from a sort of Neanderthal with like maybe a vocabulary of 600 words, half of which are profanities, but mostly grunts. His family had abandoned him and in the course of this session he is transformed and he’s lecturing the great doctor Stanislav Grof about the “great recycling yard in the sky.” I cried. I’ve been through throat cancer myself. I’m with people who are cancer survivors and who are still facing terror and with 35, 40 years we could have been making it better. But we’re getting there, finally. I never thought it would happen.
Here’s Stan with Christina, when they were young and in love. They always were in love. There’s Stan with Albert Hoffman. He and Stan were good buddies.
The John Hopkins research fell apart when LSD became criminalized. Michael Murphy and Stan fortuitously hooked up and Murphy invited Stan to Esalen as scholar-in-residence. After a few years Stan needed to produce an income for Esalen, so he put together the technique called, “Holotropic Breathwork.” When I was telling Stan for the second time, the reason I decided on holotropic breathwork training was that I had an experience with holotropic breathwork that was identical with the most powerful experiences I’ve ever had with LSD. Stan said, “That’s what convinced me too.” It’s not like taking a pill and you don’t have any choice, ’cause you gotta work at it, that’s why it’s called breath work – but you can get to the same place.
Creativity
Rick Doblin was part of the first Holotropic Breathwork training. There were two parallel groups of trainees of Holotropic Breathwork in the mid-80’s. Rick Doblin was in one of them. Rick got it that Timothy Leary wasn’t the way to go. The way to go was to start, get the credentials, go slowly, and slowly, and slowly. (It’s effective). Through the Holotropic Breathwork training, it’s brought people together that have an interest that was disappointed as the 60’s began to fade. A fellow named Michael Mithoefer, who became the lead researcher for MDMA. So, the Holotropic Breathwork stuff really has been the leverage that’s kept things going, where we actually have hope now that we’re going get this (psychedelics becoming legal as medicine).
I was saying to Stan, “Isn’t this great that Michael’s doing the MDMA research.” And Stan says, “Yeah, but you know, that’s all been done, it’s all been written up before. It’s all there. It’s just been forgotten. The real potential is creativity.”
And indeed, from counterculture to cyberculture. Rick has been working in the psychological realm and some of the other people that came out of the 60’s, Steve Jobs, among them. The future looks bright to me. And I’m sure happy I’ve lived long enough to see it.
Are you looking for a basic introduction to psychedelics and harm reduction? Check out this mini-course!
In this episode, Joe interviews Philip Wolf founder of Cultivating Spirits, a cannabis pairing company. The talk includes topics on Terpenes, Social Consumption and the Cannabis experience industry.
3 Key Points:
Terpenes are the component in cannabis that produce the aroma and ‘mood’ you will be in after smoking.
As more and more places legalize cannabis, the market opportunity for combining food and cannabis grows.
Cultivating Spirits is a cannabis experience and tour company that offers small-batch cannabis, fine wines, and locally sourced gourmet meals. They are a leader in cannabis-infused experiences.
Philip has been in the legal industry of cannabis in Colorado for 9 years
Cultivating Spirits started in Breckenridge, Colorado in 2014 after legalization
He went to a wine experience event and had an epiphany of bringing the cannabis experience to the ‘soccer mom’
He walked away from equity in multiple companies because he believed in it
Cultivating Spirits is the first company to offer a cannabis pairings experience
After learning about terpenes he learned about pairing foods with attributes of cannabis
Terpenes
There are 3 components in cannabis that give you certain feelings
THC gets you high, gives a euphoric feeling
Flavonoids
Terpenes produce the aroma of cannabis and it determines the ‘mood’ you will be in after smoking
Terpenes are produced in all plants and produce, they attract pollinators and help fight disease within the plant
THC-A is non-activated THC, meaning it needs a flame or heat to activate it
Michael Pollan’s book – Botany of Desire
At the base genetic level, our goal is to reproduce and expand
“Are we the workers for this plant?” – Philip Wolf
People’s Reactions
They are loving it!
The average age for a person who attends Cultivating Spirits is 45
Cultivating Spirits focuses on parties and events
Old folks are some of the best clientele, they don’t have jobs and they are done with all of the hassles of making a family and working hard for their job, etc.
Microserving
Microserving is one hit
Holding cannabis in longer doesn’t get you higher, it’s about the surface area of your lungs
So if you expand your lungs very lightly, you will get less high than if you would if you fully expand your lungs when taking a hit
Expansion
Cultivating Spirits operates all over Colorado
They are working to expand to Las Vegas
They also opened up Cannabition
They are taking this business to other places with good heart
Cannabis Nightclubs and Social Consumption Lounges
Cannabis isn’t the reason for the decline in alcohol sales, but the desire for new experiences
Philip believes it will happen first through coffee shops
Everyone needs food, so it’s a great market to integrate into
“I use cannabis like I use a cup of coffee, I use it, but I don’t use it all day” – Philip Wolf
Cannabis… Psychedelic?
There is a psychoactive part to cannabis
Philip says he uses cannabis to deepen his meditation and yoga practice
He is a Certified Yoga Teacher
Although he is certified to teach, he did it for himself and to learn tools he can use during his whole life
Cannabis is a mirror – it’s what’s inside already but getting amplified
First Dinner Approved by Municipality
The opening of X-games in Aspen, CO in 2015
5 courses, 5 wines, 5 strains of cannabis
A DJ from Thievery Corporation deriving beats from where the food dishes come from
Check out this FREE online course, “Introduction to Psychedelics”
About Philip Wolf
Philip Wolf is one of the world’s first pot sommeliers, an expert and pioneer in the field. In 2014, he opened Cultivating Spirits with a mission to show mainstream America how cannabis should be treated. Setting tables with forks, wine, and pipes, Wolf’s pairings are grounded in the science of interpening, which the institute calls “a method used to identify and understand cannabis variety [by] interpreting … terpenes and flower structure.” Wolf can sniff a bud, identify the strain and terpenes, and interpret both the flavor profile and high. The protocol for his dinner with bud pairings is puff, eat, drink.
James Oroc is the Author of Tryptamine Palace and the New Psychedelic Revolution.
Show topics include Burning Man, visionary art, drug war, and politics around the 5-MEO-DMT experience.
3 Key Points:
James Oroc is cautious about the medicalization of psychedelics. He believes psychedelics do not necessarily heal sick people, but instead bring a new perspective to healthy users.
The 5-MEO-DMT experience is not like the typical psychedelic experience, not everyone should do it, and there are some serious negative side effects that could last for years if not integrated properly.
The Bufo Alvarius desert toad is at risk. With climate change and the demand for using them for their 5-MEO-DMT, there is a lot of pressure on their survival as a species.
James has written a few psychedelic books, and is kind of a psychedelic icon
His interests are in noveling and extreme sports journalism
He wrote a book for Burning man, and gave away 500 copies at the festival
He is a world-class paragliding competitor
He believes always being in nature is important
In the late 80’s the psychedelic culture had crashed, except for the mountain towns, which is where the psychedelic community ended up
Joe lives in the Rockies, and was hanging out in Aspen and ran into an old hippie deadhead who talked about skiing on mescaline, when everyone would typically ski on acid
In James new book he goes into psychedelics and extreme sports, about using a dose smaller than the psychedelic dose but larger than a microdose
Joe references a movie, Valley Uprising, where most of the climbers would hang out on the side of a mountain face, party all night, drop a bunch of acid and then sprint to the top
James’ Interest in Psychedelics
James says that 5-MEO-DMT converted him from to being a scientific, rationalist, atheist to agnostic, being merged and one with the god source, through the classic mystical experience
He says it took him multiple years to figure out how a 40-minute trip experience shifted his entire perspective for the rest of his life
That’s why he wrote his Burning Man book, as a way to help others relate to the experience and make their own sense of it
Joe says James Book is far more fascinating than Michael Pollan’s Book, especially for people that have been in the psychedelic space for a while
Michael Pollan states in his book that LSD was given to Tim Leary by Alfred Hubbard, but James says that’s not true, he says that a man by the name of Michael Hollingsworth gave LSD to Leary, after coming to America with a jar of mayonnaise full of LSD
James says its amusing for Pollan to form stories to fit his own narrative
He says Pollan has talked about using psychedelics only four times, and that he doesn’t like the psychedelic culture and by using them we will become more depressed
James thinks depression is a result of the paradigm that we are in
“I don’t like the idea of psychedelics being used as bandaids to help people except for the current paradigm, I like the idea of psychedelics being dynamite, to help bring the next paradigm shift” – James
Smart people are depressed because they are realizing we are screwing this planet up, and we may not have that much time left on it
He called it ‘extinction denial’ in his last book, and after writing his last book in 2009, its gotten exponentially worse
Joe asks James why he thinks people are denying the extinction narrative
James replies saying people feel like they can’t do anything about it, they worry about paycheck to paycheck, and get caught up in all the small distractions of life. He says no wonder people are depressed
Psychedelics aren’t a Medicine
James thinks the only reason they didn’t take hold as medicines in the 60’s is because they were difficult to use, and didn’t fit in the medical model
“The problem with medicalization is it puts psychedelics in one box, I’m more interested in giving psychedelics to healthy people than sick people”
They don’t fall under the true classification of medicines
James thinks they should be called therapy, instead of medicine
He understands the interest of why people want to use them as medicines, but that shouldn’t be the only way they are used
Joe adds that the medicalization doesn’t mean rescheduling – via drug policy alliance
James says that last year alone had the most arrests for cannabis than any other year, even as more states are ‘legalizing’
Joe mentions a comment from Brian Normand who runs Psymposia, “Is cannabis really legal, if you can only have 6 plants? It’s just heightened regulation.”
James thinks that keeping cannabis illegal in the south is the main tool for racial profiling, it’s the gateway drug to prison
Brooklyn wants to release 20,000 cannabis offenders
America
James thinks living in America is like living in the belly of the beast
There are so many forces at work in the US, James thinks the best thing for the world would be for it to break up in a few smaller countries, although it’s probably not going to happen
“It’s not where you want to be, its where they’ll have ya” – James
The data that John Hopkins comes up with is what we need to fight the cognitive liberty we should have to take psychedelics
Joe says Stan Grof became uninterested in the research of psychedelics and became more interested in visionary art
Creativity is what could help us survive
“Art could be the next religion” – Alex Grey
Reemergence of Spirit
James thinks we are in an interesting time in history, all of the models and structures are collapsing, we are getting to an individualized view of everything.
We have the right to create our own spirituality and religion. If we all go find what we find and then come together in clusters of like findings, that is a way for our spirituality to grow
Daniel Pinchbeck mentions cloistering up in small subculture communities focused on individual sub-aspects of what interest you
The reemergence of spirit is important and can happen with the democratization of psychedelics
Psychedelics play a role in inner reality and outer reality
“Psychedelic perspective is the worldview that we take on as a psychedelic user, and its the perspective that the planet needs to survive. Whether as a society that we can shift to that perspective quick enough, is the issue. But the tools are in hand.” – James
Burning Man
James tells a story of this wealthy CEO who attends Burning Man, and gets back and realizes he’s a rich asshole and starts contemplating how he can make his company better for the world and be better to his employees
Burning Man has a lot of potentials like psychedelics do, but it was easier back then Burning Man has blown up and isn’t what it used to be
These highly impactful experiences are more influential when they are small
Boom, a festival in Portugal is a free environment because everything is legal, there is no paranoia
Burning Man used to be free, but because things are still illegal, it has more of a defensive posture now
There are so many resources, police, undercovers, put into Burning Man for how little of crime that happens
John Gillmore – had the largest civil suit against the US govt. for phone tapping
If you have an intense psychedelic experience, take some time and integrate it
“The first place you go after a major psychedelic experience is the library”
James says 5-MEO-DMT was the greatest intellectual adventure of his life
He couldn’t grasp the concept of quantum physics, after 5-MEO-DMT it was one of the only things that made sense
Alexander Shulgin – plus four
James had a paradigm shift after the first time smoking 5-MEO-DMT
He says 5-MEO-DMT is extremely powerful, he doesn’t do it as much anymore, because he appreciates how powerful it is
He also believes that it’s wrong for ‘shamans’ to take the drug while facilitating
LSD is considered not powerful because its been dialed down
People don’t take the same dose that people used to in the 70’s
Every community should have its own psychonaut
James thinks people should not start with 5-MEO-DMT, but start with something less intense like mushrooms and a walk in the woods
Joe did a lot of holotropic breathwork before taking psychedelics
So many people go right to ayahuasca because they are out of the psychedelic culture and are being advertised to
James is annoyed with people calling drugs medicine out of context, like at a festival
He thinks toad is a sacrament, or therapy, not medicine. It hasn’t healed anybody
He believes that the ‘toad shaman’ culture will be eliminated once chemists start to synthesize 5-MEO-DMT
The toads are coming from an overly populated desert, and with climate change, there is a lot of pressure on these species survival
Final Thoughts
James suggestions
The 5-MEO-DMT experience is unique, it’s not like the typical psychedelic experience, not everyone should do it, and there are some serious negative side effects that could last for years if not integrated properly
Start with classic psychedelics like LSD or mushrooms, and go for a walk outside
Stan Grof’s house/library burnt down, Terence McKenna lost two libraries, and Jonathan Ott’s library burnt down. Decades of research burnt down
Check out this our online course, “Introduction to Psychedelics”
Journalist, photographer, and artist James Oroc was born in the small South Pacific nation of Aotearoa. Since 1998 he has been pursuing and reporting on the cutting edge of extreme sports in more than 40 countries around the globe, his work appearing in magazines, films, and on MTV Sports. He has been a member of the Burning Man community since 1999, and he is also involved in the documentation and advancement of “Alternative Culture.”
Tom Hatsis is an intellectual, occultist, psychedelic user and advocate from Portland, Oregon. In the show, Joe and Tom talk about his new book about microdosing. Joe prepares listeners about the controversial topic, magick, which is highly discussed in the show. Witch craft, western shamanism, old religion and magick are all mentioned during the conversation. Tom is a coordinator for Sanctum Psychedelica, a psychedelic club in Portland.
3 Key Points:
Tom’s book Microdosing Magic is a book of templates for people to fill in the blank according to what works for them
Magic isn’t the ‘hocus pocus’ witchy stuff that people always assume, it’s actually mind hacking, reframing and neurogenesis, that every individual is born with the ability to tap into
Magic is a great way to create containers to frame our psychedelic experiences
Tom’s Book – Microdosing Magic: A Psychedelic Spellbook
Tom thinks having a childlike wonder and being curious helped him write his book
He has written 4 books, 3 have been in psychedelic topics
Tom’s background – a part of the Roller derby background since 2005
His first book was called The Roller Derby: A Sensation that caused a Book, the Confessions of a Roller Derby Mascot.
Then he got into psychedelic history and wrote The Witch’s Ointment, Psychedelic Mystery Traditions and his newest book, Microdosing Magic.
Portland is a great place for the psychedelic renaissance
Microdosing Magic
Tom said we should be using psychedelics in a magical way
Joe agrees saying when using psychedelics we should be flexible philosophically
Joe mentions the Robert Anton Wilson reality tunnels
We all have a B.S. (Belief System) and then reality tunnels are the marxist sunglasses and the capitalist sunglasses and feminist sunglasses, instead of having 40 glasses to see behind bias, we all have our own pair of shades
Microdosing is a tool that helps people become childlike, more genius
Magic
Microdosing Magic is a book of templates for people to fill in the blank to what works with them
Tom never tells people what to do with psychedelics, he is offering insight and techniques
Using his own techniques, him and his partner are about to win a guinness world record
“If microdosing is like a healthy diet and magic is like exercise, that’s great. But what happens when you put healthy diet with exercise? You have something far more powerful than those two things could have been by themselves. That’s how microdosing magic works.”
Magic = mind hacking, re-framing and neurogenesis
The Four Gifts
Tom talks about ‘The Four Gifts’ in his book
They make up the beginning of his personal magical system that he has cultivated over his lifetime
Carl Sagan quote, “The cosmos are within us, we are a way for the universe to know itself”
Tom agrees strongly with that saying, he thinks we are microdoses of that cosmic magic and from it, we’ve received 3 immaterial gifts, Intellect, Emotion and Will, however, due to our evolution in physical bodies, we’ve inherited a fourth gift, action
The magical system is about aligning your intellect, emotion and will, so that when we take action, we are acting in pure magic
Magic is super powerful, not something that happens at Disney World. It’s a very real thing that every individual is born with the ability to tap into
Orenda – the magic that you are born with
Microdosing Magic is Tom’s small contribution to bettering the world
Joe says there are so many people that practice subtle magic and don’t even know it; in catholic religion, in yoga practice
Tom has a friend who ‘doesn’t believe in magic’, who is a hardcore material reductionist, who has a ‘lucky hat’
Tom – “This isn’t for people with claws and fangs, magic is for anybody who recognizes their own power and wants to harness their power to make their lives and the world around them a better place”
Neurogenesis, better firing, and re-framing happens in a person’s brain after consuming Psilocybin, Lions Mane and Reishi
Tom says he was addicted to coffee, and after using Microdosing Magic, he hasn’t needed a cup of coffee on 8 months because of his new neural pathways
Joe jokes about overdosing on coffee for a few months on his coffee addiction
Tom jokes back that he’d just drink it out of the pot
Creative Genius
Dr. George Land study – 98% of 5 year old scored in the creative genius category in the same test that 32 year-olds only scored 2%
The modern education system robs us of our creative genius that we all had when we were kids, but at no fault to the teachers. The education system, buys these education models that just don’t work
Tom – “You have to use the internet wisely and not foolishly, to educate yourself and not de-educate yourself”
The Book Tour
Joe asks about the most interesting questions Tom has received on tour
Most people ask about dose sizes and safety questions
Tom explains that he gets nervous about certain questions because he isn’t a medical professional or a therapist
Tom “If you wouldn’t take a psychedelic dose, don’t start microdosing”
Microdosing
Tom has been microdosing on and off for over 20 years
“We didn’t call it microdosing, we called it being broke, we could only afford 1/8th of acid, so we split it up. We felt way more energy, I started writing way more songs, I couldn’t put my guitar down. It sparks that creativity”
Joe says it’s never been a better time for the psychedelic and microdosing renaissance
Cannabis is now legal in 13 states
FDA just approved mushrooms for PTSD in Canada
MDMA is in phase 3 testing
Tom says people in Silicon Valley, and believes people in Congress and DC are microdosing, they just can’t talk about it
He mentions a talk he just did in Salem, a very conservative place, and no one had any questions. And then after the talk, everybody came up to him privately and asked him their questions
Tim Leary made a joke on Liberals not wanting to ‘risk face’
Joe comments on Tom’s book saying it was playful, inspiring, and not threatening like some magic can be
Tom says we don’t have villages for support anymore, we have community which has replaced that
Sanctum Psychedelia’s main focus is community building
Tom uses an example of people going to Peru, taking ayahuasca, and because they don’t have that mystical framework, they come back to their regular lives and say “now what”? That’s why integration and community are so important
Tom says he’d love to see ayahuasca and ibogaine clinics with all the great results people have received from their heroine or cigarette addictions
Tom’s favorite presentation ever was Mark Haden’s blueprint on the future of psychedelics psychotherapy Mark Haden’s Presentation on Psycehdelics Mark Haden Psychedelic Reneissance
Cannabis and the War on Drugs
Tom likes to buy his cannabis directly from his farmer, he prefers to not have the government interfere
He says Gene Simmons from KISS has been so anti cannabis and now all of a sudden is promoting cannabis
Joe brings in the drug war issue, or the issue of people being put in jail for nonviolent crimes (cannabis)
Tom brings in another issue, saying that if a person is charged for drugs at one point in time that later becomes legal, they aren’t allowed freedom because of the fact that they did the crime during the time where it was illegal
Racism and the war on drugs really bothers Tom
Amanita and the True History of Christian Psychedelic History
Tom – “Psychedelics are an excellent way to change your mind and yourself”
Magic is a great way to create containers to frame difficult psychedelic experiences. It’s about putting new frames on your reality
Check out this FREE online course, “Introduction to Psychedelics”
About Tom
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Thomas Hatsis is an author, lecturer, and historian of witchcraft, magic, Western religions, contemporary psychedelia, entheogens, and medieval pharmacopeia. In his spare time he visits rare archives, slings elixirs, and coaches roller derby.
Bluebird Botanicals is leading the industry in third-party testing and Lab results, green initiatives and a stand on hemp policy.
CBD helps cushion the psychoactive impact of THC on CB1 receptors, making for a less intense ‘high’.
Lex has a lot of hope for the 2018 Farm Bill, and believes hemp has widespread uses that will open many market opportunities in the future.
Intro
Joe interviews Lex Pelger, Science Director of Bluebird Botanicals, a Colorado-based company. They talk about CBD and the issues with the FDA talking about health benefits. The use cases of hemp and drug war are discussed.
Who is Lex Pelger?
He is a Science Director of Bluebird Botanicals. Lex moves from New York to Colorado. He did a psychedelic storytelling open mic tour (Blue Dot tour) across the USA and it culminated at the MAPS Psychedelic Science Conference. Moved from the hustle of New York to Colorado to have his baby.
The Cannabinoid
Lex gets excited the more he learns about how intricate the endocannabinoid system is to humans and all mammals
Bluebird Botanicals doesn’t make any medical claims
CDB supports health and homeostasis
The cannabinoid system was discovered in the body only 25 years ago
Opium and Cannabis were the two oldest plants used in the body
There isn’t anyone connection for cannabis, because there are so many receptors in the human body
There is a ton of research happening on cannabinoids
Lex thinks the research ban on phytocannabinoids is unfortunate
Cannabis and cannabinoids are the most studied drugs in the US
CBD functions as a homeostasis molecule
Anandamide was the first endogenous cannabinoid discovered in the human brain in 1991 by a team led by Raphael Mechoulam in Israel
Raphael Mechoulam discovered the final structure of THC in 1963
CB1 Receptor in the brain was discovered in 1991 also
CB1 Receptor
If the CB1 receptors are blocked in a human or animal, they won’t get ‘high’ on weed
The presence of CBD doesn’t allow THC to fully bind to the CB1 receptor, so when CBD is present in THC, you won’t get quite as high
Lex thinks it’s unfortunate that because weed has been in prohibition, it has been bred so hard to only have THC
He thinks all weed should have a little bit of CBD to cushion the psychoactive nature of THC
The Endocannabinoid System
Joe says there is no profile to test the endocannabinoid system to know if a person is deficient or not, that he knows of
Lex says if you get your genetic results from a company like 23 and me, it will tell you about your cannabinoid alleles
A bad trip to a young brain can damage it forever
The activists that annoy Lex are ones that refuse the obvious negatives
Weed should not be given to all children
The ‘Right to Fly’ Jonathan Thompson – Psychedelic Parenting Blog and Podcast
How to create a community on psychedelics Noah Potter – Psychedelic Law Blog
An open-source thought experiment in psychedelic law and policy
“This plant is tied down by so many regulations” – Lex
In the state of Colorado, you can’t make new genetics
Lousy laws made it hard to diversify the cannabis plant
Lex believes Aldous Huxley’s book The Island is the best blueprint for what a sane integration of psychedelics and psychoactive might look like.
Lex says people taking mushrooms in the woods together is so special, simply because a group of people is spending 6-8 hours with nature and with each other.
Bluebird Botanicals
Many different products – isolates, oils, vape juice, and topicals will be back soon
Independent Lab Verification
Leading the industry with third-party lab results
Transparent about ingredients, NO pesticides used!
Paired with Eurofins – world’s biggest testing lab
Bluebird partners with the farmers, packaging partners, etc to be green and more eco-friendly always
CEO Brandon hears about a new point of quality to be added, he goes for it
Passed 99% inspection quality, CGMP
Lex thinks its so nice to work for a company that focuses on giving back to the customers, focusing on employees, quality, the planet, and just giving back
CBD Drug Law Changes in California
The regulations restrict being able to add CBD to food, which goes is against the 2014 Federal Farm Bill
Bluebird is on the board for the US Hemp Roundtable – Hemp Policy
Jonathan Miller – Lawyer of the group and writer to address misinterpretation of the law
“It’s foolish to have the 1950’s 1960’s mindset of cannabis” – Joe
Marijuana vs Hemp
Both are cannabis plants
Cannabis is the species, THC is more than .3% THC, Hemp is less than .3% THC
“If a state inspector comes in and tests 6 samples and the results come up as .4% or .5%, they make you burn it. They don’t burn it for you, you have to burn it yourself while you watch.” – Lex
Cannabis is tricky to grow for commercial use
It takes 3 generations for the plant to get used to the environment
“Thank you, farmers, for being farmers” – Joe
2018 Farm Bill
Mitch McConnell majority leader of the Senate, is pushing this because he comes from Kentucky, the Hemp state. The Senate version of the Farm Bill is correct, the House version has none of the correct language in it. McConnell and the pro-hemp committee will hash out the differences between the two bills. This Bill expands on all of the rights so it makes it look more enticing and safe for big businesses like Whole Foods and Banks. This bill is going to open up many markets.
Hemp as an Industrial Product
“What’s really cool about hemp is how widespread the uses are” – Lex
The Hemperor, Jack Herer discovered all of the uses for the hemp plant
Oil and plastic did win, hemp did not win as a top 10 commodity
It’s a hard plant to work within the processing stage
Thomas Jefferson stopped growing hemp because the retting stage was too hard on his slaves
Hemp is not going to change all the markets it’s been said it will transform
Lex says hempcrete is fascinating. Using hemp as lubricants, bath bombs, and just the seeds are fascinating uses
The Russians and the English fought in a war over access to hemp
Hemp is a rope that doesn’t get destroyed by saltwater, fueled the world’s Navy
Fiber is so important, and hemp as a fiber was widespread
Hemp seeds are a perfect mix of essential fatty acids
Hemp seed made pigeons breed more
Joe says there was a huge tradition of people eating pigeons
Agriculture is so bad for topsoil, hemp can help repair our lands for us to keep surviving
Hemp is a holy material in Korea
Joseph Needham layed out all of China’s inventions and explained that the founders of Daoism had a cannabis-induced ‘dream’ and envisioned the first Daoist school where Yin and Yang came from
Lex’s job as a Science Director for Bluebird
Lex does a lot of education around CBD, Cannabinoid science conferences
His passion for cannabis stems from his grandma’s medical condition
He wanted to find a way to describe the cannabinoid system for elders to understand
Lex is thankful for groups like Erowid, who sit down and interview our elders
Lex tells a story about a man who took LSD in the woods, and fell to the ground and felt one with the trees, felt himself rooting down, and felt complete. He never forgot that feeling
Lex thinks that a person should be stable before embarking on a psychedelic journey
“Huxley says that therapists are attracted to psychedelics because of their own dark icebergs” – Lex. He thinks that therapists should be A gatekeeper, not THE gatekeeper
Joe has been trying to get in touch with Dana Beal who popularized ibogaine
“Dana Beal was an old-time, cowboy pot smuggler to fund yippie political activism, outreach, and political activism, so he could make the way that he made money, illegal” – Lex He used the system against itself
Cannabis can cause catalepsy in people – which makes one ‘blackout’
90% of cointel pros were against the Black Panthers
Hoover feared them because they were black and he was racist
They were extremely effective
Lex explains that the war on cannabis has a racist framework, Nixon said “Because black people use cocaine and hippies use cannabis, we can use it against them”
Lex goes on to talk about the history of the CIA, which puts its money into drug trade because it’s untraceable, they protect the drug lords to use it for their own financial benefit
He says the CIA and DEA are inefficient bureaucracies
“Our belief at Bluebird, is we have to end the war on drugs. It’s not a war on drugs, it’s a war on people. The war on drugs is incredibly effective at doing what it was designed to do, and that was to hold, certain people groups down”
Joe comments saying that there are babies being born and being brought into this world. He appreciates Bluebird for having proper business practice
Final Thoughts
Lex finished his Moby Dick Pot books about the endocannabinoid system and the war on drugs He says he based them on Moby Dick because it was the only thing large enough to fit the entire history of cannabis and war on drugs
He does the Greener Grass Podcast for Bluebird which includes topics on cannabis and green initiatives.
The consumption of 5-MeO-DMT by inhaling bufotoxins from the Colorado River toad (lat. Incilius Alvarius), also known as “Bufo Alvarius”, “El Sapo/Sapito”, “Bufo”, and “Toad”, has become increasingly popular in a variety of underground ceremonial settings in recent years. Furthermore, due to the realization of the potential 5-MeO-DMT holds for therapy it has also become a new interest in psychedelic research.
When I started psychedelic research for my dissertation at Maastricht University in fall 2017, there was no research addressing the subjective effects from inhalation of bufotoxins in humans. Thus, I brought it upon myself to investigate this further as the consumption of the so-called “toad-medicine” was booming worldwide.
The primary aim of the study was to investigate whether the bufotoxins from the toad, which is known to contain significant amounts of 5-MeO-DMT, as well as other compounds, produces long-lasting changes on affect and thinking style. The second objective was to assess whether the acute and long-term effects of the bufotoxins depend on the degree of ego dissolution and altered states of consciousness that was experienced during the ceremony. The preliminary evidence of this study was presented at the Beyond Psychedelics conference in Prague in June, and the recording of this presentation is now circling around on the web.
Even though the study results are very interesting and important to highlight due to the consumption of the “toad-medicine” worldwide, I think it is of equal importance, if not more, to shed light on another side of the story. A side of the story that for once does not focus on humans.
This article aims to share information, increase awareness, and stimulate reflection about how the consumption of bufotoxins affect the toad.
5-methoxydimethyltryptamine (5-MeO-DMT) is a potent, fast-acting, natural psychoactive indolealkymine substance, which acts as a serotonin (5-HT-1-A/5-HT-2A) receptor agonist (Shen, Jiang et al. 2010, Szabo, Kovacs et al. 2014). 5-MeO-DMT was initially isolated from the bark of Dictyoloma incanescens (Pachter 1959), and has also been found in the milky-white secretion that protects the Incilius Alvarius toad against predators (Weil and Davis 1994).
This toad, also known as Bufo Alvarius, has become well-known worldwide as a “5-MeO-DMT-making-machine”. Its secretion, when inhaled through vaporization, has proven to be powerfully psychoactive within 15 seconds, causing an experience of unity reported by participants in underground ceremonies in the most repeated soundbite “we are all one” (Weil and Davis 1994).
The presence of 5-MeO-DMT in the secretion is not the only substance that makes the toad so interesting. In fact, it is also the only species whose skin contains 5-methoxyindolealkylamines as well as 5-hydroxyindole-O-methyl transferase activity (Erspamer, Vitali et al. 1967). This enzyme, among other reactions, converts bufotenine (5-OH-DMT) to the potent hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) (Weil and Davis 1994).
That being said, bufotoxins are the name of a collection of compounds which can be found on the toad’s skin, and in the two glands behind the eyes called the parotid glands (Tyler 1976). Several types of toxic and non-toxic substances can be found in the bufotoxins and they include the following; cardioactive agents such as for example bufagins (bufandienolides), catecholamines such as epinephrine and norepinephrine, indolealkylamines such as bufothionine, serotonin, cinobufotenine, bufotenine and dehydrobufotenine, and finally noncardiac sterols, which are non-toxic, such as cholesterol, provitamin D, gamma sitosteral and ergosterol (Chen and Kovaříková 1967). Moreover, as illustrated in the work for Erspamer and colleagues (1967) using paper chromatography, the bufotoxins include not only 5-MeO-DMT but also many other compounds. As previously mentioned, these compounds protect the toad from predators, and can, for this reason, have fatal consequences as demonstrated by reports of animals that have died after biting toads.
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Although these bufotoxins are a natural defense mechanism of the toad, humans have found a way of using them for a different purpose. At the present time, a number of people are smoking bufotoxins at underground ceremonies. Moreover, many also make use of 5-MeO-DMT from plant extract (i.e. yopo) or from a synthetic origin. A recent survey by Johns Hopkins demonstrates that use of 5-MeO-DMT, from either toad, plant extract or synthetic origin, is used infrequently and primarily for spiritual exploration (Davis, Barsuglia et al. 2018). Anecdotal, and empirical evidence demonstrates that people also use 5-MeO-DMT for treating psychiatric conditions such as depression, anxiety, posttraumatic stress disorder and substance abuse (Psychedelic Times, 2016). The resulting subjective effects appear to be due to the compounds ability to induce mystical experiences which have been demonstrated to have lasting beneficial effects (Garcia-Romeu, R Griffiths et al. 2014).
To be able to inhale the bufotoxins one would have to “milk the toad.” It is worth noting that the toads hibernate for most of the year, and generally appear just before summer showers, and congregate when the rains begin for reproduction (Fouquette Jr 1970). This is the time when they can be found and milked. The pamphlet titled “Bufo Alvarius, the Psychedelic Toad of the Sonoran Desert” outlines detailed instructions for collecting and drying the venom;
“You hold it [wearing gloves] over a flat glass plate or any other smooth, nonporous surface at least 12-inches square, the toad is held in front of the plate, which is fixed in a vertical position. In this manner, “the venom can be collected on the glass plate, free of dirt and liquid released when the toad is handled” (Most 1984).
Moreover, from the article Weil and Davis from 1994:
“One Bufo Alvarius yield 0.25-0.5 gram of dried venom. Since concentrations of 5-MeO-DMT may be as high as 15% one toad may yield 75 mg of an hallucogenic drug that, when smoked, is effective in humans at doses of 3-5 mg. In other words, a single toad produces 15 or more doses of one of the most potent psychoactive drugs found I nature. A matchbox sized container would represent thousands of effective doses.”
With this in mind, it is no wonder that the harvest and consumption of the toad’s bufotoxins have increased.
The harvesting of the toad’s bufotoxins happens not only from the hands of facilitators of ceremonies, or consumers but also from toad-hunters such as the ones filmed in “Hamilton’s Pharmacopeia: The Psychedelic Toad” who after harvesting the bufotoxins sell it (VICELAND 2017). In the video clip, the toad-hunters report that they have collected around 500 grams of bufotoxins over the years. This equals 5,000 doses if one dose is 100 milligrams of bufotoxin, and means that in order for one person to have the experience at least two toads must be milked.
Now how does the harvesting and consumption of bufotoxins impact the toad?
At this point in time (October 2018) the toads are classified as “least concern” on the IUCN Red List of Threatened Species (Hammerson & Santos-Barrera, 2004). Although this may be true, these assessments are from 2004, and is therefore very likely to be outdated. A new assessment about the toad’s population size is highly warranted given the attention the toad has received and the consumption of the toads’ bufotoxins worldwide.
Nevertheless, it is not old news that the amphibian population worldwide is declining. Actually, their global decline was first recognized in the early 1990s (Wake 1991). As of 2010, 32% of the world’s nearly 6600 amphibian species are threatened with extinction, 43% are experiencing declines and for another 22%, there are insufficient data (Stuart, Chanson et al. 2004). This phenomenon represents the Earth’s sixth mass extinction (Wake and Vredenburg 2008). That being said, there is no single cause to the global amphibian decline, rather there may be several contributing factors (Hayes, Falso et al. 2010). As outlined in the paper by Hayes and colleagues, there are three levels of possible factors for the amphibian decline.
The first level involves 1) death (or removal) of individuals and 2) reduced recruitment within a population. (Editors note: recruitment occurs when juvenile organisms survive to be added to a population, by birth or immigration, usually a stage whereby the organisms are settled and able to be detected by an observer. Source – Wikipedia
The second level involves 1) increased disease rate, 2) decrease in nutrition, 3) predation, 4) human exploitation 5) “other mortality”, which represent everything from the death of older individuals, incidental death, to catastrophic events.
Finally, the third level involves 1) atmospheric change, 2) environmental pollutants, 3) habitat loss, 4) invasive species, and finally 5) pathogens. These levels are also suggested to interact with one another.
It is not rocket science that the above-mentioned factors also have an impact on the toad. The increasing demand for the bufotoxins for inhalation has made the toad susceptible to not only ecological disturbance through the invasion of habitat and excessive milking, but also amphibian-trafficking and black-market dynamics. Additionally, according to herpetologist Robert Anthony Villa, the largest toads are most likely to be spotted and collected over smaller toads, and if you remove the biggest toads, you remove the population’s ability to sustain itself as the bigger toads have a lot of eggs (Psychedelic Today 2018). Moreover, based on studies on snakes, we know that 80% of snakes die if you catch them, move them to a different territory and let them go. Similarly, toads have an inner-GPS that they rely on, and if a toad is taken out of their territory for milking, and then set free elsewhere, they are very likely to die because they are either simply lost, could get run over by a car, or eaten by predators. The latter is more likely to successfully happen when the toad has been deprived of their main defense mechanism.
Along with that, Villa reports that the toad is very likely to be impacted negatively by pathogens, such as for example chytridiomycosis, which is exposed to them by people when they are collected for milking and can spread to the rest of the toad population. Additionally, as the surviving toads depend on the genetic variety of other populations to sustain themselves, the toads would inbreed themselves to extinction if there are no other populations to copulate with. Finally, keeping a toad as a pet, or many in large conservations for breeding, is a huge disservice to the toad as they do not do well in captivity, and due to the factors previously stated.
Given the circumstances, it seems to me that the harvesting and consumption of bufotoxins or so-called “toad medicine” is very much the case of the “double effect” principle; with a good act, comes a bad consequence. The aforementioned are all alarming factors that could very well lead toward population decline and so to extinction. This is all startling information that calls for action.
A discontinuation of “toad medicine” in favor of synthetic 5-MeO-DMT use can diminish the current unnecessary and excessive harassment of the Incilius Alvarius species. Switching from using toad bufotoxin to synthetic 5-MeO-DMT is better for many other reasons. First, synthetic 5-MeO-DMT does not contain a cocktail of other compounds and is therefore much safer to use. Likewise, it will be much easier for researchers to re-schedule and legalize a pure substance for medical use than a complex bufotoxin. Second, synthetic 5-MeO-DMT is not any different from “toad-medicine”. In fact, the argument that “toad-medicine” is better than synthetic is a claim that is drawn from personal experience and is not a good enough argument to extend to a generality.
I personally think it is important that we start to reflect upon the implications our actions have on the toads and take action. It is not necessary to wait until the toads are classified as endangered before we act.
My hope and wish for the future is that all of us, be it, consumers, researchers, organizers, or facilitators, will think twice about whether experiencing 5-MeO-DMT at the expense of a species’ continued presence on this planet is worth it. Especially when there is an alternative way which is much safer to use, not any different from the effects of the bufotoxins, and does not contribute to ecocide.
The book “Homo Deus; A Brief History of Tomorrow” highlights several important and interesting topics. One of them is the power human beings have, and how this power can affect the future of the planet. One thing that Harari points out, which seems to be very fitting for this moment, is that humans have the capability to do many things, but that question is not “what we can do?”, but rather; “what should we do?” (Harari 2015).
References
Chen, K. and A. Kovaříková (1967). “Pharmacology and toxicology of toad venom.” Journal of pharmaceutical sciences56(12): 1535-1541.
Davis, A. K., J. P. Barsuglia, R. Lancelotta, R. M. Grant and E. Renn (2018). “The epidemiology of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption.” Journal of Psychopharmacology: 0269881118769063.
Erspamer, V., T. Vitali, M. Roseghini and J. M. Cei (1967). “5-Methoxy-and 5-hydroxyindoles in the skin of Bufo alvarius.” Biochemical pharmacology16(7): 1149-1164.
Fouquette Jr, M. (1970). “Bufo alvarius.” Catalogue of American Amphibians and Reptiles (CAAR).
Garcia-Romeu, A., R. R Griffiths and M. W Johnson (2014). “Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction.” Current drug abuse reviews7(3): 157-164.
Harari (2015). Homo Deus: A Brief History of Tomorrow.
Hayes, T., P. Falso, S. Gallipeau and M. Stice (2010). “The cause of global amphibian declines: a developmental endocrinologist’s perspective.” Journal of Experimental Biology213(6): 921-933.
Most, A. (1984). Bufo alvarius: The psychedelic toad of the Sonoran desert, Venom Press.
Pachter, I. J. Z., D.E.Ribeiro, O. (1959). “Indole alkaloids of acer saccharinum (the Silver Maple), Dictyoloma incanescens, Piptadenia colubrina, and Mimosa hostilis.” J Org Chem24: 1285-1287.
Shen, H. W., X. L. Jiang, J. C. Winter and A. M. Yu (2010). “Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions.” Curr Drug Metab11(8): 659-666.
Stuart, S. N., J. S. Chanson, N. A. Cox, B. E. Young, A. S. Rodrigues, D. L. Fischman and R. W. Waller (2004). “Status and trends of amphibian declines and extinctions worldwide.” Science306(5702): 1783-1786.
Szabo, A., A. Kovacs, E. Frecska and E. Rajnavolgyi (2014). “Psychedelic N, N-dimethyltryptamine and 5-methoxy-N, N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells.” PloS one9(8): e106533.
Wake, D. B. (1991). “Declining amphibian populations.” Science253(5022): 860-861.
Wake, D. B. and V. T. Vredenburg (2008). “Are we in the midst of the sixth mass extinction? A view from the world of amphibians.” Proceedings of the National Academy of Sciences.
Weil, A. T. and W. Davis (1994). “Bufo alvarius: a potent hallucinogen of animal origin.” Journal of ethnopharmacology41(1-2): 1-8.
About the Author
Malin Vedøy Uthaug is a Ph.D. student at the University of Maastricht, Department of Neuropsychology & Psychopharmacology. She has a background in health and social psychology and is currently researching psychedelic (ayahuasca, 5-MeO-DMT, DMT, and mescaline) and yoga-induced improvements of mental health. On the side of being a student and researcher, she is a life coach and public speaker. She started her coaching project titled Love & Gratitude in September 2016 which serves as a platform to spread information related to positive psychology, and transpersonal psychology. Love & Gratitude has also become a way to bring about information about psychedelics and help to destigmatize them. She has since September 2016 delivered talks, webinars and workshops in Belgium, The Netherlands, Czech Republic, Norway, United States of America, and Colombia.
You can find more from Malin on Psychedelics Today here.
Download Joe Moore interviews Brian Pace. He studies Evolutionary Ecology, is a science consultant at The Third Wave, and is the director of the project, Mind Manifest Midwest, and instigator of the “Find the Others” project.
3 Key Points:
Psychedelics are not just illegal, they are also taboo, and Brian’s efforts are aimed to create spaces that make it more comfortable to talk about psychedelics.
Online resources are great, but having local, and real psychedelic societies to create community will help people “come out” and be comfortable talking about their experiences.
Brian’s interest evolved from ecology to psychedelics when he realized the issue of global warming. The top environmental problems are selfishness and greed, and changing people’s minds with psychedelics is a big hope for the planet.
Met Paul Austin of The Third Wave at the Global Ibogaine Therapy Alliance Conference.
The conference was foundational in him becoming outspoken about psychedelics.
Ibogaine – last resort option for people suffering from addiction.
Brian and the team built The Third Wave with the goal to bring the conversation about psychedelics to be more comfortable among the general public.
It has been good about building bridges to invite all types of people to the community, not just white males. It’s important to be inclusive in this space.
Find the Others
Started at Psychedelic Science, to talk about what psychedelic societies are.
Aware Project by Ashley Booth (www.awareproject.org)
Psychedelics are not just illegal, they are also Taboo – Michael Pollan
“Were having a cultural hangover from the upheavals we’ve had in the late 60’s and early 70’s.” – Brian
“We can fight taboos when we can have conversations – about that which was taboo – in the grocery store, in the bar, with our parents. I think that’s definitely what’s needed with psychedelics.” – Brian
Had the first psychedelic society meeting at a bar that included a presentation about plant secondary compounds and human health and ended with storytelling.
20% of Americans over the age of 15 have had some experience with psychedelics, 11% with LSD. (source unsure)
Mitch Gomez from Dance Safe – more than 50% of the population of the U.S has done illegal compounds at age 15 and up. Psychedelics have taken a big chunk of that number.
Cannabis is a great help for football players and traumatic brain injury.
“If psychedelics are ever going to be reintegrated meaningfully in society, we are going to need some kind of mentorship.” – Brian
Timothy Leary – “You’re born with the right to fly”. If you start driving on LSD, you might lose that right.
Find the Others, Mind Manifest Midwest, The Third Wave
A collaborative project that allows people to speak in their own words what they are doing in their psychedelic societies.
Psychedelic Societies are real, local and create community.
MDMA for PTSD will be passed at the Federal level very quickly.
Evolutionary Ecology
Psilocybin – PhD focused on plant secondary compounds.
The mycorrhizae network – “the Earth’s natural internet” – Paul Stamets
Climate change
Consumption – eating meat and driving cars
The top environmental problems are selfishness, greed and apathy. Changing people’s mindsets with psychedelics could be an only hope.
“Given that psychedelics have reliably induced mystical and/or religious experiences in people throughout time and across a variety of contexts, it seems natural that we should start organizing communities that help unpack and contextualize these experiences.” – Brian
The status of our society
Why do we have to work 55 hours a week to barely afford a 2 bedroom apartment?
Guaranteed minimum income – an experiment in other countries.
What does our society look like when it is less stressed?
Timothy Leary
“Who knows what you might learn from taking a chance on conversation with a stranger? Everyone carries a piece of the puzzle. Nobody comes into your life by mere coincidence. Trust your instincts. Do the unexpected. Find the others…”
Helped create the importance of set and setting.
Saw the inside of 36 prisons for possession of marijuana.
Check out this FREE online course, “Introduction to Psychedelics”
About Brian
Brian Pace, M.S. is a scientist by training and psychonaut by inclination. His interest in biology was piqued acutely as a teenager while experimenting with his own neurochemistry. For more than a decade, Brian has worked on agrobiodiversity, food sovereignty, urban cycling, and climate change in the US and Mexico. Brian is the co-founder of Mind Manifest Midwest (facebook.com/mindmanifestmidwest), a Columbus, Ohio based psychedelic society and the instigator of the Find the Others Project (findtheothersproject.org), a global collaboration of the burgeoning psychedelic society movement. Since 2016, he has contributed as a strategist for The Third Wave (thethirdwave.co). At The Ohio State University, he co-created a graduate-level class entitled: Cannabis: Past, present, and future cultivation for fiber, food, and medicine. He spent a year slogging around oil and wastewater pits left by Chevron-Texaco testing mycoremediation techniques in the Ecuadorian Amazon. All pipelines leak. Plant medicine is indigenous technology. Brian completes his Ph.D. in Plant Evolutionary Ecology this semester at OSU.
In this episode of Psychedelics Today, Joe interviews Shane LeMaster, a therapist and host of the new Podcast, Conversations with the Mind. In this discussion, we cover personal journeying, changing behavioral processes, Jiu Jitsu, and where we are headed as a collective consciousness.
3 Key Points:
Psychedelics can be a helpful tool for personal journey work.
Each type of psychedelic works as its own tool. They are all useful in their own context and should not be compared to each other as better or worse.
Shane has used psychedelic therapy to help rewire past imprinted constructs of his mind to learn new behaviors in his Jiu Jitsu practice and his daily life.
“Recently, I’ve been working on softening my hard edges”
Construct – the scared child. Our childhood leaves imprints that effect our behavior as adults.
Hyper-masculinity is a result of repressing past issues.
Are there different messages after a journey in ketamine versus peyote?
Substances produce a different feeling as if there is an “other” or “entity” that sends the messages where with breathwork it’s more of a self realization
Drug chauvanism “my drug is better than your drug”
“Is LSD worse than mushrooms for spiritual development? Or breathwork? We can’t say yes or no definitively.” -Joe
Stan Grof – “why would you do breathwork if you have LSD?”
“There is something special about the group work process in breathwork, that deeper sense of connection is hugely valuable.” -Joe
Some substances are better when done alone in some circumstances, and substances used in a community setting as better for different circumstances. We have a choice in which tool
“You can’t build a house with just a hammer. If LSD is a hammer and ketamine is a saw, you can’t say a hammer is better than a saw, they are both essential.”
Ketamine in Fort Collins, CO
Dr. Scott Shannon
Shane
Therapist, making great changes but small changes, looking to make a greater impact through social work, helping people to better themselves.
Interest in mindfulness, positivity interventions, helping people see their power to fix their own issues
The changing landscape of how we understand consciousness
DMT vape pens
Make it more convenient for the consumer
Democratizes the experience, knocks down barriers to be able to have a profound experience
Podcasts – creating conversation about a shift in consciousness
Elon Musk – our intelligence is heightened through proper use of the cell phone
Stan Grof – technology of the sacred (ex. Breathwork)
Tim Leary – “hedonic engineering” – how to live a maximally more pleasurable life
Positive psychology meets wearable technology – developing the steps to the most enjoyable life
Tim Ferris twitter feed – “Creation is a better means of self expression than possession, it is through creating not possessing that life is revealed.”
“Be a creative force in the universe, it feels so good to create, and bring something to fruition, and share it with everybody, not to possess it.” -Shane
Conversations with the mind – Shane’s podcast
“One mind having a conversation with another mind. Two minds interacting, sharing knowledge, sharing distress, sharing solution, and adding the sum of the two parts coming together, and sharing it with the collective mind.” – Shane on the purpose behind his podcast
Guests on the show
How psychedelics help in jiu jitsu
PhD credential people
PTSD patients
Advice from Stan Grof
30-60 days without alcohol is needed before using Breathwork for therapy when treating alcoholism
Analogy – default brain behavior
like sledding down a hill, we always choose the same route. With psychedelics, it helps us see a new route. You stand up, and for the first time, you look up and take a 360 degree turn and see so many new routes that you have the choice to take.
Analogy used to reprocesses trauma, brings new options to think about the experience differently
Microdosing helps bring out new patterns of behavior to learn new skills
“In wrestling, the last place you want to be is on your back, that’s when you get pinned, that’s when you lose a match. In jiu jitsu, being in your back is a good place to be, because there’s a lot of options from there. So I had to unlearn the fear of being on my back. It’s all about retraining my neural pathways, retraining my thinking.” -Shane
Jiu Jitsu
It’s been said, earning a black belt is as much time and effort as earning a PhD
The transferable skills of Jiu Jitsu can be used in therapy, breathwork and integrating psychedelic experiences. It’s all consciousness work.
Check out this FREE online course, “Introduction to Psychedelics”
About Shane
Shane earned his Bachelor of Arts Degree in Psychology from the University of Colorado in Boulder, CO, completed extensive coursework towards a Master of Arts Degree in Sport & Performance Psychology at the University of Denver, and earned his Master of Arts Degree in Sport & Exercise Psychology from Argosy University.
Shane is nationally certified as a Sport Psychology Consultant and a licensed mental health clinician in the state of Colorado. Having worked in community non-profit mental health since 2008, Shane has gained experience working with the entire spectrum of mental disorders and with all populations and age groups. Shane plans on attending a Ph.D program in Counseling Psychology where his interest in Resiliency, Mental Toughness, and Mindfulness Training Program Development can be explored and further developed.
He is a life-long athlete having competed at various levels in more than a dozen different sports. Because of his passion for warrior cultures of past and present, Shane has been ardently developing his own “Warriorship,” training in various forms of Martial Arts for 25 years. Shane feels that the self-discipline, the philosophy of non-violence, the innumerable mental and physical benefits, and the enjoyment that he gains from the Martial Arts is what helped drive his passion in the field of Psychology.
His personal interest in Eastern Philosophy stems from his adoption of a Buddhist lifestyle and blends well with his training in Western Psychological Science. Clients describe Shane as an out-of-the-box clinician that is easy to get along with, knowledgeable on a variety of topics, credible with lived experience, and as having the ability to make therapy fun and interesting.
For the first time in nearly three decades, novel classes of medication are being offered to those suffering from chronic refractory mental health conditions. Studies have shown that 60% to 70% of people with treatment-resistant depression respond positively to ketamine, and some encouraging results are being found with OCD, PTSD, and alcohol dependence.
Though this discovery has been hailed as a massive boon to those living with persistent mental health concerns, their loved ones, and clinicians alike, it may also behoove us to explore the potential unintended consequence of these effective, fast-acting antidepressants.
Many welcome rapid recovery with relief and gratitude in being able to return to their lives; however, in our work with Ketamine-Assisted Psychotherapy, we have noticed that a small percentage of clients also experience a period of disequilibrium and difficulty in adjusting to these changes.
These reactions can range from over-reliance on older coping styles that no longer match one’s current state, to the distress that comes from the loss of a habituated identity (“I don’t even know who I am anymore, without my old buddy, Depression”). I have come to refer to this response metaphorically as “the therapeutic bends,” as a way to suggest the effects that can occur when we ascend rapidly from great depths. In two decades of clinical work, I have seen a variety of ambivalent-to-negative reactions to the prospect of “getting better.” Psychotherapy generally offers recovery as a gradual process, with adequate time to adjust and be supported; the “instant cure” has been seen as both unattainable and potentially illusory. The advent of these new treatments requires a shift in how we guide people through this work. I would like to discuss here some possible layers where distress can occur, and interventions for both clients and providers to consider at each level.
Confronting Reality: Cognitive-Behavioral Layer
Ketamine infusion pioneer and psychiatrist Dr. Steven Levine has been noting this reaction for some time; in a recent blog post, he encourages providers to set expectations with clients that “even good change is stressful (marriages, moving homes, new jobs, and the birth of children are some of life’s most stressful events).” More dramatically, he describes a process in which one emerges from a depressive episode, then becomes overwhelmed by the herculean tasks ahead:
[W]hen one looks around, one sees with new eyes the surrounding devastation and the casualties from an incapacity to do anything about the growing problems…[this] is akin to a poorly prepared survivor of a nuclear apocalypse stepping out of his bunker into a lonely world of destruction.
Dr. Raquel Bennett, a psychologist and founder of the KRIYA Institute, has also been observing the effects of therapeutic ketamine on one’s sense of self for many years. She echos Dr. Levine’s observations that:
Resistance can come up for some people; they get a little better, and then can get scared, sometimes retreating back into a remission, which is actually more psychological than chemical… People wake up and realize how much time was lost to their illness, how much money was spent, how many relationships ruined, how many opportunities missed… We need to think about how painful it is to just be with that, what this condition has done to one’s life (personal communication, August 12th, 2018).
Additionally, those accustomed to very brief respites from symptoms may have a habitual tendency to throw themselves headlong into intense task completion mode the moment remission begins, in an effort to “get everything that piled up done before the storm hits again.”
FOR PROVIDERS: Dr. Levine writes that “even a ‘magic bullet’ leaves a wound that requires a period of recovery,” and that key components to this recovery are social support and ongoing therapy. Therapy should, in part, focus on “teaching new skills to challenge and combat depressive thoughts, and working towards achieving successes that help rebuild self-esteem.“ Similarly, Dr. Wesley Ryan states that he frames ketamine treatment as something that can provide a catalyst for change, transiently lifting depression, and allowing people to more easily engage in other activities that will protect against relapse. He encourages “regular exercise, healthy eating, socialization, behavioral activation, structure/volunteering/work, work/life balance, addressing activities or relationships that clash with personal values (such as work, for some people), potentially setting better boundaries” (personal communication, August 13, 2018). Providers may want to focus here on slowing the work down so as to not trigger overwhelm, cognitively reframing approaches to task completion, and teaching new ways to manage the demands of life. Psychotherapists may also invite expressions of regret and grief around the sense of lost opportunities as a way to work through these feelings effectively. FOR CLIENTS: As stated above, it is important to not overwhelm yourself at this stage. Trust that you will have the opportunity to make repairs and address life tasks over time, and please access as much support as possible to assist you in this undertaking. This is an excellent time to begin practicing new self-care habits that will ensure longer-term change. Additionally, you may benefit from making space in your life to acknowledge and feel any difficult emotions you may have around what has happened and talking to someone you trust who can listen without judgment. You may want assistance from a therapist, support group, or a good self-help guide in shifting how you think about yourself and your life.
Readjusting Roles: Interpersonal Layer
Dr. Bennett notes that often people’s intimate relationships become organized around the care-giving other people provide, and that “as soon as they start to improve, expectations and the relationship dynamics start to change.”
In family therapy perspectives, the “identified patient” (also “symptom bearer” or “scapegoat”) is a member of a dysfunctional system that has been unconsciously selected to express the distress of that system. Other members may profess concern for the identified patient, but may also react instinctively (and unintentionally) to any improvement by working to reinstate the status quo. What once seemed like an entirely biochemical illness can often be revealed as multiply determined when we notice loved ones’ discomfort with their ward slipping out of “sick role.” I have often felt concern in watching someone achieve remission, and then return to the same stressful environment in which the initial problems flourished. In less pathologizing terms, let us remember that there is a social expectation in the continuity of the self over time. People around us have adapted to how we typically act and express ourselves, and react with surprise when that shifts. Those reactions may subtly encourage us to return to our previous baseline. This is rarely intentional, but is extremely important to recognize. FOR PROVIDERS: Potential interventions to navigate through this period might include family therapy, couples therapy, or psychoeducation on the nature of family systems or group dynamics. We can assist clients in setting appropriate boundaries, and support them in having difficult conversations. FOR CLIENTS: If this is something you would like to address in your life, please talk to your providers about your specific situation and best practice interventions. It may be helpful to talk through how your relationships might change if your mood improves, or any fears of what might be expected of you if your condition shifts. In general, reading about and practicing Nonviolent Communication is a good way to improve relationships with the people around you.
Exploring Identity: Personal Layer
Much like our intimate others, we also have an expectation in the continuity of the self. When one has lived with a longer-term condition, there are ways in which it can get woven into one’s own identity. We become habituated to our capacities for activity and relating, and depend on our ability to predict how we might think and feel in any given situation.
It can be incredibly disorienting when a cluster of your regular experiences disappears overnight, and can foster a sense of not knowing yourself at all anymore. (This may be partly responsible for the “rubber band effect”–the tendency to return to our usual modes of being–that Dr. Phil Wolfson discusses in The Ketamine Papers.) Participation in online forums and support groups can provide invaluable insight and camaraderie; as helpful as this can be, it may also reify one’s social role as a fellow sufferer. We come to define ourselves as a depressed person, as someone struggling with fibromyalgia, as a recipient of Social Security or disability benefits. (Perhaps this is not such a novel occurrence, after all, as a similar phenomenon emerged with the advent of SSRIs. Peter Kramer noted in his 1997 book Listening to Prozac how his perspective on the nature of temperament was altered by witnessing responses to medication: “I was used to seeing patients’ personalities change slowly, through painfully acquired insight and hard practice in the world. But recently I had seen personalities altered almost instantly, by medication.” He reported similar disorientation and adjustment periods.) FOR PROVIDERS: Just as we would allow space for someone to discover new aspects of the self during a coming-out process, recognize that the remission period is also a fruitful period for exploration. Identity-making is an ongoing conversation throughout the lifespan. Acknowledge that with every new gain made, there are losses, and parts of our selves and lives that we are saying goodbye to. Inquire about the feelings that might arise during this phase. In our practice, we draw upon Internal Family Systems (IFS) techniques to help people have productive dialogues with different parts of their psyche, and discover (without judgment) what attachment to a depressed identity might mean for them. FOR CLIENTS: This is a time to look deeper at the beliefs you hold about yourself, and question their accuracy. You may consider getting reflections from someone who can listen neutrally and without agendas for your direction. A great self-help resource for IFS-style work is Jay Earley’s Self-Therapy. If you are concerned about returning to the workforce, many communities offer peer and professional support for those returning to work after a period of unemployment. This type of support should encourage autonomy, allow exploration of ability and identity, and avoid perpetuating disempowering ideas about what those with mental health struggles are able to contribute.
Letting it Out: Emotional Layer
Classic psychoanalytic conceptualizations regarding depression as “anger turned inward” can help frame the irritability or distress that may surface unexpectedly when symptoms remit. We have supported clients who, once they were relieved of depressive burdens, were then able to confront and feel appropriate anger stemming from past trauma, abandonment, or loss. This can be an incredibly healing process if one is supported by providers who understand the emerging emotional responses in context, but can be difficult to navigate on one’s own. Dr. Bennett has also observed anger and/or grief reactions, with people suddenly feeling “angry at God for making them sick, or at the situation, or all the doctors that didn’t help them previously…[W]hen this is buried or held down in the depression, and then starts to come up and out following treatment, people need therapeutic support to address that.” Though we think about depression as “sadness” and recovery as “happiness,” the reality is often not as simple. Depression can present with a numbing or flattening of emotions, and recovery may mean regaining access to a wide range of different feeling-states. Learning to navigate these states is essential. FOR PROVIDERS: Set expectations for all involved that recovery may involve unearthing unanticipated feelings and memories. Trauma-informed treatment is essential when working with some of these frozen states. Encourage safe expression of affect in session, and offer psychoeducation around appropriate assertiveness, boundary-setting, and anger management techniques. Teaching and practicing grounding exercises, such as the ones in the Seeking Safety protocol, can help people learn to re-regulate themselves when distressed. Additionally, Dr. Bennett notes that some continue to have suicidal ideation, but a critical shift occurs in its source, moving from a ruminative, painful “voice in your head that tells you that you’re better off dead,” to a response of grief, loss, or anger. She emphasizes the critical importance of attuned listening by clinicians to differentiate these sources, rather than assuming that the treatment was unsuccessful. FOR CLIENTS: If strong feelings are emerging during your treatment, please talk to your providers and request specific support for these states. If you are feeling suicidal, please reach out for help from your support network, call a hotline, or access urgent/emergency care. We recommend you do not navigate this process on your own. If you would like to learn techniques to manage anger, you may find an Anger Management Workbook useful. Interpersonal process groups and assertiveness trainings may also be appropriate. We highly recommend the grounding techniques from the Seeking Safety protocol for those looking to manage the overwhelm that results from a history of trauma.
Digging Deeper: Unconscious Layer
Above all, we must make space for the deeply personal and idiosyncratic responses people have to both their symptoms and the remission of those symptoms. We can not assume that this process has identical meaning for everyone we see. Honoring the uniqueness of the self and its adaptations to life’s challenges is part of what gives this work its beauty and depth.
Furthermore, meaning is held both consciously and unconsciously. Deep structures of the self are laid down early in life, in the interactions between temperament and environment, and are rarely available for immediate reflection. It is the work of ongoing inquiry in the therapeutic relationship to bring these templates into awareness. For example, I have had the experience of working with people who were eventually able to articulate their depression as the only link remaining with a lost loved one; there is a way in which these symptoms served as tributes to the depth of their connection. Rapid removal of these mood states may then trigger responses of loss and abandonment. Other clients have also formulated depressions as a coping tool itself: as a protective layer that prevents one from having to engage fully in life, an escape from having to make difficult choices, or an avoidance of confronting painful realities. Another example is indicated by psychoanalyst Patrick Casement in On Learning from the Patient:
I have noticed, with a number of patients, that the experience of feeling better is sometimes treated by the patient as a signal for further anxiety. Some analysts might treat this as a fear of losing the “secondary gains from illness.” Others might regard it as “negative therapeutic reaction.” However, I believe there are some occasions when a patient is indicating that an unconscious link has been formed between an earlier experience of trauma and the prior sense of safety, as if that “safety” had been a warning signal for the pending disaster. Perhaps an unconscious set is formed in which feeling safe and the subsequent catastrophe are seen as forever linked (1992, p. 364).
FOR PROVIDERS: Although psychoanalytic and psychodynamic frameworks are fundamental to understanding the operation of these deep templates, dogmatic adherence to any one theoretical system forecloses the open exploration of individualized responses. Curious inquiry and a desire to hear about any potential meanings that may arise go much farther than the most brilliant textbook formulation. In essence: “what does this mean for YOU?” It can be helpful to explore the relationship someone has with their depression, and how that relationship has changed over time. Narrative therapy ideas and practices can assist people in re-writing the stories of their lives into a more integrated personal mythology. FOR CLIENTS: Part of recovery inherently involves an investigation into the myriad internal, interlocking factors that keep us stuck in old ways of being. Though your situation will be completely unique, you are in fine company with the rest of humanity, as we all struggle to move out of safety and towards growth. If you sense that there have been ways in which depression has protected you from confronting difficult aspects of life, please make sure you begin to discuss this with your providers. Together, you may begin to re-author the tale of your history in a way that conveys respect for your resilience, as well as hope for the future.
Spiritual Crisis: Transpersonal Layer
We know that higher-dose journeys with ketamine can produce psychedelic, dissociative states, facilitating a profound transpersonal or mystical peak experience and expanding one’s sense of self and understanding of existence. Dr. Bennett shares that for some, this “contact with the Divine” can be intense and overwhelming, especially if there has not been much preparation for this self-expansion, and if one has been “out of touch with God for 30 or 40 years.” She also notes that the changes one can be called to make in one’s life following a peak experience can be disorienting. Psychic and spiritual content–especially following the use of psychedelics–can be mistaken for symptoms of psychosis in our highly secular culture. It is extremely important to differentiate between an illness process, and an enhanced sensitivity to transpersonal material. When held in a supportive context, these experiences can be extraordinarily meaningful to people. FOR PROVIDERS: Have conversations during the preparation phase about your client’s existential concerns, spiritual encounters, and beliefs about the nature of reality or the universe. Familiarize yourself with the techniques and mindset necessary for supporting someone during a spiritual emergence or crisis process. Contemplate the differences between a dark night of the soul vs. depression. Work to bracket your own belief systems in order to allow for free expression. FOR CLIENTS: Again, adequate preparation for working with ketamine, especially at higher doses, is essential. Please choose your guides wisely, and work closely with them to help you navigate these experiences. If you are troubled by existential or spiritual concerns following a journey and could use a framework for integration, contact the Spiritual Emergence Network for more resources, including spiritual coaches and helpful reading material. You could work with a provider that specializes in psychedelic integration, or attend a community integration circle. You may also want to seek spiritual guidance within an organized or non-organized tradition (whether Western, Eastern, indigenous, or other). The above linked material on grounding can be helpful if you are experiencing a great deal of energetic activation following treatment.
In practice, these layers are obviously intertwined, and interventions at one level may affect all others, as we present as whole beings, bringing surface-to-depth concerns to every interaction. As a final note: please know that none of this is intended to frighten you away from obtaining ketamine treatment, but rather to assure you that should you have these experiences, you are not alone, and that there are many ways to move through this phase without necessitating a relapse or causing untoward effects in your life. Being prepared for the possibility of the therapeutic bends often helps people feel less surprised or destabilized, and collaborating with your support team on how to handle this, should it arise, is of paramount importance.
Thank you so much for reading this post, and we welcome your questions and comments!
About the Author
Dr. Jessica Katzman is a licensed Clinical Psychologist with 19 years of experience as a therapist, and was trained at California Institute of Integral Studies (CIIS) in both traditional and transpersonal perspectives on healing. She is also certified as a Spiritual Emergence Coach, and approaches altered states of consciousness from a nonjudgmental, exploratory stance.
In her private practice, she specializes in integrating psychedelic experiences, supporting LGBTQQIAAP communities and gender-creative folks, addressing alcohol and substance use from a harm reduction perspective, body image issues, mood/anxiety disorders, social justice conversations, and navigating non-traditional relationships and sexuality.
After assisting a local ketamine infusion clinic with psychotherapy program development, she and our medical doctor joined forces to provide integrated Ketamine Assisted Psychotherapy for Healing Realms. She is supported by information received at the KRIYA Conference, an advanced training in therapeutic ketamine, and ongoing consultation with her colleagues in the field.
In this episode of Psychedelics Today we interview Emanuel Sferios, founder of DanceSafe and host of the new Drug Positive Podcast. The discussion mainly revolves around what “drug positive” means, MDMA, and harm reduction.
3 Key Points:
The history of MDMA is different than we have been taught.
MDMA is quite safe and the harms are very low. Risk reduction is a more appropriate term at times.
Emanuel is positive that his early drug experiences substantially helped improve his life.
Show Notes
There is an largely unknown history of MDMA.
Sasha Shulgin apparently was not the first to synthesize it in the modern era.
He created a new synthesis method.
MDMA was the first designer drug in a sense.
MDA became illegal and chemists decided to change the molecule
Manuel Noriega of Panama used MDMA at least once and gave permission to some chemists to manufacture in Panama shortly before the US invasion.
Harms from MDMA are quite minimal and small.
Parents who have lost a child can be natural allies to the drug positive movement.
Best practices for drug testing MDMA and Cocaine.
It is going to be really hard to convince the public to legalize drugs other than cannabis.
About Emanuel Sferios
Emanuel Sferios is an activist, educator and harm reduction advocate. Founding DanceSafe in 1998 and starting the first laboratory pill analysis program for ecstasy users that same year (now hosted at Ecstasydata.org), Emanuel pioneered MDMA harm reduction services in the United States. His MDMA Neurochemistry Slideshow has been viewed over 30 million times and remains a primary educational resource for physicians, teachers, drug abuse prevention counselors and MDMA users alike. Emanuel resigned from DanceSafe in 2001 and went on to work in other areas of popular education and harm reduction. He has recently come back as a volunteer. Oh! And he’s making a movie.
During this episode of Psychedelics Today, your host Kyle Buller interviews Duli Wilkins, aka the “Beantown Ghetto Shaman” about his work and future plans. In this conversation, Kyle talks to Duli about his work with sacred plant medicines, how he got involved in this type of work, and also explore the topic of people of color and diversity in the psychedelic world.
Show Notes
About Duli Wilkins
He’s from the Boston area born and raised.
He gives credit to his parents for getting him into what he’s into right now.
His dad used to play jazz music and met a bunch of famous musicians.
He learned that sound and frequency can be used as a tool for healing.
He lived between two warring projects.
A lot of his friends got into the gang life.
He got heavily into Tai Chi and Chi Kung.
He became a multi-dimensional healer
He had a friend who gave him a mushroom and that’s when the magic begins.
How did everything begin for Duli?
His empathic abilities heightened more when he used cannabis.
He started getting deeper into the teachings of Rastafarians.
In the black community, you didn’t see a lot of people using psychedelics.
Using a mushroom was very new to him.
Duli’s experience with mushrooms?
At first he just felt some tingling and checked on his friend looking at the painting.
He started to see things happen before they were happening.
He was seeing the fabric of reality.
He started having out of body experience and heard drumming from the heavens.
“What was it like for you to be involved in this work when the people around you aren’t?”
Things are changing, more people across the globe are becoming aware of the benefits of teaching plants.
A lot of people report seeing ancestors that have passed away.
There’s a resistance to psychedelics in the black community because of the history of drugs.
It was easy for the government to shut down everyone but their own children.
We have to be patient and time will bring things to the surface.
Discussion about the pharmaceutical system.
It’s great when you have a broken bone, etc.
The pharmaceutical establishment is a business and it runs like a business.
When we deal with ancestral memory or epigenetics the medical industry can’t touch it.
Safety in a teaching plant ceremony is key.
Discussion about the dark night of the soul.
Work in the shadow is important if you want to become whole.
We’re all walking around with trauma.
He’s had a lot of past life experiences, even one where his son died very young.
It takes a lot of courage to try psychedelics and you have to have a good setting.
“Do you see a lot of spiritual bypassing?”
Yes, people try to hide behind things.
Some people hide behind the psychedelics.
Psychedelics and teaching plants are tools, how are you using the tools?
When we deal with wealthy people, maybe it’s the lack of struggle to obtain psychedelics.
There’s much more to us and as time goes by we’re going to have disclosure.
Duli talks about some experiences with extraterrestrials during psychedelic trips.
We’re going through cycles and making the same mistakes every time.
Last words?
Find him on Facebook under @abdukwilkins
Find him on YouTube under The Beantown Ghetto Shaman
Sign up for our free online course
Episode Quotes
Something inside me said, I should take the mushroom and that was the gateway to shamanism.
Things are changing, more people across the globe are becoming aware of the benefits of teaching plants.
We have to have a re-education and awareness around teaching plants.
About Duli Wilkins, a.k.a Duli Tha Beantown G.H.E.T.T.O Shaman
Abdul K. Wilkins a.k.a Duli Tha Beantown G.H.E.T.T.O (Gifted. Hearts. Equal. Towards. Total. Oneness) Shaman is a Boston Native…He grew up in the Inner City of Roxbury where he overcame an environment of gang street violence, neighborhood drug abuse, and police brutality! Duli was influenced at a young age by both of his parents in the interest of spirituality, mysticism, natural healing etc.
While attending College at Northeastern University he had a very mystical experience with psilocybin mushrooms and has been using mushrooms and other psychedelics as a tool for healing and conscious awareness ever since! He is a father of 2 and does massage therapy and natural healings in his community!
During this episode of Psychedelics Today, Kyle Buller interviews Dr. Richard Grossman, an ayahuasca ceremony facilitator and expert with a background in healing and acupuncture.
Episode Quotes
I find mystical poetry to be an amazing aid in ceremony work.
Is it the vision or the emotion that you feel and then the vision comes?
In my work, the psychedelic experience is about going beyond the visionary state.
The core of all creation is in the heart and breath.
Show Notes
About Dr. Richard Grossman
Has a long background in healing.
He used to be a macrobiotic chef.
Primeval meditations and licensed acupuncturist.
Works with ayahuasca and San Pedro.
How did Richard get involved in ayahuasca?
A friend brought some up from Peru and his life changed in one night.
It took him years as an acupuncturist learning more about healing.
He’s been doing this for about thirty years.
Do you integrate your acupuncture practice into ceremony?
Not so much with ayahuasca – that’s done traditionally.
He had a lot of experience with the Shipibo Tradition.
With the San Pedro method, the body change happens in one day.
Opinions on psychedelic visions.
Many people want them and they’re a distraction.
The real thing is that the source of everything is within.
If a person can experience that for an instant, their life changes.
There are a lot of things happening on subtle levels.
The psychonaut and healing processes are quite different.
What are some examples of ideas you’ve seen in the psychedelic community?
People trying to draw in gods and goddesses.
You need to see how deep a human being can go, it’s an infinite journey.
What is it like to go deeper and deeper?
If you can imagine a series of curtains parting over and over and over again.
You begin to see places of illusion.
During one of his trips, he visualized himself in a Nazi concentration camp.
A voice told him to trust and forgive.
He began to question what forgiveness and trust mean.
Some people are seeking spirituality and not really healing within.
Ayahuasca tourism is a fairly good thing, rather than people coming and ruining the jungle.
How would you define a healing process?
It’s a complex subject, he likes the idea of a series of concentric circles.
Do you work with a person’s energy?
People get very relaxed.
If there is someone who can’t get relax he calms them with acupuncture.
Do you think intoxicants affects the chi?
San Pedro or ayahuasca are not considered intoxicants.
He sees that ayahuasca is only good for the body.
Psilocybin has a rough effect on the liver.
The tannins in ayahuasca are valuable and bind toxins in the body.
Do you have to worry about any cardiovascular problems?
It is a stimulant so he screens people before doing the ceremony.
Beauty is a healing process, beauty heals.
Is there anything you’re excited about in the psychedelic world?
When the community comes together to heal it’s powerful.
We’re all going to a place of more love, peace, joy, and healing.
What’s the outcome of thousands of people experiencing love and joy?
What’s the ayahuasca ceremony structure?
Constant music, keeping things from going totally wonky.
There’s a point in the ceremony that it could go in either direction:
Total group insanity or total group healing.
Iowaska ceremonies can be dangerous.
It’s something to be respected with its own spirit.
You must hold close to the traditions of generations.
There’s always a point during the ceremony where he feels it’s the most important and beautiful place he’s ever been.
Drama’s not necessary, our culture wants the drama.
We need to outgrow externalizing the blame.
Life in our heart is meant to be enjoyed.
Suffering to heal just doesn’t work.
Culture seems to dwell on suffering, is that conditioning?
The worst thing a human can possibly do is feeling guilty.
“Guilt can’t fly and God wants you to fly.”
The nature of reality is joy and love.
You need to be willing to let go of the things that don’t work.
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About Richard Grossman, L.AC., O.M.D., Ph.D.
Richard Grossman studied Oriental Medicine at the California Acupuncture College in Los Angeles and received his post-graduate acupuncture training in Beijing, in a course sponsored by the World Health Organization and attended by physicians from around the world. He earned a Masters in Acupuncture, a Doctor of Oriental Medicine degree, a Ph.D. in Oriental Medicine, a Diplomat in Acupuncture, a Diplomat of Pain Management, and a Diplomat in Acupuncture Orthopedics.
Psychedelic science and research has been getting a lot of mainstream media attention over the years and for good reason. The preliminary research suggests that psychedelics may be extremely beneficial in helping to treat mental health disorders and as tools for studying consciousness. As this research begins to hit mainstream channels, some people are left wondering, “How can I find a psychedelic guide or sitter?”
We, at Psychedelics Today, have been receiving a lot of requests from people asking for instructions on how to obtain illegal drugs or for us to connect them with people offering underground services. While we understand that many people are suffering and seeking psychedelic treatments, sometimes out of desperation for healing, it is not easy to provide advice. Unfortunately, because of the legal system and the current laws in The United States, we are unable to help you on either of these fronts.
With that stated, we can provide some general advice for those looking for alternatives or legal options. Please take the time to conduct your own research as well.
First Things First
It is important to question what your intentions are and ask yourself why you may be seeking psychedelics either as therapy or as an experience.
Are you seeking a therapeutic experience because of a mental health issue?
Are you seeking a psychedelic experience for spiritual or religious reasons?
Are you just curious to know what the experience may feel like or what it is all about?
Are you looking for a recreational experience or to have fun?
Whatever your reasons or intentions are, it is important to continue to be self-reflective and question whether or not this is the right path to pursue. Also, be sure to spend time reflecting on the risk/benefit ratio.
While psychedelics are generally considered safe both psychologically and physiologically, there are some important considerations to take into account. These medicines and substances affect everyone differently based on the set and setting as well as a person’s own biology.
If you are seeking a psychedelic experience because you are suffering from a mental health issue or looking for psychological healing, it is important to evaluate whether or not it is the best option. The research is promising, but it also requires a lot of work, support, and follow-up treatment. Psychedelics are not always cure-alls or silver bullets.
If you are seeking this treatment out of desperation because you have read how positive or healing the experience can be, it is important to note that this change does not always happen right away. It may be important to find a psychedelic integration therapist to work with after or before. Also, ask yourself, “Have I tried other options?”
There are some powerful and effective somatic-based therapies that can be extremely cathartic and healing, such as breathwork, Somatic Experiencing, and others. A list of alternatives and somatic-based therapies can be found below in the “Experiential Therapies/Approaches” section. These therapies may be worth checking out if you have not looked into these therapies before and may also be a great first step to working with non-ordinary states of consciousness.
Exploring Legal Psychedelic Therapies and Other Alternatives
Experiential Therapies/Approaches
One thing that comes to mind is why are you looking for a guide? Is it to heal trauma or some sort of mental health issue? Are you looking for a spiritual experience or a way to reconnect with yourself? Depending on your intention, there may be other techniques and tools. It may not be as “sexy” as partaking in psychedelic work, but it is important to ask yourself, “What is my intention?”
There are some really powerful therapies and techniques that could potentially be helpful depending on the intention. In regard to therapy or addressing mental health issues, starting with a form of experiential therapy could be beneficial. You could look into some of these somatic approaches that could be helpful for dealing with trauma and other mental health issues before trying to seek underground work or travel outside of the country to work with psychedelic medicines.
Finding/working with a shamanic practitioner may be helpful for some as well. The Foundation for Shamanic Studies (founded by Michael Harner) is a good starting point for finding a practitioner to work with.
Legal Therapy Options
Ketamine-Assisted Therapy
Ketamine is an interesting substance and has recently been used to help treat depression. There are ketamine clinics throughout the United States that provide treatment for depression and other mental health issues. If you are interested in learning more about ketamine-assisted therapy, check out a few of our episodes covering the topic.
Cannabis-Assisted Psychotherapy
While many people do not think of cannabis as a psychedelic, some are exploring the therapeutic potential of cannabis in a legal and therapeutic setting. There are not many clinics operating with this protocol, so it may be hard to find, but as cannabis becomes legalized in more states for medicinal use and recreational use, this may become more accessible. Here are three resources that we know of so far for cannabis-assisted psychotherapy.
Did you know that when cannabis is used intentionally and skillfully, it is psychedelic and mimics other psychedelic medicines? Our participants commonly report experiences quite similar to MDMA, Psilocybin, Ayahuasca and even DMT. Cannabis is also safe, and legal to use in Colorado in this way. As the first organization to facilitate legal psychedelic cannabis experiences in Colorado, beginning in 2014, Medicinal Mindfulness has an incredible track record of keeping our clients safe and creating profound, life changing psychedelic experiences.
Conscious Cannabis Experiences are perfect for people who are curious about psychedelics but don’t know where to start. They’re also great for experienced practitioners seeking to deepen their psychedelic practice. As trauma informed practitioners, we also work with individuals who seek deep, transformational healing. As guides, we work with creative explorers of consciousness and complex problem-solvers, pushing the edges of what is possible.
Innate Path: Ketamine and Cannabis-Assisted Psychotherapy
Innate Path, located in Colorado, is exploring the potential of cannabis-assisted psychotherapy and ketamine-assisted psychotherapy. As mentioned on their site, “Cannabis can be a powerful catalyzer of therapeutic process.”
Innate Path combines somatic processing with ketamine or cannabis assisted work, which is a unique bottom-up approach to psychedelic-assisted therapy.
Sara Ouimette Psychotherapy, located in Oakland, CA, offers psychotherapy, psychedelic integration services, and cannabis-assisted psychotherapy. As stated on Sara’s page:
When used in a particular way, cannabis can actually amplify or exacerbate your internal experience. You can become more aware of tightness or soreness in your body. Emotions are heightened; senses are more acute. You may have access to thoughts, fears, and feelings that are normally out of reach. You may even enter a trance-like state and “journey.” In these ways, cannabis can help deepen your therapy process.
One way to find a psychedelic sitter/guide is to participate in clinical research. Check out the following for more information.
Clinicaltrials.gov: This is a database of clinical studies from around the country and around the world. You can use this database to search active clinical studies on psychedelics and to search for recruitment opportunities. Just perform a simple search for “psychedelic” or anything else that you may be looking for in the search box. You can filter your search option and only search studies that are currently open for “recruitment.”
This option is not always available to everyone because of the cost of travel, accommodations and other expenses. While we understand attending a retreat or center in another country is not accessible for most, it is one of the few legal options for participating in this work. We advise doing extensive research including interviewing the retreat staff/owner and past guests before committing to international travel.
One site that we recommend for finding retreats or reviews is the Psychedelic Experience. While this site is still growing, this may be a great starting point for research. Another popular site is AyaAdvisors.
Psilocybin Retreats
Traveling to another country to participate in this work is obviously not ideal, but the option exists. Mushrooms are legal in The Netherlands, Jamaica, and Brazil. Mexico has protection for traditional medicines, and mushrooms do fall in this category.
Ayahuasca Retreats
Ayahuasca has an interesting legal status in the USA, where many groups are offering sessions in various contexts and settings from religious ceremonies (Christian or shamanic), YMCA gyms, rural retreat centers, churches, etc. Ayahuasca is legal in some countries like Peru and Ecuador. Ecuador provides licenses for shamans/facilitators while no other countries currently do.
Ibogaine Retreats
These retreats exist in Canada, Mexico and other countries around the world including where the plant is from and traditionally used – Gabon. Some facilities are very clinical and others are very traditional. Please know that Iboga and Ibogaine have some serious dangers that need to be carefully considered. There are also environmental concerns around iboga. Please don’t over-use this plant and if you go forward with it, please try to give back to the local environmental movements in Gabon.
5-MeO-DMT Retreats
We currently don’t advise people go on these retreats. The pressure on toad populations is severe and our culture’s desire for the toad venom may push this toad towards an endangered status. After interviewing toad scientists (herpetologists) we have concluded that it is not ethical to be participating in this “market”. If you feel very compelled, the more ethical path (at this point in history) is to work with synthetic molecules.
Holotropic Breathwork and Transpersonal Breathwork
Breathwork is a term used to describe breathing techniques and systems that foster self-discovery, healing, and sometimes deeply emotional and physical cathartic releases. If you have been following Psychedelics Today, you have most likely heard us talk about this technique on the show. Breathwork is actually a legal and safe way to access a non-ordinary state of consciousness. There are various schools of breathwork, but the Breathwork technique that we are most familiar with is in the lineage of Holotropic Breathwork and Transpersonal Breathwork. Holotropic Breathwork was created by Stanislav Grof, who was a pioneer in psychedelic research in the early years, and his wife Christina Grof. Breathwork can sometimes be on par with some psychedelic-like experiences.
It may not sound as sexy as psychedelic work, but do not be fooled, it can foster powerful shifts in consciousness. We have both had tremendously powerful healing experiences using Holotropic Breathwork, which plays a huge part in why we talk about it so regularly.
Conscious Breathwork and Conscious Cannabis | Medicinal Mindfulness
Medicinal Mindfulness is a Colorado-based organization that provides services in psychedelic integration, breathwork, and conscious cannabis work. Medicinal Mindfulness is a consciousness community/membership organization and education program that supports individuals and groups who choose to use cannabis and psychedelics with intention and skill. Through our Community Breathwork and Conscious Cannabis Events, we facilitate legal, accessible, safe and sacred psychedelic journey experiences that integrate the four primary paradigms of intentional medicine use: Creative, Scientific, Psychological & Spiritual. Our approach is Transpersonally aligned and somatically oriented.
You can learn more about the work at Medicinal Mindfulness on this episode of Psychedelics Today with the founder, Daniel McQueen.
Conclusion and Legal Notice
Finding an underground therapist to work with is extremely difficult because unfortunately, many of these substances are still illegal. This is why we often refer people to check out techniques like Holotropic Breathwork or to find a legal way to pursue this type of work. Remember, many underground guides are putting their professional careers and lives on the line providing psychedelic work.
We advise you to learn as much as you can before breaking any law as the consequences can be severe. If there are any questions that you think are serious enough to cause harm to yourself or others, please contact a legal professional before acting.
Psychedelics Today, LLC and its affiliates can not be held liable for any action you take. We are not doctors and therefore, cannot provide any medical advice. Please be responsible and seek professional attention when necessary.
Best of luck out there, and expect us to share as much as possible when the laws change.
In this episode of Psychedelics Today, host Joe Moore interviews Dr. Benjamin Malcolm, professor of pharmacy at the Western University School of Pharmacy. The discussion revolves around ibogaine, alkaloids, and addiction therapy solutions.
3 Key Points:
Opioid addiction and death related to overdose is a public health epidemic in the United States
Addiction may be rooted in loneliness, boredom, lack of recreation, trauma, pain or disconnection
Ibogaine is able to reduce physical symptoms and cravings of opioid withdrawal and usually provides the user with insight into why they developed an addiction.
Show Notes
Dr. Benjamin Malcolm discusses psychedelic alkaloids that have the potential to treat addictions.
When conducting research with human subjects, an Institutional Review Board (IRB) should review the project proposal to ensure the study is ethical
There are risks involved in taking in ibogaine that can be used to treat addiction with deaths due to cardiac arrhythmias reported
In the United States, opioid overdose claims over 100 lives every day
Ibogaine is illicit in the US and unregulated in other parts of the world
Psychedelics that bind to 5HT2B receptors could cause a thickening of the heart valve if taken on a chronic basis, psychedelics taken intermittently are not likely to have a significant effect
Many newer synthetic psychedelics have not been studied in animals or humans, leading to the potential for unknown adverse reactions
Internet surveys about psychedelics usually have a selection bias due to those enthusiastic about the subject to fill out the survey while those that had negative experience may not fill it out or even access websites or forums where surveys are distributed
Mescaline is a classic psychedelic (found in San Pedro or Peyote cactus) with much anecdotal evidence of benefit that has not been the featured in any well designed human research
If psychedelics become approved drugs for medical use then managing transitions between traditional pharmaceutical modalities and psychedelic-assisted psychotherapies will be required and may be an important area of pharmacist involvement in psychedelic-assisted psychotherapies
Professionally, I teach psychopharmacology and clinical psychiatric pharmacy, practice as a clinical specialist in psychiatric pharmacy, and perform research on psychoactive drugs.
On a more personal note, I’m a lover of nature, exercise, music, being, and consciousness. I’m passionate about cognitive liberty, self-realization, and psychedelic drugs.
I envision a society in which access to psychedelic drugs in a variety of safe and supported settings is available for purposes of psychospiritual well-being, personal development, ceremonial sacraments, and treatment of mental illness.
A few important notes. This is an episode of an individual experimenting with powerful drugs to see if he can get any sort of relief from autism. In this case, it appears to have been successful. That said, this came with a substantial amount of risks, and people need to be aware. Please read the below bullets so you understand.
Autism is not what is treated. The thing being treated would be a symptom like social anxiety.
“The field of autism science includes a long and shameful history of quack treatments and parents taking desperate and harmful measures to “fix” their children. Autism is a spectrum of congenital and neurocognitive variants, and there are no published research data in support of any compound that can influence its course.” Alicia Danforth, PhD
Please do not administer these drugs to children with autism.
There are only two researchers investigating where MDMA and autism meet – Alicia Danforth PhD and Dr. Charlie Grob. A scientific paper will likely be available on this in the next few months. Expect to see more here.
These drugs have not been shown to cure or treat autism, but in some cases, just like with neuro-typical individuals, some have seen meaningful changes.
Even if changes are noticed the person is still autistic no matter how many high doses of psychedelics they take.
Obtaining pure drugs is very difficult if not impossible in black markets.
Verifying purity will require the resources of mass spectrometry from organizations offering these services like Energy Control or Ecstasy Data
Providing unsafe, dirty or compromised drugs to people can cause serious harm or death.
If you are planning to use MDMA to alleviate some suffering on your own, please wait or don’t.
Do substantial research and have skilled people available to help.
Thanks to Alicia Danforth for helping us understand the nuance’s in this area.
..autism is a genetically determined cognitive variant. It’s pervasive, and it affects the whole person, not just the brain. No chemical compound has been shown to treat, cure, or alter the course of autism. However, for some people, substances like MDMA can help them manage symptoms such as anxiety, social anxiety, and trauma effects. – Alicia Danforth, Ph.D
Introduction
Joe Moore and Kyle Buller interview Jon and Dre of the Voices in the Dark podcast out of England. The discussion addresses treating symptoms of autism with MDMA and LSD, what types of doses were used, and how to in part do it safely. Note there are always risks with any kind of drug. Learn the basics over at our Navigating Psychedelics course.
3 Key Points:
A lot of autism is sensory overload. As far as emotions are concerned, “we “see potentially too many things in other people’s faces.” – Dre
A good range for MDMA dosages is between 100mg and not going over 200mg.
125 micrograms per drop of liquid LSD, and not going above 250 micrograms is recommended.
Show Notes
Jon’s first psychedelic experience shifted his academic career path and helped him to deal with depression.
Dre first tried MDMA as a first step and it unlocked emotional empathy.
Sensory overload is a lot of autism according to Dre.
Jon’s experiences with MDMA made him feel like himself without the fear and the worry.
MDMA and LSD at the same time didn’t feel as emotional when combined to Jon.
125 micrograms per drop of liquid LSD, and not going above 250 micrograms is recommended.
Democratising psychedelic therapy is where Joe would like to see the industry go.
Jon is against the fetishizing of any particular concept of belief system in its totality.
Jon is excited that he is starting to see more types of research on LSD/MDMA and autism.
Dre’s experiences have shifted his autism by feeling that he has a foot in both worlds to know how living without it feels in his mind.
At Voices in the Dark, we bring you powerful, mind- and soul-expanding conversations about real life psychology, philosophy, psychedelics, spirituality, social dynamics and much more.
We’re a podcast, a blog, and a community of likeminded individuals who want to become the best versions of themselves. We’re dedicated to never stop Learning How To Human.
Our mission is to entertain, provoke, inform, and make you question everything you think you know.
DRE
A disturbingly quick study in most fields, Dre’s autism made learning people more of a challenge. The works of Robert Greene shone a light on the otherwise deeply confusing world of other people’s psyches, transforming the world around him into something which finally made sense.
JON
After spending far too many years in educational institutions, Jon got a PhD in History but is now finally learning something about the real world and the people in it. He always felt that science and scholarship needed more dick jokes and is on a mission to redress that balance. He writes, talks, travels, sings, and has a problematic relationship with cake and coffee.
Download In this 88th episode of Psychedelics Today, host Joe Moore interviews Mike Brancatelli of the Mikeadelic podcast. After returning from a three-month Amazonian ayahuasca sojourn, Mikeadelic himself shares information about this extraordinary experience, how he has gotten involved in psychedelics and his journey.
Show Notes:
● Mike Brancatelli spent his three-month trip in Peru at the Temple of the Way of Lights with their residency program in the heart of the Amazon jungle during an ayahuasca retreat.
● Mike was previously doing stand-up comedy in New York City with his friend Dave Smith called “Part of the Problem.”
● Mikeadelic the podcast began in the spring of 2016.
● Drinking ayahuasca will produce an effect on you, especially when coupled with ceremony and healing songs.
● During an intense healing ceremony, a song cut to the core of the collection of pain that Mike was experiencing, and it felt like he was being unclogged of this negative energy, and it came out in the form of a very vocal purge.
● He feels passionate about ending the war on drugs and the prison industrial complex.
● You can remain filled with passion and compassion without being emotionally attached. Sit with your feelings without letting them control how you respond.
● The information overload of media drowns your spirit.
● A morning routine with meditation is helpful to get centered and focused for the rest of the day.
● The Netflix TV series “Wild Wild Country” is a true story about a controversial cult leader claiming to enlighten people.
● “Enlightenment Now” is a book about the enlightenment philosophy “science, reason and humanism”. It is a contemporary take on that philosophy – you could call Pinker’s take a Modern Enlightenment philosophy. Steven Pinker wrote the book. Joe Moore, suggests it and found out about it from the Bill Gates’s.
● “The Internet of Money” Volume 1 and Volume 2 by Andreas M. Antonopoulos is another interesting read suggested by Joe Moore.
● Before ayahuasca use, listen to your heart to understand why you want to try it.
3 Key Points:
1. During an intense healing ceremony, a song cut to the core of the collection of pain that Mike was experiencing, and it felt like he was being unclogged of this negative energy, and it came out in the form of a very vocal purge.
2. It is incredibly brave to be willing to confront your stress and be willing to stare into your soul and slay your demons.
3. Remain passionate, compassionate, and acknowledge the problems in the world, but don’t stay emotionally attached to them. Become mindful of how you respond.
In this episode of Psychedelics Today, host Joe Moore interviews Daniel McQueen, Co-Founder of Medicinal Mindfulness and the DMT research project called DMTx. They discuss the extended-state DMT research project that they are involved in, the personal DMT trip experiences that Daniel McQueen has had, and what this research can make possible.
3 Key Points:
Daniel McQueen does private retreats, groups, conscious cannabis circles, healing meditations, and community breath work.
Goals for called Extended State DMT research include healing clinical concerns and advanced creative problem-solving with experts that need assistance.
We are four-dimensional beings in an 11-dimensional reality.
Daniel’s story of a very intense and meaningful DMT experience
Depth Psychology is trying to bring things from the subconscious to the surface.
Humanist Psychology is based on what it means to be human and the human experience.
William James is one of the fathers of Transpersonal Psychology, which integrates the spiritual and transcendent aspects of the human experience with psychology.
Psychedelics Today has partnered with Daniel McQueen of Medicinal Mindfulness on a project called DMTx (Extended-State DMT research) which involves using an IV pump to keep a steady stream of DMT in the bloodstream for a long period of time.
Daniel McQueen does private retreats, groups, conscious cannabis circles, healing meditations, and community breath work.
DMT is “the most profound hallucinogen that we have access to.” It doesn’t lose its effect the more you use it.
Once you hit the peak of the DMT trip during Extended State DMT you stabilize.
People have been overwhelmed when smoking DMT because the dosages may have been too high with a lack of a sense of meaning—an overdose of stimulation.
A peak experience that Daniel had was slug beings showing the soul of his unborn child.
After his second child was born, Daniel had another trip where an authoritative being searched for the soul of his child that had now been born.
The risk is low but bad events not handled properly could involve: a cardiac arrest, situation even though there are no known cases and psychological crisis and mania.
Daniel is working towards a DMT travel exhibition with four experiences included.
Spiritual traditions will be integrated into the research to acknowledge the spiritual possibilities.
Goals for the project include healing clinical concerns and advanced creative problem-solving with experts that need assistance.
Daniel believes psychedelic medicines give us the potential to see things beyond three dimensions.
What happens when our culture is literate to the psychedelic space?
There is a moral case to make to prevent people using altered states to create more advanced dangerous weapons.
We are four-dimensional beings in an 11-dimensional reality.
Why can’t we use a more scientific approach to move towards spiritual awakenings?
Daniel discovered meditation and spiritual practices at twelve and has been interested in exploring inner states ever since. He apprenticed under a number of shamanic teachers and has been a practicing intentional journeyer for over 16 years. For Daniel, working in the professional field of Cannabis and Psychedelics isn’t a career interest, but represents a core identity and life calling. Finding a place to honor such a life calling within a world that has until recently prohibited it has been an interesting challenge.
After graduating from the University of Arkansas with a degree in Communication, Daniel traveled down a many forked and unmarked road through the wild terrain of political activism, corporate accountability research and campaign finance reform for many years in Washington, DC. Disillusioned by the city, he moved to Florida and opened a small meditation center to explore grassroots community organizing before moving to Boulder, CO and returning to school at Naropa University.
Daniel earned a Masters Degree in Transpersonal Counseling Psychology from Naropa and received advanced training in MDMA-assisted psychotherapy through a year internship with the MAPS Boulder MDMA for PTSD Study. It was his experience with MAPS that inspired Daniel to explore alternative visions in cannabis and psychedelic activism and entrepreneurship.
Daniel bridges transpersonal paradigms with the grounded clinical and organizational skills necessary to begin addressing the significant ecological and mental health crises facing our society today. Although Daniel no longer practices as a clinical psychotherapist, he supports his clients as a teacher, coach, ally and event facilitator, providing individual and group transformational experiences and deeply held intentional conversations. In his practice, Daniel quickly realized that the most important intervention he could provide to his clients, who were isolated and longed for meaningful contact with others, was a sense of community. Medicinal Mindfulness is, in a very real way, a cultural intervention that provides a safe and transformational community container for healing and awakening… a program based on skill development and not dogma. Since 2012, Daniel has been teaching a psychedelic harm prevention and intentional psychedelic use course called Psychedelic Sitters School. Since the legalization of recreational cannabis in Colorado, he has been facilitating group journey experiences called Conscious Cannabis Events and guiding individual cannabis journeys.
In addition to his work with Medicinal Mindfulness, Daniel has a successful spirituality and life coaching practice with his wife, Alison, through their company, Aspenroots Counseling LLC. Highly skilled in identifying and cultivating giftedness in young people and supporting significant life transitions, Daniel is inspired to support passionate and talented individuals striving to live into their calling. A primary focus of his practice involves assessing and addressing the benefits and difficulties related to psychedelic and cannabis use and misuse.
Daniel co-founded the Naropa Alliance for Psychedelic Studies and helped organize the first annual Psychedelic Symposium at Naropa University in 2012.
About Medicinal Mindfulness
Medicinal Mindfulness® LLC and Medicinal Mindfulness Events LLC
Medicinal Mindfulness is a grassroots consciousness community/membership organization and education program that supports individuals and groups who choose to use cannabis and psychedelics with intention. Founded by Daniel McQueen, MA, and his wife, Alison McQueen, MA, our community has come together to provide an enjoyable, safe, open and affirming space to share transformational cannabis and breathwork experiences.
We use clinically informed, mindfulness-based approaches within a somatically oriented, transpersonal and community paradigm to create an holistic (mind, body, spirit) process that initiates powerful transformations in healing and personal development.
Services are available for individuals, couples, families and groups.
Given the common misunderstandings and concerns that accompany the field of psychedelics and cannabis harm prevention and advocacy, we are committed to making ourselves available to public service and safety professionals to answer questions regarding psychedelic and cannabis harm reduction programs.
During this episode of Psychedelics Today, your hosts Kyle Buller and Joe Moore talk to Zach Leary host of the MAPS podcast and It’s All Happening. We have an incredible time talking to Zach and his worldview, experiences, opinions and much more. It was a very fun time recording with Zach and we hope it can happen again in the near future.
Show Notes
Joe and Kyle discuss Zach’s connections with Ram Dass
Zach Leary calls himself a futurist and we discuss what a futurist is.
A natural way to continue the narrative of our physical evolution and our spiritual development.
Cyberspace is an invention as a result of our human condition.
The way and the reason we invented it is that we found a need to create another dimension.
Futurism and transhumanism and embracing the way technology is augmenting the human experience is a great place to be.
Do you see any major problems in psychedelia?
Overall, it’s a great time to be into psychedelics.
There’s so much research and data available to the end-user and the discussion is improving.
Many people are starting to be more open about their beneficial relationship with psychedelics.
It’s important to get people in the mainstream aware of their beneficial properties.
The Ayahuasca fad going on in the U.S. has many people calling themselves shamans, which raised a red flag to Zach.
It used to be that going to the medicine man was a common occurrence in any culture.
Mysticism didn’t go away, it just got turned into a more doctrinal practice.
The part of the church that bothers Zach is the authoritarian aspect, that there is only one god.
There’s an element of fanaticism when someone says there’s only one drug that’s worth taking.
April 19 is the 75th anniversary of the first intentional use of LSD (Bicycle Day).
We have to start re-thinking about what “natural” means.
The human imagination and what it creates is a by-product of nature.
There’s no stopping the technological march, the train has left the station.
A return to nature can include biodiverse rooftop gardens in New York.
It’s very hard to get off the grid.
What do we have that’s readily available and sustainable?
Mushrooms
LSD
Other synthetic compounds that don’t bother the rainforest, etc.
Zach is the host of both the “It’s All Happening with Zach Leary” podcast and “The MAPS Podcast.” They have helped to cement him as one of the most thought provoking podcasters in the cultural philosophy genre of podcasting. He’s also a blogger/writer, a futurist, spiritualist, a technology consultant and socio-cultural theorist.
In all of Zach’s work he blends his roles as a spiritual aspirant and a futurist into a unique identity all his own. His spiritual background has it’s roots in being a practitioner of bhakti yoga as taught through many of the vedantic systems of Northern India, in particular Neem Karoli Baba as taught by Ram Dass. Through the practice of bhakti yoga he has found keys that unlock doorways that allow the soul to experience it’s true nature of being eternal, full of knowledge and full of bliss. In addition to bhakti yoga, Zach is influenced by many different methods and traditions of consciousness exploration ranging from trans-humanism to buddhism and clinical psychology. Zach is also a frequent pundit on the political systems that are fueling todays economic and cultural structures. At the core of all of Zach’s work is the belief that we have been fused together by the collective practice of using technology to expand our species imagination with spirituality and mysticism to define the very nature of who we are.
During this episode of Psychedelics Today, your hosts Kyle and Joe Moore talk to Dr. Matt Segall, a philosopher with a Ph.D. working at CIIS as an administrator and adjunct lecturer. In this episode, we explore psychedelics through the lens of philosophy and Alfred North Whitehead.
Show Notes:
Philosophy is really important when talking about psychedelics.
This movement is working on a lot of different levels.
Looking to get accepted into academia therefore it’s important to be precise.
About Dr. Matt Segall
Strong interest in Alfred North Whitehead
12 levels of abstraction away from Plato.
Ropes in all of western philosophy and science into a cohesive system that seems to reenchant the world a bit.
Extended state DMT research
Use an IV pump to keep a steady stream of DMT in the bloodstream for an undetermined amount of time.
The initial phase of the study is 10-20 minutes.
Not just for medical research, it’s for the community.
Join the class at psychedelicstoday.teachable.com.
How did Matt Segall stumble his way into the Whitehead world?
Philosophy came first, but not by much.
He had a teacher who introduced him to some psychedelic teachers.
His first experience with psychedelics was when he was 19 years old with mushrooms.
He realized that there were many other worlds running in parallel with this one.
These substances open up our perceptions of other worlds and other facets of the same world.
We need to incorporate the experience induces by these substances.
Western philosophy is rooted in the psychedelic experience.
Plato’s encounter with the ideal forms that led him out of the cave proves that the origins of philosophy include psychedelics.
There is chemical evidence that the rituals in Athens were psychedelic in nature.
When ancient Greeks refer to wine, they’re talking about something that was way more mind altering.
What drew you into Whitehead?
In college, he listened to a McKenna lecture and he mentioned Whitehead a lot.
McKenna introduced him to Whitehead.
He waited until he started graduate school, so he could take a course on him and study him alongside other graduate students.
Whitehead incorporated 20th century physics and a version of Darwin’s understanding of evolution expanded to a cosmological level.
Combining advanced science with an enchanted view of the universe.
The modern era has alienated human beings from the rest of the natural world.
The industrial revolution made this alienation even more profound.
There has been a gradual isolation of the human being from the rest of life and the universe.
Human beings have come to think of the rest of life and just robots seeking to reproduce.
Value has to be assigned to anything non-human by humans.
This thinking is highly destructive.
Our idea has not fit the reality and it’s destroying the reality.
Whitehead helps us re-inhabit the planet as one of the many species.
When human beings come to recognize that value is not just made up in our human society but it’s an intrinsic cosmic value, they can act accordingly.
Whitehead’s process is called a process-relational process.
We’ve traditionally been thought to have a soul or mind that’s independent of others.
Whitehead proposes that our soul or mind is in relation to others.
So that what it means to be me is that I’m not unique, but my uniqueness comes from my unique perspective and works with the other souls in the environment.
This attempts to move us away from thinking of ourselves as isolated minds.
The biggest challenge is to get people to not shut down when they see Whitehead’s terminology.
Philosophy can serve to help us develop a language that actually serves to represent our experience.
It’s well worth it to learn the dictionary that Whitehead provides.
Whitehead’s understanding of perception is welcoming more indigenous ways of knowing back into the realm of philosophy.
Whitehead helps us make sense of indigenous experience.
All of human culture stems from these shamanistic practices.
We don’t yet have the words to explain yet what these psychedelic journeys are doing to us.
A downside to being in the west is that we don’t have relationship with psychedelic substances.
The plants that are a part of the ayahuasca brew told the indigenous people how to brew them.
People talk about nature deficit disorder, kids being raised indoors being told the outdoors is dirty.
The problem is not one of trying to reinvent the wheel, we have to stop beating this capacity out of children.
When we talk about the human nervous system in the context of symbiotic relationships with our ecosystem:
It doesn’t make sense to consider the human brain and nervous system as enclosed within the skull.
The human nervous system is actually a lot more ecological in its extent than most physiologists would let on.
The chemical metabolism of our brain extends out into the environment.
Richard Doyle wrote a book called Darwin’s Pharmacy where he coins the term “ecodelic” which challenges the idea of an autonomous individual.
The idea is we’re actually permeated by the chemicals flowing through our environment.
Our consciousness is shaped any time we eat anything.
Some drugs are not thought of as drugs: sugar, caffeine, tobacco.
These are accepted psychedelic substances.
The fact that cannabis and other psychedelics are becoming more mainstream again shows that we in late-stage capitalism.
Is there anything in particular you’ve been excited about in psychedelics lately?
The research on MDMA for PTSD in veterans coming back from Iraq and the success rate they’re achieving.
The FDA may be forced by the sheer weight of the evidence to approve MDMA.
The hope is that we can use MDMA to treat “pre-traumatic stress disorder.”
Enhance the empathic capacity of those who handle a great deal of conflict.
Within a year or two the FDA is going to be approving MDMA, which is unbelievable.
Joe and Matt talk about how credentials are often forced as a barrier to entry into certain fields.
Matt is all for a standardized approach to mainstream these things.
He wants to go in all directions to get the therapy out.
The plants used in psychedelics are so much safer than any drug that’s on the market right now.
Some lawmakers are trying to pass a law to allow the death penalty for drug dealers, including those who sell cannabis.
Do you have any places you’d like to send people to re-engage with philosophy?
Study the history of philosophy.
Passion of the Western Mind by Richard Tarnas.
Story of Philosophy by Will Durant
Matt teaches an online course on Whitehead, the next one begins in January 2019.
Philosophy is not an abstract linguistic analysis.
He approaches philosophy as a spiritual practice.
Philosophy is learning to die.
We’re embodied creatures and philosophy is a way to come to terms with that.
Psychedelics help you experience ego death, but we’re still conscious.
Tweetable Quotes
Psychedelics are not just theoretically interesting, they have profound practical implications for how we organize our lives.
Whitehead’s terminology is an attempt to return us to our concrete experience.
Matthew T. Segall, PhD, received his doctoral degree in 2016 from the Philosophy, Cosmology, and Consciousness program at CIIS. His dissertation was titled Cosmotheanthropic Imagination in the Post-Kantian Process Philosophy of Schelling and Whitehead. It grapples with the limits to knowledge of reality imposed by Kant’s transcendental form of philosophy and argues that Schelling and Whitehead’s process-oriented approach (described in his dissertation as a “descendental” form of philosophy) shows the way across the Kantian threshold to renewed experiential contact with reality. He teaches courses on German Idealism and process philosophy for the Philosophy, Cosmology, and Consciousness program at CIIS. He blogs regularly at footnotes2plato.com.
In this episode of Psychedelics Today, Kyle and Joe speak to Dennis McKenna (of Dennis McKenna fame) and Mark Plotkin founder of the Amazon Conservation Team. We discuss a broad range of subjects. One of the most interesting was a project that Dennis and many others have been working on for over a year at the time of recording this, titled Ethnopharmacologic Search for Psychoactive Drugs, which was a conference in the UK in 2017. It was a 50-year follow up to the initial event (and later seminal book) that Richard Evan Schultes, Ph.D. helped coordinate and host.
This link will take you to a page where you can see all of the talks that were given at ESPD50. https://vimeo.com/album/4766647
We really think you’ll enjoy the show. Please let us know what you think and if you can, pre-order the ESPD 50 to save some money on the post-release price.
“In 1967, a landmark symposium entitled Ethnopharmacologic Search for Psychoactive Drugs was held in San Francisco, California. It was the first international, interdisciplinary group of specialists – from ethnobotanists to neuroscientists – who gathered in one place to share their findings on the use of psychoactive plants in indigenous societies. Follow-up meetings were intended to be held every ten years, but the War on Drugs intervened. The findings of the convention were printed in a book entitled with the same name as the gathering.
On the 50th anniversary during the month of June 2017 an international group of specialists gathered again to share their perspectives on past, present, and future research in ethnopharmacology. The symposium was held at the spectacular Tyringham Hall in Britain.
ESPD50 was organized by a team led by Dennis McKenna, Founder of Symbio Life Sciences, PBC. Synergetic Press published a collector’s box set including the first edition of 1967 plus a brand new book with the 50th-anniversary symposium’s findings.”
Dr. Plotkin has led ACT and guided its vision since 1996, when he co-founded the organization with his fellow conservationist, Liliana Madrigal. He is a renowned ethnobotanist who has spent almost three decades studying traditional plant use with traditional healers of tropical America.
Dr. Plotkin has previously served as Research Associate in Ethnobotanical Conservation at the Botanical Museum of Harvard University; Director of Plant Conservation at the World Wildlife Fund; Vice President of Conservation International; and Research Associate at the Department of Botany of the Smithsonian Institution.
Among his many influential writings, Dr. Plotkin may be best known for his popular work Tales of a Shaman’s Apprentice (1994), which has been printed continuously and has been published in multiple languages. Other works include the critically acclaimed children’s book The Shaman’s Apprentice – A Tale of the Amazon Rainforest, illustrated by Lynne Cherry, and Medicine Quest: In Search of Nature’s Healing Secrets. His most recent book, The Killers Within: The Deadly Rise of Drug-Resistant Bacteria, coauthored with Michael Shnayerson, was selected as a Discover Magazine book of the year.
In 1998, he played a leading role in the Academy Award-nominated IMAX film Amazon. Dr. Plotkin’s work also has been featured in a PBS Nova documentary, in an Emmy-winning Fox TV documentary, on the NBC Nightly News and Today Show, CBS’ 48 Hours and in Life, Newsweek, Smithsonian, Elle, People, The New York Times, along with appearances on National Public Radio. Time magazine called him an “Environmental Hero for the Planet” (2001) and Smithsonian magazine hailed him as one of “35 Who Made a Difference” (2005), along with Bill Gates, Steven Spielberg, and fellow New Orleanian Wynton Marsalis.
Dr. Plotkin has received the San Diego Zoo Gold Medal for Conservation; the Roy Chapman Andrews Distinguished Explorer Award; an International Conservation Leadership Award from the Jane Goodall Institute; and, with Liliana Madrigal, the Skoll Foundation’s Award for Social Entrepreneurship. In 2010, he received the honorary degree of “Doctor of Humane Letters” from Lewis and Clark College in Portland, Oregon. Dr. Plotkin was educated at Harvard, Yale and Tufts University.
About the Amazon Conservation Team
The Amazon Conservation Team (ACT) is a non-profit organization dedicated to preserving South American rainforests. This small but robust outfit occupies a unique niche among other environmental non-profits working in the tropics: ACT works hand in hand with local indigenous communities to devise and implement its conservation strategies.
About Dennis McKenna
Dennis Jon McKenna is an American ethnopharmacologist, research pharmacognosist, lecturer, and author. He is a founding board member and the director of ethnopharmacology at the Heffter Research Institute, a non-profit organization concerned with the investigation of the potential therapeutic uses of psychedelic medicines.
McKenna received his Master’s degree in botany at the University of Hawaii in 1979. He received his doctorate in botanical sciences in 1984 from the University of British Columbia,[2] where he wrote a dissertation entitled Monoamine oxidase inhibitors in Amazonian hallucinogenic plants: ethnobotanical, phytochemical, and pharmacological investigations. McKenna then received post-doctoral research fellowships in the Laboratory of Clinical Pharmacology, National Institute of Mental Health, and in the Department of Neurology, Stanford University School of Medicine.
Malin Vedøy Uthaug is a Ph.D. candidate at Maastricht University and based out of Prague. Malin joins Psychedelics Today to talk about her interest and research with ayahuasca and 5-MeO-DMT. Malin shares her experience how she got involved studying psychedelics and shares a little bit about her personal experiences with ayahuasca. Malin is currently working on an interesting research study examining the potential influence that the ritual and ceremony may have on the overall ayahuasca experience.
Leave us a comment below and let us know what you think about this episode!
Seminar with Malin Uthaug on the effects of ayahuasca and 5-MeO-DMT
About Malin Vedøy Uthaug
Malin Uthaug received a B.A degree in Psychology from University of New York in Prague and Empire State College June 2016. She then pursued her master in Health and Social Psychology at Maastricht University in The Netherlands 2016/2017 and graduated August 2017. During her last semester of her Masters, Malin was on a research internship in Colombia whereby she did field research on Ayahuasca under the supervision of Dr. Jan Ramaekers from Maastricht University, and Dr. Jordi Riba from Sant Pau hospital in Barcelona. The research internship was part of her master thesis titled “The Long-term Effects of Ayahuasca on Affect and Creative Thinking”. Now, on the side of being a PhD candidate researching the effects of Ayahuasca and 5-MeO-DMT, she is a life coach and public speaker. She started her coaching project titled Love & Gratitude in September 2016 which serves as a platform to spread information related to positive psychology and transpersonal psychology. Love & Gratitude has also become a way to bring about information about psychedelics, and help destigmatizing them. She has since September 2016 delivered talks and workshops in Belgium, The Netherlands, Czech Republic, Norway, and Colombia.
Leonie Joubert, a science writer, author, trainer and public speaker, joins Kyle Buller and Joe Moore to discuss psychedelic policy in South Africa. We discuss the promising avenues of improving policy around mushrooms, iboga and more. We also learn about South Africa wanting to be more involved in the psychedelic movement including research and medicalization.
About Leonie Joubert
Leonie uses different storytelling approaches to wander through the often unmapped terrain faced by all of us as we find ways to live together on an ever more tightly packed planet: climate, energy, environmental change, and hunger and malnutrition in the world of Big Food. Mostly, her stories try to give voice to a silenced environment, and the social injustices of a society where the divide between rich and poor has never been greater.
She has spent the better part of 15 years exploring these topics through books, journalism, communication’s support to academics and civil society organisations, and non-fiction creative writing.
Bibliography
Scorched: South Africa’s Changing Climate
Boiling Point: People in a Changing Climate
Invaded: the Biological Invasion of South Africa
The Hungry Season: Feeding Southern Africa’s Cities
Oranjezicht City Farm: Food, Community, Connection
She has also contributed a few book chapters, including:
Opinion Pieces by South African Thought Leaders, edited by Max du Preez (Penguin, 2011)
Bending the Curve, edited by Robert Zipplies (Africa Geographic, 2008)
Climate Governance in Africa – A Handbook for Journalists (IPS Africa and HBF, 2014), contributed an article.
Dr. Ben Sessa is a writer, psychiatrist, and researcher working in the UK to start the first ever MDMA for alcohol addiction study. We have a very exciting discussion and even get Dr. Sessa’s first reaction to the idea of DMTx. We also explore Ben’s background and his experiences with psychedelics legally – Ben is one of the few people who has ever received MDMA, LSD, DMT, ketamine, and psilocybin in a legal research setting.
We hope you enjoy this episode! Leave a comment below and let us know what you think.
Dr. Ben Sessa, M.B.B.S., M.D., B.Sc., M.R.C.Psych., is a consultant child and adolescent psychiatrist working in adult addiction services and with custodial detained young people in a secure adolescent setting. He trained at UCL medical school, graduating in 1997. He is interested in the developmental trajectory from child maltreatment to adult mental health disorders. Dr Sessa is currently a senior research fellow at Bristol, Cardiff and Imperial College London Universities, where he is conducting the UK’s first clinical studies with MDMA-assisted therapy for the treatment of PTSD and alcohol dependence syndrome. In the last ten years he has worked on several UK-based human pharmacology trials as study doctor or as a healthy subject administering and receiving test doses of LSD, psilocybin, MDMA, DMT, and ketamine. He is the author of several dozen peer-reviewed articles in the mainstream medical press and has written two books exploring psychedelic medicine; The Psychedelic Renaissance (2012 and 2017) and To Fathom Hell or Soar Angelic (2015). In speaking publicly at universities and medical conferences, Dr Sessa is outspoken on lobbying for change in the current system by which drugs are classified in the UK, believing a more progressive policy of regulation would reduce the harms of recreational drug use and provide increased opportunities for clinical psychedelic research. He is a co-founder and director of the UK’s Breaking Convention conference.
James Casey, a student at Colorado University Boulder, joins us on Psychedelics Today to share his experience with MDMA-assisted psychotherapy, forming the Psychedelic Club Boulder, and his interest in neuroscience. James had the unique opportunity to be a research participant in the MAPS phase-2 MDMA-assisted psychotherapy for PTSD trials and shares part of his experience with us. The MDMA-assisted psychotherapy has been a life saver for James, and now he advocates for the therapeutic use of MDMA for treatment of PTSD and other mental health issues.
Episode Quote
I think it is criminal that we are really keeping this (MDMA-assisted psychotherapy) from people….. Veterans aren’t the only people suffering that need this (MDMA-assisted psychotherapy), people who have experienced childhood trauma, law enforcement, firefighters, people that are victims of rape, or gang violence. This really has the potential to heal so many people. To speak for the veteran community, I know so many people that I’ve deployed with or know that have been deployed, that I am afraid I am going to get a call tomorrow, next week, or next month because they killed themselves. To know that if they try to do the same treatment that I did outside of the MAPS study, that they risk getting thrown in a cage for years on end is criminal to me.
Show Notes
Researching the effects of LSA on cockroaches
Psychedelic Club Boulder
Tips on starting a psychedelic club/group
Drug testing on campus at CU Boulder
Results of testing – 88% of the MDMA samples tested positive for meth. About 40% of the LSD samples tested positive for a research chemical
Drug reform and war on drugs
Veterans, PTSD, and MDMA-assisted psychotherapy
Changing the psychedelic narrative among law enforcement
DMTx
About James Casey
U.S. Army veteran, participated in a study of MDMA-assisted psychotherapy for posttraumatic stress disorder (PTSD) in 2014. After three sessions of MDMA-assisted psychotherapy, James no longer qualifies for PTSD.
In this episode, Kyle and Joe talk CBD, ketamine, terpenes, floating, psychedelic education and much more! This conversation is a little different than our normal episodes, but we wanted to share some things that are going on here at Psychedelics Today, such as exploring our recent sponsorships for the show. Please let us know your thoughts about this! Our goal is to keep this podcast sustainable, as well as help promote those who are doing great work directly or indirectly with the psychedelic community.
If you enjoy the show and want to support in another way, donating to our Patreon is a great option!
Thanks for listening!
The Pharmacology of Cannabis Cannabinoids and Terpenes by Dr. Ethan Russo
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Navigating Psychedelics: Lessons on Self-Care & Integration
This is the third article in a series on psychedelic chemistry, and the final article focusing on the tryptamine class. In the previous article we learned that though DMT and 5-MeO-DMT lack oral activity, chemistry wizards are able to change that. By making one of a variety of simple alterations to their structure they may be changed into analogs (“research chemicals”, or RCs), each possessing their own unique subset of characteristics including oral activity. That’s because the chemists changed the three-dimensional configuration of the molecules in such a way that the lone pair of electrons situated on the amine’s nitrogen (Figure 1) became shielded, thereby preventing their degradation by MAO. To recap, if one consumes monoamines (such as certain tryptamines) orally, MAO transforms them in the gut and by the time they enter the bloodstream they are no longer psychoactive – Figure 2.
Figure 1. Nitrogen has 7 electrons in total, and 5 valence electrons. It has one electron in each of the three 2p orbitals, which allows it to make three bonds (green), and two electrons in the 2s orbital which exists as a lone electron pair (blue).
Figure 2. After 5-MeO-DMT is consumed orally (1) it enters the gut (2) and is transformed by MAO-A (3). MAO-A uses oxygen to convert the amine into a carboxylic acid (4). This converts 5-MeO-DMT into the nonpsychoactive 5-MIAA (5-methoxyindole-3-acetic acid), the species which enters the circulatory system (5)
This article is going to unpack a study (Figure 3) that showed, by comparing the structures of the naturally-occurring molecules psilocin and bufotenin why the former is orally active while the latter is not. This is another pioneering study from the lab of Dr. David Nichols, who is, along with Albert Hoffman and Sasha Shulgin, in my estimation one of the three true giants of psychedelic chemistry. Its his work and excellent lectures from ESPD50, Psychedelic Science (2013 and 2017), and Breaking Convention that restoked my appreciation for chemistry and inspired me to not only deepened my knowledge, but also to start this series of articles. The outpourings from his majestic mind has fundamentally shaped the topics and content of these articles… Shout out Big D, whut-whut!
Figure 3
The structure and atomic composition of a chemical are obviously critical to our understanding, and the progression of, chemistry and pharmacology. The problem with that is that molecules are small – really small. Even with today’s stupefying repertoire of advanced scientific analytical instruments, there is still no practical way for us to observe their structure directly. So instead we have devised sophisticated methods in which to do so indirectly. One of these methods is called Nuclear Magnetic Resonance (NMR) Spectroscopy, which uses information about the spin of atomic nuclei to determine what a compound’s structure looks like.
In 1980 the team at Purdue University used NMR spectroscopy to investigate how the three-dimensional structures of bufotenin and psilocybin differ from one another. Even though these two compounds are constitutional isomers (Box 1; Figure 4), there is a critical difference in their activity – psilocin is orally active, whereas bufotenin is not. This tiny change, moving the hydroxyl group from position 5 to 4 made this critical difference in the way they are absorbed by a human body. Though 2D-representations of the respective molecules are too low resolution to allude to the reason for the disparity, the researchers (correctly) suspected that by looking at their 3D-structures they would be able to understand why one molecule could resist deamination by MAO, while the other could not.
Figure 4. Bufotenin and psilocin are constitutional isomers, the only difference in their structure is the position of the hydroxyl group (-OH).
NMR spectroscopy revealed that the ethyl sidechain of bufotenin is able to rotate freely, meaning it can spin around on its own axis (Figure 5). That is however not the case for psilocin, something locks it in place, preventing it from rotating freely. The ethyl sidechains of the molecules are identical, which means that whatever is preventing the free rotation of psilocin’s ethyl sidechain is related to the hydroxyl group being situated at position 4, and not 5. To find out exactly what that was, the researchers used specialized software called LAOCN3. Before we explore what they found it would be useful to our interpretation of the results if we brushed up on a couple of elementary concepts in chemistry.
Figure 5
There are two basic types of bonds that atoms can form with one another. The first, called an ionic bond, forms when atoms exchange electrons with one another. This happens if the encountering atoms possess large differences in their respective affinities for electrons (called electronegativity), one atom really wants to lose an electron, while the other really wants to gain it (Figure 6). So an electron (or electrons) are exchanged, and because it is negatively charged the transfer changes the charge of the each atom. The atom that gains the electron gains a negative charge and thus becomes negative, while the atom that loses the electron loses a negative charge and thus becomes positive. And as the old adage goes, opposites attract – the oppositely-charged atoms come together and form a stable bond with one another.
Figure 6. Ionic bonds.
The other type of bond that can unite atoms is a covalent bond. This happens when atoms with similar affinity for electrons encounter one another, neither really wants to lose/gain an electron so they reach a compromise – they share their electrons among each other. Both atoms pretend that the electron that it shares, as well as the electron shared by the other atom, belongs to it (Figure 7). It’s this overlap of shared electrons that connects the atoms together into a single molecule.
Figure 7. Covalent bond.
Because there are no electrons that are transferred in the covalent bond the atoms don’t assume a charge as was the case with ionic bonds. However, that’s only partially true… In certain cases, the atoms that take part in a covalent bond do have some difference in their affinity – not enough for them to exchange electrons and form an ionic bond, but enough so that when they form a covalent bond and share electrons those shared electrons are closer to one atom than the other. This is known as a polar covalent bond. The atom to which the shared electrons are in closer proximity has a higher electronegativity and thus becomes partially negative (δ-). Conversely, the atoms with lower electronegativity are further from the shared electrons and are partially positive (δ+). Because of this asymmetrical charge, polar molecules are able to form weak bonds with other polar molecules, or with compounds that have a net charge. Now that we’ve covered some basic concepts let’s get back to the results of the study and apply what we’ve learned by taking a closer look at psilocin (Figure 8).
Figure 8. In the red area is a hydroxyl group (Figure 9), and in the blue area is a tertiary amine (Figure 10).
Figure 9. The electronegativity of hydrogen (white) is 2.1, while that of the oxygen (red) is 3.5. This difference of 1.4 in their electronegativity is not enough to form an ionic bond, but does lead to partial charges – oxygen has a higher affinity for electrons meaning the electrons are closer to it and assumes a partially negative charge (δ-), while hydrogen assumes a partially positive charge (δ+).
Figure 10. The tertiary amine group consists of a nitrogen (blue) with an electronegativity of 3.0, connected to three carbons (grey) each with an electronegativity of 2.5. Nitrogen has a higher affinity for electrons and pulls the electrons closer to it, leading to a partial negative charge (δ-), while the carbons have partial positive charges (δ+).
Taken together: psilocin has hydroxyl group at position 4 with a partially negative oxygen and a partially positive hydrogen, and an amine with a nitrogen that is partially negative and carbons that are partially positive. Because of these partial charges something interesting happens – the partially positive hydrogen from the hydroxyl group and the partially negative nitrogen from the amine attract one another (Figure 11).
Figure 11
The hydrogen and nitrogen form a special type of bond with one another known as hydrogen bond (Box 2) which pulls the two atoms closer to one another, changing the shape of the molecule – Figures 12 and 13.
Figure 12. The partial positive charge on the hydrogen and partial positive charge on the nitrogen (left) are attracted to one another and form a hydrogen bond which pulls the atoms closer to each other, changing the molecule’s shape (right).
Figure 13. The hydrogen of the hydroxyl-group is bent backwards into a gauche conformation while the ethyl tail bends towards the indole ring to further shorten the distance between them.
It’s this hydrogen bond that locks the ethyl sidechain into place by forming a closed loop (Figure 14), preventing it from rotating freely. In bufotenin the ethyl sidechain can rotate freely because no such hydrogen bond exists. Because the hydroxyl-group is at position 5 and not 4, the partially charged molecules are too far away from one another to form the hydrogen bond, change the shape of the molecule, and lock the ethyl sidechain into place.
Figure 14
But what has any of this to do with the difference in oral activity between the two molecules? Turns out, everything. It’s this hydrogen bond and closed loop formation in psilocin which shields the lone pair of electrons situated on the nitrogen. Because MAO cannot access the electrons it cannot deaminate the molecule – this is why it can pass through the gastrointestinal system unchanged.
But there’s more. The hydrogen bond and resulting closed loop formation also lead to several other important changes in the property of the molecule which further accentuates its efficacy and potency as an orally-active psychedelic tryptamine. After generating 3D-models of the respective molecules, the researchers went on to compare their pKa (Box 3) and Log P (Box 4) values..
When they measured the pKa and the Log P for both psilocin and bufotenin they found the following:
The pKa for Bufotenin is 9.67, meaning that at that specific pH-value equal amounts of the molecule will be present in both the ionized (water soluble) and protonated forms (lipid soluble). When the molecule is in the blood, which has a pH of about 7.4, almost all of it (99.5%) is in the ionized form. In contrast, psilocin has a pKa of 8.47, closer to the pH of blood. So for psilocin, only about 52% is in the ionized form. That means that in the blood, 48% of psilocin will be in its unionized form versus only about 0.5% when it comes to bufotenin. As it is only the unionized form of the drug that can cross cell-membranes, this has profound implications for the potency of these two drugs – psilocin is not only able to better withstand degradation by MAO, but once it is in the blood there is also much more of it available in a form that can cross cellular membranes and thus can reach the target receptors and exert an effect.
The difference in pKa is also related to the shielding of the electron lone pair by the hydrogen bond. As we have learned, amines possess a nitrogen with a lone pair of electrons. These free electrons, which carry a negative charge, are all too happy to snap up positively-charged protons (H+) from a solution they are in. This is, according to the Bronsted-Lowry acid-base theory, the very definition of a base – something that accepts protons. When it comes to psilocin the lone pair of electrons are shielded and are thus much less likely to accept protons. As a consequence, psilocin is less basic that is bufotenin.
The researchers also detected a difference in the Log P values – 1.19 for bufotenin, and 1.45 for psilocin. In the Log P scale a negative value indicates a compound which is hydrophilic, whereas a positive value indicates one that is lipophilic. Both these compounds are thus lipophilic, and psilocin, with the higher value, is more lipophilic. For drugs, in general, it is preferable for them to be lipophilic so as to be able to cross cell membranes, but not too lipophilic because then they immediately migrate to, and are stored in, the body fat. Research indicates that a Log P value of about 3.0 is the “sweet spot”, so psilocin is closer to this number, again indicating that its properties are more favourable once it enters the body.
The researchers started with a simple question: how is it that two isomeric compounds with such a small difference have such widely different properties when they are consumed orally? With NMR Spectroscopy we learned that it all has to do with the fact that because the hydroxyl group of psilocin is a little bit closer to the amine it was able to form a hydrogen bond between the two groups. This hydrogen bond shields the electron lone pair from deamination by MAO, which means that, unlike bufotenin, psilocin is orally active. The hydrogen bond also decreases the molecule’s proton-accepting capacity thereby decreasing its pKa value which means that at blood pH there is more of psilocin in the non-ionized (lipid soluble) form which is able to cross cell membranes and thus enter the central nervous system (CNS). Finally, we saw that it also affected the Log P value, and that psilocin is a more lipophilic compound, closer to an ideal value for drugs to effectively enter and bind to the appropriate receptors in the CNS.
I hope you enjoyed this journey, in the next article we will start our exploration of the phenethylamine class.
Faan Rossouw was born and raised in Cape Town (South Africa) and currently resides in Montreal (Canada). He holds a MSc in Plant Science, and is the co-founder and Chief Strategy Officer of Indeeva Biomedical, a medical cannabis company that focuses on producing condition-specific cannabinoid therapeutics. Faan possesses theoretical expertise and practical experience in biological production systems, natural and pharmaceutical product development, phytochemistry, and psychopharmacology. Though his background is rooted in science he is most passionate about, and thrives in, the intersection of science, the humanities, and commerce. He is interested in how we can leverage the properties of the new global economy to develop superior and sustainable therapeutic solutions. In his free time he loves to practice Brazilian Jiu Jitsu, spend time in nature with his partner Robyn, or kick back in his lazy boy with a book, a cup of pu-erh tea and his cat Luna.
Caitlin Thompson, the founder of EntheoZen, joins us on Psychedelics Today to share her healing story, her interests in psychedelics, and the supplement company that she started. Caitlin is also involved in the psychedelic community – she hosts events for the Aware Project San Diego and is a Kambo practitioner.
After struggling with her own depression and anxiety, Caitlin founded EntheoZen. She applied her background in neuroscience, diving deep into the scientific literature and discovered the importance of nutrition in brain and mood health. She created a scientifically-supported line of products that nourish, resource and balance the nervous system to promote a happy, healthy mind.
Caitlin uses EntheoZen as a platform to provide informative resources and tools to empower people to take their mental wellness into their own hands in a natural and sustainable way. EntheoZen provides educational media on cutting-edge wellness modalities including nutrition, herbs, meditation, psychedelics, neurofeedback training, kambo, and float tanks. Caitlin is a researcher and advocate in the psychedelic medicine movement, using EntheoZen to support research and promote awareness of psychedelic therapies as effective psychiatric interventions.
EntheoZen is a nutritional supplement company based in San Diego, CA. It was launched in 2014 by Caitlin Thompson. At EntheoZen, our goal is to contribute to the practice of using safe and natural ways to balance brain chemistry and promote brain health and a happy mood. Blending neuroscience and holistic nutrition, we believe that the mind, body, and soul need the proper resources to stay balanced and lively. Our products are based on proven scientific principles and target specific mechanisms & issues related to mood disorders based on scientific literature. When the brain has access to the raw materials it needs to repair and function optimally, it can often heal and regulate itself.
About TransZen
TransZen is an all natural mood enhancement and stress support supplement designed to:
-fill in nutritional gaps that may be causing low mood
-promote neurotransmitter production such as serotonin and dopamine
-maintain a healthy inflammatory response in the brain
-promote the repair and regeneration of brain cells.
-It consists of 17 scientifically-studied ingredients including vitamins, minerals, amino acids and potent plant extracts.
-Works by providing your body with the raw materials it needs to balance the nervous system.
-It is made in a USA facility that is certified by the FDA as having Good Manufacturing Practices (GMP) and third-party tested.
After struggling with her own battle with depression and anxiety, Caitlin Thompson applied her background in neurobiology and dove into the cutting edge scientific literature on mood disorders and mental illnesses. This led her down a health rabbit hole, realizing that Lyme disease, small intestinal bacterial overgrowth, microbiome dysbiosis and emotional trauma were at the root of her and many others’ depression. After successfully improving her own health, Caitlin founded her nutritional supplement company, EntheoZen in 2014. Caitlin now uses EntheoZen as a platform to spread information about modalities and tools to empower others to heal and achieve optimal mental wellness. Caitlin also works in the psychedelic field advocating for psychedelic research and education around their implications in mental wellness and autoimmune conditions. Caitlin is also a certified Kambo frog medicine practitioner based in San Diego CA.
This is the second article in a series on psychedelic chemistry. In the previous article, I introduced the tryptamine class of psychedelics, and we discussed five well-known examples: DMT, 5-MeO-DMT, bufotenine, psilocybin, and psilocin. While the latter two, primary psychedelic constituents of Psilocybe mushrooms (Figure 1), are orally active, neither DMT, 5-MeO-DMT, nor bufotenine are. In this article we will explore two types of alterations that synthetic chemists can make to those molecules to bestow oral activity upon them. These alterations lead to the psychedelic tryptamine analogs (“research chemicals”): AMT (Indopan), MiPT, DiPT, 5-MeO-aMT (Alpha-O), 5-MeO-MiPT (Moxy), and 5-MeO-DiPT (Foxy Methoxy).
Figure 1
Monoamine Oxidase
L-monoamine oxidase (MAO) is a family of enzymes that catalyze the oxidation of monoamines. Monoamines contain a single amine connected to an aromatic ring via a 2-carbon chain, and include neurotransmitters such as serotonin and norepinephrine, as well tryptamines (Figure 2) such as DMT, 5-MeO-DMT, and bufotenin. The reason therefore that these compounds are not active after being consuming orally is because once they enter one’s gut they are inactivated by MAO.
Figure 2
If you want to experience the psychedelic effects of these compounds there are two basic strategies. The first is to use a route of administration that bypasses the gut. Smoking and vaporizing are by far the most common ways to achieve this, but are also the most intense (rapid onset) and shortest-lasting methods. Accordingly, some people favour other non-oral routes such as sublingual (under the tongue), insufflation (in the nasal passage), and rectal administration. Each of these administration routes has its own set of unique pharmacokinetic properties that may be favoured by certain people depending on the context and/or intention. Different strokes for different folks.
But that applies equally to oral delivery, which is unsurpassed in terms of its simplicity (swallow and then you’re done), ease (no thumbing around the butthole or snorting fiery salts up your schnoz), and duration. Except for transdermal delivery, which is technologically complex and has severe restrictions on what can be administered, oral delivery is the longest lasting. Hence its popularity for journeyers that wish to go in deep. So even with a number of non-oral administration routes available, there is still good reason to utilize the oral route.
How to do so if we all walk around with an enzyme in our belly that will deactivate the psychedelic? Simple – consume another compound, called a monoamine oxidase inhibitor (MAOI), that will deactivate that enzyme. Ayahuasca is a prime example of this, though there are a number idiosyncratic formulas of the brew, in essence, it is based on two core ingredients (Figure 3). One contains DMT, the most common being chacruna (Psychotria viridis), and the other contains the MAOI, which is always the ayahuasca vine (Banisteriopsis caapi).
Figure 3. A pot filled with chacruna leaves containing DMT, as well woody material from the ayahuasca vine containing harmine, tetrahydroharmine, and harmaline (MAOI’s). The former provides the visionary punch, the latter ensures that DMT is not broken down in the gut and is able to enter the blood plasma unchanged.
Synthetic chemists love to ask “what if” questions. Like “what if” I make this simple change to the molecular nature of the compound, how does that then affect its properties? These type of questions are explored not only in the name of scientific curiosity, but also because studying how simple changes affect the properties of compounds informs us about its structure-activity relationship, as well provide intimations of what the target receptor looks and behaves like. To the specific question of whether or not a simple alteration to DMT/5-MeO-DMT can actuate oral activity chemists have thus far provided two answers – α-methylation (Figure 4) and N-alkylation (Figure 6).
α-Methylation
Figure 4
As we covered previously, DMT is a tryptamine molecule with two methyls at the N-position. So what would happen if, instead of adding two methyls to the N-position of the tryptamine, we added a single methyl to the alpha-position? This yields AMT (alpha-methyltryptamine; Figure 5), a molecule originally developed in the ‘60s by a Michigan-based pharmaceutical company called Upjohn and which was prescribed in the USSR as an antidepressant. It is at once psychedelic, entactogenic (like MDA/MDMA), and a stimulant with an oral dose typically lasting upwards of 12 hours.
Figure 5
The same goes for 5-MeO-tryptamine (mexamine) – if instead of adding two methyls to the N-position to form 5-MeO-DMT we add a single methyl to the alpha-position, we get 5-MeO-AMT – 5-methoxy-alpha-methyltryptamine (Figure 5). This orally-active and potent psychedelic, commonly known as ‘Alpha-O’, is sometimes peddled as faux-LSD. This is problematic as, unlike LSD with no known lethal toxicity, 5-MeO-AMT has lead to deaths at fairly low doses. It’s not a War on Drugs, it’s a War on People.
With both AMT and 5-MeO-AMT there is a chiral centre at the alpha-position. Attaching a single methyl to the alpha position potentially yields either an S- or R-configuration. Both are psychoactive, both orally active, but work by Dr. David Nichols lab has found that the S-enantiomer is more potent.
N-Alkylation
Figure 6
With N-alkylation we manipulate DMT and 5-MeO-DMT as the departure point to realize oral activity. Both these molecules possess two methyls on the amine nitrogen. Work again by Dr. Nichols’ lab has found that if you replace one, or both, these methyls with isopropyl, the molecule becomes orally active (Figure 7).
Figure 7
In the case of DMT, if a single methyl is replaced by an isopropyl it results in MiPT (N-methyl-N-isopropyltryptamine), an obscure psychedelic with indistinct effects first introduced to the world in TiHKAL. In the case of 5-MeO-DMT, the same single substitution results in 5-MeO-MiPT (5-methoxy-N-methyl-N-isopropyltryptamine). Commonly known as “Moxy”, it is an extremely potent (4 to 6 mg p.o.) psychedelic with stimulating properties.
As my articles on chemistry are intended for the general reader, I just want to take a brief moment here to remind you that the reason I always write out the substitutive name of each compound is because it describes the actual molecule. If we know the substitutive name, we can draw the molecule, and vice-versa. Let’s briefly review this by using Moxy as an example (Figure 8), but please feel free to skip over to the next paragraph if this is old news for you by now. Starting from back we have tryptamine, so our “foundational” structure is an indole ring with an ethylchain at 3 which connects to an amine group (blue). Then we start from the front – at position 5 we have a methoxygroup (green), at N1 we have a methyl (fuschia), and then at N2 we have an isopropyl (red).
Figure 8
If both methyls are substituted by isopropyl, in the case of DMT the result is DiPT (N,N-diisopropyltryptamine), another bizarre creation of Sasha that primarily produces audial distortions. With 5-MeO-DMT the double substitution leads to 5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine) which likely has the most endearing street name of any psychedelic – “foxy methoxy”. Note that in both cases, though making the additional isopropyl substitution retains oral activity, it decreases potency.
What’s Going On Here?
So why is it that in both the case of DMT and 5-MeO-DMT replacing a methyl with a slightly larger and more complex compound makes it impervious to deamination by MAO thereby giving it oral activity? To give us a clue we need to look at the nitrogen in the amine group – Figure 9. In order for MAO to deaminate a molecule, it needs to access the lone electron pair of electrons (blue) on the nitrogen. A change in the molecule, such as substituting functional groups, changes its 3D-conformation. In the case of substituting a methyl with an isopropyl group on the amine, it changes the molecule’s 3D shape in such a way that shields the lone pair of electrons from MAO, thus giving it oral activity.
Figure 9. Nitrogen has 7 electrons in total, and 5 valence electrons. It has one electron in each of the three 2p orbitals, which allow it to make three bonds (green), and two electrons in the 2s orbital which exists as a lone electron pair (blue).
How do we know this is the case that it’s the molecule’s 3D shape that protects the lone pair from attack by the MAO and thus allows it to retain oral activity? Earlier in this article, I said that MAO breaks down tryptamines. We then spoke about DMT and 5-MeO-DMT, but what about psilocybin and psilocin? They are naturally-occurring tryptamines, yet they are also orally active – how so? Pioneering work by Dr. David Nichols in the ‘80s using NMR spectroscopy showed that the fact that psilocin has a substitution at position 4 and not 5 (as with DMT/5-MeO-DMT) causes a critical change in the molecule’s 3D structure which ensures the compound is orally active. This study and all the profound implications for psychedelic chemistry gleamed from it will be the topic of our next article.
Afterword:
If it is your intention to consume DMT, and especially 5-MeO-DMT, orally by combining it with an MAOI please do your homework. And once you’ve done your calculations, double-check them. Terence McKenna used to quip that the only real danger with DMT is “death by astonishment”. Though that is the case for smoking it, overdoing orally-administered DMT/5-MeO-DMT can lead to serotonin shock, convulsions, and in some cases, death. The Psychedelic Ship is leaving the harbour, please don’t drop any cannonballs on the deck.
About the Author
Faan Rossouw was born and raised in Cape Town (South Africa) and currently resides in Montreal (Canada). He holds a MSc in Plant Science, and is the co-founder and Chief Strategy Officer of Indeeva Biomedical, a medical cannabis company that focuses on producing condition-specific cannabinoid therapeutics. Faan possesses theoretical expertise and practical experience in biological production systems, natural and pharmaceutical product development, phytochemistry, and psychopharmacology. Though his background is rooted in science he is most passionate about, and thrives in, the intersection of science, the humanities, and commerce. He is interested in how we can leverage the properties of the new global economy to develop superior and sustainable therapeutic solutions. In his free time he loves to practice Brazilian Jiu Jitsu, spend time in nature with his partner Robyn, or kick back in his lazy boy with a book, a cup of pu-erh tea and his cat Luna.
The ensuing series of articles are intended for the general reader that, like myself, have an appreciation for the beauty of chemistry, and/or desire to learn more about it. That being the case I am going to be pedantic throughout the articles, deconstructing technical terms and “dirty pictures”* with the assumption that you do not know what they mean. That way we can learn them as we go along. If you are already fluent in Chemistrian, it goes without saying that you are free to skip over these and peruse selectively. This first article is an introductory exploration of the tryptamine class, and will be followed by further forays into other interesting aspects related specifically to this class before I move on to the others. Enjoy.
The Three Main Classes of Psychedelics
There are three classes to which most psychedelic compounds belong – the tryptamines, phenethylamines, and ergolines (Figure 1). The tryptamines include most of the well-known naturally-occurring psychedelics, including compounds derived from entheogenic fungi (psilocybin and psilocin), DMT, 5-MeO-DMT, bufotenin, and ibogaine. Mescaline is the only common naturally-occurring phenylethylamine, yet the class includes numerous well-known synthetic compounds such as MDMA and the 2-C’s. Ergolines most notable representatives include the naturally-occurring LSA and the semi-synthetic compound that turned on a generation, LSD.
Figure 1. Notable psychedelic tryptamines include (from top right): 5-MeO-DMT and bufotenin (Bufo alvarius), psilocybin and psilocin (Psilocybe mushrooms), ibogaine (Tabernanthe iboga), DMT (Chacruna viridis), and various analogs including: 4-HO-MET (pictured), 5-MeO-DiPT, DPT, MET, and 4-AcO-DMT. Notable phenethylamines include (from top left): Mescaline (Peyote), the 2C’s (Inventor Sasha Shulgin pictured), MDMA (MAPS logo), and a wide range of analogs including: Bromo-DragonFLY (pictured), DOM, DOI, and NBOMe. Notable ergolines include (from top): LSD, LSA (Ipomoea sp), and various analogs including: AL-LAD (pictured), ALD-52, and 1-P-LSD.
Tryptamines
Psychedelics of this class are all derived from tryptamine (Figure 2), a ubiquitous endogenous ligand and agonist of the human trace amine-associated receptor 1 (TAAR1). The name tryptamine is derived from its structural similarity to l-tryptophan (Figure 3), an essential amino acid and the precursor to both serotonin and melatonin.
Figure 2. Tryptamine consists of an indole ring connected to an amine through an ethyl attached to position 3.
Figure 3. L-tryptophan
Substituted Tryptamines
Although the “template” for psychedelics tryptamines is the molecule with all the various positions presented in Figure 2, in actuality, there are limitations to how this manifests in psychedelic compounds. This is either because certain modifications are either difficult to impossible, or they lead to inactive compounds. An example of this is if something is attached to position 2 (Figure 2) the compound becomes a serotonin-2A receptor antagonist therefor losing its psychoactivity. Based on these restrictions we can simplify the template presented in Figure 2 to Figure 4, which is called the ‘substituted tryptamine’. The three main changes that synthetic chemists can make to derive psychedelic analogs is derived from this figure.
Figure 4
First, one can add side chains to either position 4 or 5, and those side chains have to contain an oxygen molecule. We can confirm this by looking at all the well-known psychedelic compounds that have side chains attached to the ring – bufotenine has a hydroxyl (OH) group at position 5, 5-MeO-DMT has a methoxy (O-CH3) at position 5, psilocin has a hydroxyl (OH) group at position 4, and psilocybin has a phosphoryloxy (OPO3H2) at position 4. All at position 4 or 5, all with an oxygen included.
The second major change that can be made is a substitution at the α-position. Chemists can methylate (add a methyl group) the alpha-position to change a non-orally active species into one with orally active. We will explore this in full detail in the next article.
The final feasible change is adding sidechains to positions N1 or N2. All five of the major naturally-occurring species we have discussed thus far possess methyls at both positions (hence “dimethyl” from which the DM in DMT is derived – more below). These methyls may be substituted with more complex alkyls, another way in which chemists can turn non-orally active tryptamines into orally active species.
Psychedelics Tryptamines
Now that we have an idea of the chemical “archetype” of tryptamine psychedelics and the possible changes chemists can make, let’s have a look at the five most well-known naturally-occurring examples: DMT, 5-MeO-DMT, bufotenin, psilocybin, and psilocin.
DMT
The substitutive name for DMT is N,N-dimethyltryptamine. One of the most magical parts of learning chemical language is that from it one can deduce what they actual molecule looks like, and vice-versa. Let’s explore that using DMT as an example. Starting from the back we have tryptamine (blue), so we know that is the foundation of our molecule – the indole ring with an ethyl in position 3 attaching to an amine. Then we have “dimethyl” (red), meaning two methyls. Okay so now we know it’s the tryptamine molecule that has two methyls added to it. And where are these two methyls? They’re both positioned on the nitrogen of the amine, hence ‘N,N’.
Figure 5
What’s interesting about N,N-dimethyltryptamine is that it forms the foundation for all four other compounds we are going to discuss. In other words, all four of them are N,N-DMT with a little something extra. We can see that because the term is contained within the substitutive name of all four other molecules. Let’s have a look.
5-MeO-DMT
The substitutive name for 5-MeO-DMT is 5-methoxy-N,N-dimethyltryptamine (Figure 6). We can see that it has the whole name of DMT in it, so when we draw it we know we can start with that molecule – a tryptamine with two methyls on the amine (red and blue). What’s left is ‘5-methoxy’, which means that at position 5 we have a methoxy (green). A methoxy is a combination of a methyl and an oxygen – hence the name.
Figure 6
Bufotenin
The substitutive name for bufotenin is 5-hydroxy-N,N-dimethyltryptamine (Figure 7). As was the case with 5-MeO-DMT, the molecule has DMT as a starting point (red and blue). But this time, instead of a methoxy at position five, we have a hydroxy, -OH (green).
Figure 7
Psilocin
The substitutive name for psilocin is 4-hydroxy-N,N-dimethyltryptamine (Figure 8). Same story, it starts with the structure of DMT (red and blue). If we compare them, we can see the psilocin is extremely similar to bufotenin, the only difference being where bufotenin had the hydroxy at position 5, here it’s at position 4 (green). In a future article we will learn why this small change is crucial to ensure that psilocin, unlike bufotenin, is an orally active species.
Figure 8
Psilocybin
The substitutive name for psilocybin is 4-phosphoryloxy-N,N-dimethyltryptamine (Figure 9). By now I’m sure you’ve grokked it – it’s a DMT molecule (red and blue) with a little something extra. As with it’s cousin psilocin, that something extra is at position 4, but here instead of a hydroxy, it’s a phosphoryloxy with the composition OPO3H2 (green).
Figure 9
All five molecules and their substitutions are reviewed in Figure 10 below.
Figure 10
In the next article, we will continue to explore psychedelic tryptamine chemistry by looking at the two changes synthetic chemists can make to DMT and 5-MeO-DMT to make them orally active.
* = Sasha Shulgin used to affectionately refer to organic molecule structures as “dirty pictures”.
About the Author
Faan Rossouw was born and raised in Cape Town (South Africa) and currently resides in Montreal (Canada). He holds a MSc in Plant Science, and is the co-founder and Chief Strategy Officer of Indeeva Biomedical, a medical cannabis company that focuses on producing condition-specific cannabinoid therapeutics. Faan possesses theoretical expertise and practical experience in biological production systems, natural and pharmaceutical product development, phytochemistry, and psychopharmacology. Though his background is rooted in science he is most passionate about, and thrives in, the intersection of science, the humanities, and commerce. He is interested in how we can leverage the properties of the new global economy to develop superior and sustainable therapeutic solutions. In his free time he loves to practice Brazilian Jiu Jitsu, spend time in nature with his partner Robyn, or kick back in his lazy boy with a book, a cup of pu-erh tea and his cat Luna.
The use of heroin and abuse of opiate pain-relievers has reached an all-time high in the USA. The addictive nature of these drugs has left us scrambling for treatment options that can offer us freedom from this epidemic.
The fact is, traditional treatments don’t work for everyone, and many are starting to look for more effective alternatives. Treatment that results in long-lasting sobriety is different for each individual.
When a traditional method isn’t working, it may be time to consider something new. Ibogaine is one such treatment, and the rise in opiate addiction has led to an increased interest in this alternative treatment for opiate and heroin addiction.
Iboga and Ibogaine
Ibogaine is just one of the many alkaloids found in the Tabernanthe Iboga shrub. Raw Iboga is one of the most powerful psychedelic plants in the world and has been used for its profound spiritual effect on those who experience it.
This is why, for centuries, the Bwiti religion of Africa have been using Iboga as a way to induce introspection and a higher self-awareness.
In the early 1900s Ibogaine was extracted from the Iboga root and used by athletes, in very small doses, as a stimulant. At the time, Ibogaine was used because of the way that it excites certain pathways within the brain.
But in the 1960s, all of that changed.
Ibogaine as an Addiction Treatment
Howard Lotsof was suffering from an addiction to heroin when he tried Ibogaine for the first time in 1962. He was 19 years old and experimenting with any substance he could find.
Hours after trying the Ibogaine, Lotsof had an epiphany—he had not taken opiates for almost a day, yet, he had no withdrawal symptoms.
He waited, but the withdrawals never came.
Ibogaine had allowed Lotsof to break his heroin addiction with just one dose. He knew immediately that these implications could have a massive impact on others who were struggling with heroin and opiate addiction.
But, given the importance of this conclusion, Lotsof realized he needed to perform further testing. So, he rounded up a few of his opiate and heroin-addicted friends, gave them the Ibogaine, and the results were stunning—none of his friends went into withdrawal.
This was the beginning of Ibogaine treatment for addiction. As Lotsof introduced more and more studies on the effects of Ibogaine on withdrawal, it became a real point of interest for scientists who were looking for more effective ways to help addicts beat their dependence.
Unfortunately, this also came at a time when the US government began making psychoactive substances illegal. Ibogaine was classified as a Schedule 1 drug, putting it in the same class as the drugs that it was meant to treat. It also made it very difficult for scientists to study its positive effects on addiction.
Lotsof was forced to study Ibogaine and treat addicts in Europe, where he founded the Global Ibogaine Therapy Alliance. He worked hard to try and change the laws in the USA and other countries, but, unfortunately, lacked the resources he considered necessary to do so.
Ibogaine has a unique effect on the chemical levels in the brain.
When the addict begins using opiates, these drugs release massive quantities of chemicals that plug into the brain’s neurotransmitters.
The brain becomes addicted to these high levels of pleasure-inducing chemicals, changing the way that the brain would normally function.
Because of these addictive adaptations, when the supply of drugs is cut off, the brain goes into a frenzy. Depression, seizures, and other symptoms are often the result. This is what we call withdrawal.
Ibogaine has the ability to work on the chemical receptors in the brain. It repairs neurons in the brain that have been damaged due to opioid addiction. It also restores balance to the brain so that naturally produced chemicals can work properly to control feelings of pleasure and happiness.
This gives addicts a fresh start, and the ability to start focusing on changing their lifestyle, instead of just fighting withdrawals.
But Ibogaine doesn’t just treat the withdrawal symptoms, it also affects the brain on a psychological level.
Psychological Effects of Ibogaine
In many addicts, though not all, Ibogaine induces a dreamlike state.
Those who have experienced this state often say that Ibogaine made them face their fears, past traumas, and helped them conquer many of the underlying reasons that caused their addiction in the first place.
This kind of psychological clarity and introspection is unique to the effects of Ibogaine and psychedelic medicines.
This is also why Ibogaine has been recommended, by some, as a treatment for trauma and other mental conditions—such as depression, anxiety, and PTSD.
The psychedelic effects of Ibogaine have the ability to treat these mental issues in ways that therapy never could. Some describe it as taking a look at themselves from the outside in, finally being able to address the core of their problems and address the root cause.
Is Ibogaine Right for You?
Just like any other treatment method, Ibogaine requires close supervision from medical professionals. Because of the way Ibogaine reacts in the body, it can be dangerous. This is why it is recommended that Ibogaine treatment should be done in a medical setting.
Addiction is a deeply personal disease and one that requires a different type of treatment for every individual. Ibogaine is not for everyone. It’s important to look into all of your options and talk to your physician.
Sobriety is possible. Every individual deserves a happy and successful life. Take the time to study all of the treatment options available and make the right decision for you or your loved one.
About the Author
Aeden Smith-Ahearn was a massive heroin addict for 7 years. After trying every traditional treatment method available, he put his last hop into Ibogaine treatment. Now, he has been clean and sober for 5 years while also helping thousands of addicts find freedom through Ibogaine. He is currently the treatment coordinator for Experience Ibogaine treatment centers and works hard every day to help people find success and happiness in life.
Dr. Scott Shannon joins Psychedelics Today to share his experience and insights about ketamine therapy used in conjunction with integrative psychiatry. Dr. Shannon has been working with ketamine for the past year within his psychiatry practice and has found tremendous benefit in using this medicine for particular disorders. Dr. Shannon is also part of the Fort Collins MAPS MDMA-assisted psychotherapy Phase 3 study, which is just starting up.
Show Topics/Notes
What is ketamine?
Mechanisms of action of ketamine.
What is the ketamine experience like?
Three types of administration methods – IV, IM, and oral
MDMA-assisted psychotherapy and the MAPS Phase 3 trials
Transpersonal experiences fostering change and transformation
Critiques of traditional psychiatry.
Patient with 40 years of depression became a new person no longer suffering from depression.
Electro Convulsive Therapy was almost an option, thankfully avoided.
The importance of music with ketamine therapy and other psychedelics
Scott Shannon: Cannabidiol in the Treatment of Anxiety
I decided to become a psychiatrist in high school after my first psychology class. The amazing capacity of the human mind simply astounded me. I wanted to help people by using this power of the mind. What intrigued me the most then (and now) is that our human potential remains only partially understood. I am still on that journey of discovery about our true potential. To this end, I resonate with the theme of empowerment: my greatest day is the day that you have the skills to thrive without my services.
I feel blessed with all that I have been given in my life. I have been married for almost thirty years to Suze with two wonderful children, Noah and Sarah. I love to travel the world teaching or just exploring. My nature is relentlessly creative and curious. I love to cycle, snowboard, golf, run, climb, backpack and listen to music. Seamus, my big black Lab, may accidentally show up to work with me occasionally just because he likes people so much. My spiritual life is very important to me and I have meditated for over thirty years. Helping people makes my heart sing.
As a child and adolescent psychiatrist, my current focus involves supporting young people to find wholeness and recover their full health in body, mind and spirit. Although I use prescription medication at times, I much prefer to employ natural methods like nutrition, supplements, mind-body skills, acupuncture and a shift in awareness to support the healing process. This approach represents the new field of Integrative Psychiatry. Most importantly, I employ a holistic philosophy to understand people and their struggles. The single most important thing that I have learned in my professional life is to listen well: deeply and intuitively. After this listening, much of my work involves teaching you what I have heard. I founded Wholeness Center to work in collaboration with a team of gifted healers to help you better understand your story.
College: University of Arizona
Medical School: University of Arizona
Internship: Columbia Program, Cooperstown, NY
Psychiatric Residency: Columbia Program, Cooperstown, NY
Child/Adolescent Psychiatry Fellowship: University of New Mexico
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Download Emanuel Sferios joins us to talk about his upcoming film “MDMA The Movie” along with the founding story of Dance Safe.
Emanuel has a fascinating story that includes.
Humble beginnings
Lots of media attention
Huge amounts of fundraising for harm reduction
A film that is going to be incredible. Check out the trailers below!
MDMA was one of the last drugs that the old guard anti drug US government worked to smear with disinformation and outright lies, using outlets like Oprah and more to stain MDMA’s reputation. While Ophra’s media empire has now come around a bit, MDMA continues to hold parts of the social stigma that Oprah helped to give it. Emanuel tells the story here with on the ground details in ways that Kyle and Joe haven’t heard before.
We hope you love it!
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Want to learn more about psychedelic harm reduction, safety, and integration? Sign up for our online course!
Find MDMA The Movie On Social Media
About Emanuel Sferios
Emanuel Sferios is an activist, educator, public speaker and harm reduction advocate. Founding DanceSafe in 1998, Emanuel was an early pioneer of MDMA harm reduction. DanceSafe has volunteer chapters in over two dozen cities across the United States and provides non-judgmental, peer-based drug education and drug checking (a.k.a., “pill testing”) services in the electronic dance music community. Emanuel also started the first public laboratory pill analysis program in 1999 which allowed ecstasy users for the first time to anonymously send tablets to a DEA-licensed laboratory for chromatography analysis. Originally publishing the results on the DanceSafe website, the program still exists today and is hosted at Ecstasydata.org.
Today Emanuel speaks at colleges and universities about MDMA, harm reduction, and drug policy. He lives in Grass Valley, California with his wife and two stepchildren.
Download Rafael Lancelotta, the administrator of the site, 5meodmt.org (5 Hive), joins us to talk about the powerful psychedelic compound, 5-MeO-DMT. Some of you may have heard of this medicine, but if you have not, chances are you will begin hearing about it more and more. 5-MeO-DMT is a powerful psychedelic medicine that comes from venom secretion of the Bufo Alvarius toad. This compound is also found in various plants as well.
Correction – 5-MeO-DMT has an oxygen and a methyl group attached to it, not just an oxygen.
Show Topics
What is 5-MeO-DMT
How does it differ from N.N-DMT?
Near-death experiences and DMT
Dr. David Nichols talking about DMT at Breaking Conventions
Rafael Lancelotta is a graduate student at the University of Wyoming studying Mental Health Counseling. He is interested in the use of psychedelics towards greater levels of resiliency, mental health, and openness. He is also interested in the investigation of techniques used in the counseling relationship that may deepen and enhance the benefits of psychedelic-assisted therapy integration. He is passionate about opening the doors to psychedelic research to all students that are interested as well as helping to raise awareness as to the responsible clinical applications of psychedelics/entheogens and serves as the administrative assistant for the Source Research Foundation. He hopes to continue on to a PhD to help develop evidence-based practices for psychedelic-assisted therapy integration to empower individuals to make lasting positive change in their lives and in their communities. He is also the administrator of 5meodmt.org, which is a forum dedicated to forming community discussions on harm reduction, integration, and safe practices around 5-MeO-DMT.
Download Daniel McQueen of Medicinal Mindfulness joins us to talk about extended-state DMT research, also known as DMTx. Daniel has been presenting this idea at local events in the Colorado area to help raise awareness and money to help bring this research idea to life. To learn more about this project, upcoming events, or to donate to help fund the research check out DMTx.org
Here is a quick message from Daniel:
A few years ago we started a community gathering and speaker series called Psychedelic Shine, and it was through this project that I met Dr. Rick Strassman, Dr. Dennis McKenna, and Dr. Andrew Gallimore, to name a few. The process of creating psychedelic inspired programs, meeting innovative leaders in the field, and also the inner exploration this work requires, were all factors that initiated this journey into exploring Extended-State DMT research. It has been a wild and wonderful ride ever since, and we’re excited to step into the next stage of this work.
It is our intention to create a sustainable, multi-generation DMT research program that is both congruent with scientific inquiry, as well as with the creative and spiritual interests and values of the psychedelic community. We believe Extended-State DMT research is as much an expedition as it is a scientific experiment. We believe it is both deeply inspiring and practically feasible.
Daniel earned a Masters Degree in Transpersonal Counseling Psychology from Naropa and received advanced training in MDMA-assisted psychotherapy through a year internship with the MAPS Boulder MDMA for PTSD Study. It was his experience with MAPS that inspired Daniel to explore alternative visions in psychedelic activism and entrepreneurship.
Daniel bridges transpersonal paradigms with the grounded clinical and organizational skills necessary to begin addressing the significant ecological and mental health crises facing our society today. Although Daniel no longer practices as a clinical psychotherapist, he supports his clients as a teacher, coach, ally and event facilitator, providing individual and group transformational experiences and deeply held intentional conversations. In his practice, Daniel quickly realized that the most important intervention he could provide to his clients, who were isolated and longed for meaningful contact with others, was a sense of community. Medicinal Mindfulness is, in a very real way, a cultural intervention that provides a safe and transformational community container for healing and awakening… a program based on skill development and not dogma. Since 2012, Daniel has been teaching a psychedelic harm prevention and intentional psychedelic use course called Mindful Journeywork. Since the legalization of recreational cannabis in Colorado, he has been facilitating Conscious Cannabis Circles and individual cannabis journeys.
In addition to his work with Medicinal Mindfulness, Daniel has a successful spirituality and life coaching practice with his wife, Alison, through their company, Aspenroots Counseling LLC. Highly skilled in identifying and cultivating giftedness in young people and supporting significant life transitions, Daniel is inspired to support passionate and talented individuals striving to live into their calling. A primary focus of his practice involves assessing and addressing the benefits and difficulties related to psychedelic and cannabis use and misuse.
Daniel co-founded the Naropa Alliance for Psychedelic Studies and helped organize the first annual Psychedelic Symposium at Naropa University in 2012. He is currently working with Grounding Solutions, Inc. to develop a natural rescue medicinal for users of psychedelics and cannabis.
Our online course, ‘Navigating Psychedelics: Lessons on Self-Care & Integration” will keep you and your friends safer. Just say KNOW to drugs.
Kyle and Joe talk with Shane LeMaster about ketamine as a therapeutic tool and also a tool for self-discovery and personal development. Shane shares some amazing stories, and we get to peel off some of the layers around ketamine. There are some amazing uses, and perhaps some therapeutic falling short of the mark in the ketamine world that we discuss. Hope you enjoy!
Shane is a past guest on the show and one of our favorites. You will really like his past episodes where we talked about peyote, treating veterans, Jiujitsu for PTSD and microdosing for athletic performance. (first – second)
Sign up for our course!
Show Topics/Discussion
Chemical effects
Lego world of the Ketamine experience
Hallucinogenic properties of Ketamine for Shane
Astral Projection
Therapeutic method. Music, Temp, Comfort, Safe setting, etc.
Not trauma work – getting to see all of reality as the machine as it is and his role in it.
Shane earned his Bachelor of Arts Degree in Psychology from the University of Colorado in Boulder, CO, completed extensive coursework towards a Master of Arts Degree in Sport & Performance Psychology at the University of Denver, and earned his Master of Arts Degree in Sport & Exercise Psychology from Argosy University.
Shane is nationally certified as a Sport Psychology Consultant and a licensed mental health clinician in the state of Colorado. Having worked in community non-profit mental health since 2008, Shane has gained experience working with the entire spectrum of mental disorders and with all populations and age groups. Shane plans on attending a Ph.D program in Counseling Psychology where his interest in Resiliency, Mental Toughness, and Mindfulness Training Program Development can be explored and further developed.
He is a life-long athlete having competed at various levels in more than a dozen different sports. Because of his passion for warrior cultures of past and present, Shane has been ardently developing his own “Warriorship,” training in various forms of Martial Arts for 25 years. Shane feels that the self-discipline, the philosophy of non-violence, the innumerable mental and physical benefits, and the enjoyment that he gains from the Martial Arts is what helped drive his passion in the field of Psychology.
His personal interest in Eastern Philosophy stems from his adoption of a Buddhist lifestyle and blends well with his training in Western Psychological Science. Clients describe Shane as an out-of-the-box clinician that is easy to get along with, knowledgeable on a variety of topics, credible with lived experience, and as having the ability to make therapy fun and interesting.
Download
What is microdosing? Is this a growing trend in the psychedelic community? What do some people in the psychedelic community think about it? Can it really help boost creativity and productivity? While the idea that microdosing can help with depression, creativity, and productivity, these claims are usually backed by self-reported experiences. There is currently no hard science/research that highlights the risks, safety, or benefits of this concept despite the growing trend and loads of anecdotal evidence. If you want to learn more about this current trend, be sure to get your ticket to the upcoming Psymposia Microdosing event. We are sure all of these questions will be laid out on the table, and it will sure be a great night and discussion!
Brian Normand, Co-Founder of Psymposia, joins us again to talk about the Psymposia Microdosing event/Horizons afterparty. The event will be hosted by the one and only, Duncan Trussell. If you have plans to attend the Horizons: Perspectives on Psychedelics conference in NYC, be sure to check out the afterparty. It is always a great time and also a great place to “find the others.”
Save 5 dollars on your ticket with the coupon code psychedelicstoday
We also cover topics revolving around drug policy and Brian’s experience in the Amazon.
You’re invited to Psymposia’s 4th annual celebration following day 1 of the Horizons Perspectives on Psychedelics forum in New York City that examines the role of psychedelic drugs in science, healing, culture and spirituality.
This year, Comedian Duncan Trussell joins Hamilton Morris (VICELAND’s Hamilton’s Pharmacopeia), Katherine MacLean, Sophia Korb, and Paul Austin to talk about everything you wanted to know about microdosing and more, surrounded by a live audience in Brooklyn.
Co-sponsored by the Multidisciplinary Association for Psychedelic Studies // MAPS
Brian Normand is CoFounder, lead designer, and webmaster of Psymposia. He’s a greenthumb, social entrepreneur & occasional trouble maker, focused on changing minds and creating spaces to teach people about plants and drugs. He graduated from the University of Massachusetts Amherst with a BS in Plant, Soil, Insect Science, & Sustainable Horticulture, Magna Cum Laude.
Download This talk was recorded live in Bolton, Vermont during a MAPS Psychedelic Dinner fundraising event in May 2016.
Lenny Gibson presented a lecture during the event about the brief history of psychedelics in the Western world — surveying the ancient Greek mysteries to the current contemporary psychedelic culture.
“Blessed is he who, having seen these rites,
undertakes the way beneath the Earth.
He knows the end of life,
as well as its divinely granted beginning.” Pindar
Creatures for a day! What is a man?What is he not? A dream of a shadow Is our mortal being. But when there comes to menA gleam of splendour given of heaven,Then rests on them a light of glory And blessed are their days. Pindar
I suddenly became strangely inebriated. The external world became changed as in a dream. Objects appeared to gain in relief; they assumed unusual dimensions; and colours became more glowing. Even self-perception and the sense of time were changed. When the eyes were closed, coloured pictures flashed past in a quickly changing kaleidoscope. After a few hours, the not unpleasant inebriation, which had been experienced whilst I was fully conscious, disappeared. What had caused this condition?
Dr. Albert Hofmann – Laboratory Notes (1943)
To fathom hell or soar angelic, just take a pinch of psychedelic.
Dr Humphry Osmond
Leonard Gibson, Ph.D., graduated from Williams College and earned doctorates from Claremont Graduate School in philosophy and The University of Texas at Austin in psychology. Lenny has 50 years of experience working with non–ordinary states of consciousness. He has taught at The University of Tulsa and Lesley College and served his clinical psychology internship at the Boston, MA V.A. Hospital. He also taught transpersonal psychology for 20 years at Burlington College. Lenny serves on the board of the Community Health Centers of the Rutland Region in Vermont. A survivor of throat cancer, he facilitates the head and neck cancer support group at Dartmouth Hitchcock Medical Center. He is a past president of the Association of Holotropic Breathwork International.
You can find out more about Lenny at these two links.
The summer has been busy for us at Psychedelics Today. We have been working hard on launching our new online course, “Navigating Psychedelics: Lessons on Self-Care & Integration.” Beside lining interviews up for the podcast, we have been recording video interviews/master classes for the course. Since we just launched the course this week, we figured that would check in and just talk about what’s been going on.
This conversation takes off with Joe and Kyle discussing the recent DMTx event that took place last month in Boulder, Colorado. During this talk, we both speculate the risks and concerns of this research as well as the potential benefit. With the conversation revolving around DMT and extended-state DMT research, the discussion heads down the rabbit hole for a bit and we explore the global crisis, climate change, future uses of DMT, alien worlds and alternative dimensions, and more!
We also highlight the recent death of Baylee Ybarra Gatlin, who passed away at the Lightening in a Bottle festival during Memorial Day Weekend. The autopsy report suggests that Gatlin passed due to “Acute LSD Toxicity.” Many condolences to the Ms. Gatlin’s family and friends.
It is very unlikely that Gatlin died from “Acute LSD Toxicity,” but rather most likely from ingesting another substance like 25i-NBOMe. Tragic situations, like these, really stress the importance of substance testing. It seems that with the rise of research chemicals, adulterations in substances, and drugs laced with fentanyl one can never be 100% certain of what they are actually ingesting. If you have the time to ingest, you have the time to test. Get a test kit today.
Leave us a comment and let us know what you think of the show!
This week we talk with Ashley Booth, co-founder of InnerSpace Integration and founder of the Aware Project: Rethinking Psychedelics. Ashley shares with us how she went from being an oceanographer to starting a psychedelic community in the Los Angeles area and also pursuing psychedelic research. We talk about how the formation and history of both the Aware Project and InnerSpace Integration, and the importance of building a psychedelic community.
We also talk about Ashley’s background in somatic practices such as Hakomi and how Hakomi can be used for integration as well as in the psychedelic space. Body psychotherapy seems to be a tool of the future for many psychotherapists who are interested in psychedelics and psychedelic research as normal talk therapy does not always address some of the underlying issues that are stored within the body.
Ashley Booth, M.S. is a scientist, philosopher, and psychedelic ambassador. After years of working in environmental science, she experienced a radical paradigm shift through the use of psychedelics which ignited a passion for the awakening of human consciousness. Ashley uses her scientific background to break through the “war-on-drugs” rhetoric and have an intelligent and scientifically-based conversation about the safety and use of psychedelic substances. Ashley is the founder of the Aware Project: Rethinking Psychedelics (awareproject.org), which hosts educational and community-building events in Los Angeles and San Diego, California. She is also a co-founder of the InnerSpace Integration (innerspaceintegration.com), a psychedelic integration support service and harm reduction organization in Southern California. For a year and a half, she worked as a psycho-spiritual coach at Crossroads Treatment Center, supporting people through ibogaine and 5-MeO-DMT experiences. She is a certified Kundalini yoga teacher and is currently training in a somatic psychotherapy approach known as the Hakomi Method. www.AshleyBooth.net
Download Shane LeMaster joins us again to talk about his work with veterans, enhancing human performance and traditional use of peyote. If you haven’t listened to part one, check that out first here.
Show Topics
Warriorship and Shambhala
Micro-dosing as it would apply to sports performance research
Flow states
Eckhart Tolle
Microdosing at JuJitsu competitions
High or standard dose psychedelic use at NASA
The difference between microdosing and normal dosages
Shane earned his Bachelor of Arts Degree in Psychology from the University of Colorado in Boulder, CO, completed extensive coursework towards a Master of Arts Degree in Sport & Performance Psychology at the University of Denver, and earned his Master of Arts Degree in Sport & Exercise Psychology from Argosy University.
Shane is nationally certified as a Sport Psychology Consultant and a licensed mental health clinician in the state of Colorado. Having worked in community non-profit mental health since 2008, Shane has gained experience working with the entire spectrum of mental disorders and with all populations and age groups. Shane plans on attending a Ph.D program in Counseling Psychology where his interest in Resiliency, Mental Toughness, and Mindfulness Training Program Development can be explored and further developed.
He is a life-long athlete having competed at various levels in more than a dozen different sports. Because of his passion for warrior cultures of past and present, Shane has been ardently developing his own “Warriorship,” training in various forms of Martial Arts for 25 years. Shane feels that the self-discipline, the philosophy of non-violence, the innumerable mental and physical benefits, and the enjoyment that he gains from the Martial Arts is what helped drive his passion in the field of Psychology.
His personal interest in Eastern Philosophy stems from his adoption of a Buddhist lifestyle and blends well with his training in Western Psychological Science. Clients describe Shane as an out-of-the-box clinician that is easy to get along with, knowledgeable on a variety of topics, credible with lived experience, and as having the ability to make therapy fun and interesting.
Interested in learning more about psychedelic self-care and integration? Check out and sign up for our new online course!
Doing work with veterans and gaining their trust for therapeutic relationships.
Traditional approaches to ayahuasca.
First hand accounts of what the Peyote world is like.
Shifting away from the predominant Newtonian Cartesian paradigm after psychedelic use and understanding that we know very little about what is really happening here in the world.
Shane earned his Bachelor of Arts Degree in Psychology from the University of Colorado in Boulder, CO, completed extensive coursework towards a Master of Arts Degree in Sport & Performance Psychology at the University of Denver, and earned his Master of Arts Degree in Sport & Exercise Psychology from Argosy University.
Shane is nationally certified as a Sport Psychology Consultant and a licensed mental health clinician in the state of Colorado. Having worked in community non-profit mental health since 2008, Shane has gained experience working with the entire spectrum of mental disorders and with all populations and age groups. Shane plans on attending a Ph.D program in Counseling Psychology where his interest in Resiliency, Mental Toughness, and Mindfulness Training Program Development can be explored and further developed.
He is a life-long athlete having competed at various levels in more than a dozen different sports. Because of his passion for warrior cultures of past and present, Shane has been ardently developing his own “Warriorship,” training in various forms of Martial Arts for 25 years. Shane feels that the self-discipline, the philosophy of non-violence, the innumerable mental and physical benefits, and the enjoyment that he gains from the Martial Arts is what helped drive his passion in the field of Psychology.
His personal interest in Eastern Philosophy stems from his adoption of a Buddhist lifestyle and blends well with his training in Western Psychological Science. Clients describe Shane as an out-of-the-box clinician that is easy to get along with, knowledgeable on a variety of topics, credible with lived experience, and as having the ability to make therapy fun and interesting.
Interested in learning more about psychedelic self-care and integration? Check out and sign up for our new online course!
David Stetson – Oka Center Ibogaine – Ibogaine Therapy
IBOGAINE and AYAHUASCA in the MAYAN YUCATÁN
Kyle and Joe discuss iboga and ibogaine with David Stetson who runs Oka Ibogaine Center in the Yucatan Peninsula of Mexico. David was a wonderful guest on the show and we had a lovely talk that was very broad. We discussed the ecological issues surrounding iboga and ibogaine therapy, as well as the differences between the more traditional model and the clinical model of administering these medicines. Oka has recently started offering ayahuasca retreats as well.
We also get to talk about the idea of psychedelic aftercare facilities and they are substantial importance for people requiring serious psychedelic work to heal. When healing, going back to your old life is often not the best decision. The inpatient rehab model is something that we should really look at. The Holistic House in the Las Vegas area is one successful model and we are very excited about it.
We hope you enjoy the episode and reach out if you have any questions or comments.
Our place is a marriage of two different worlds: While we respect and utilize western clinical protocols for safety and detox success, we love and live by our numerous and ongoing experiences with the traditional use of these master plants in Africa and Peru.
David’s passion has been Bwiti since his Iboga initiation in 2007. It’s his privilege to be sharing this medicine with people in need.
David is extensively well-traveled in Gabon, Africa where he is known as Okukwe. During his time in Gabon he learned Bwiti traditions, music, and ceremonial practices and is proficient on both the moungongo (musical bow) and ngombi (harp) instruments.
David views Bwiti and Ibogaine as a lifeway that champions communion with others while also empowering the individual. His approach to working and healing with others starts with the awareness of alienation and isolation as common and appropriate responses to our western culture, and is based in nonjudgement.
We discuss our recent trip to MAPS‘s Psychedelic Science 2017. It was incredibly fun and we loved being able to connect with so many with this shared interest. Many attendees are actively working to progress the case of psychedelic substances.
This was the largest psychedelic conference ever in recorded history attended by over 3000 people from 42 countries. There were discussions around ayahuasca, peyote, DMT, salvia, MDMA and many other substances. Some of the most interesting discussions were around ibogaine treating people with addiction. Turns out there are far more things that can be treated with ibogaine than simply opiate addiction.
I was very excited to discuss drug testing and harm reduction with the people from DanceSafe. We were also able to check out some really interesting technology – lights and music – that triggered some of the most intense visuals of my life. Illuminated SF put that demonstration together. It is highly recommend.
The experience of Psychedelic Science 17 was so incredible and encouraging that I cannot wait to go to the next one. Being around the movement was truly humbling and gratifying. Connecting with people from as far as Brussels, Poland and Hong Kong gave extra context to how far and wide this movement is spreading and that there is real depth in the movement.
We hope you enjoy the episode. If you want to connect with us please feel free to reach out using the contact page. If you want to stay in touch with us please join our mailing list and we will send some interesting links to you on a semi regular basis.
Links
https://www.solarwolfenergy.com/
https://maps.org
MAPS made available a tremendous amount of the talks for free on youtube. You should spend some time digging through the talks for things you may find very interesting.
Kyle and Joe recently chatted with a second therapist who works underground. Trained as a traditional therapist, this therapist integrates MDMA work into her practice with selective clients. She has been mentored by a teacher who has done this work for a very long period of time. She has a community of therapists around her providing support.
MDMA is not a typical psychedelic drug but it is the focus of most of MAPS’s efforts in the Psychedelic Psychotherapy world. Psychedelic therapy is THE frontier of psychology. Therapists like Selina are on the vanguard of these therapies. By working underground they have great risks (legal) and advantages (huge amounts of healing for their patients).
Why are we waiting? We are in a mental health crisis, far too many people are suffering and committing suicide. If one compares this to any recent “outbreak” the numbers certainly make sense to fast track MDMA as a viable therapy for PTSD and other disorders.
We want to keep interviewing people doing underground work, so please send them our way for interviews. We are going to be able to provide anonymity for those that want it, so feel free to ask about this if you want it.
Enjoy!!
MDMA Therapist – Show Notes
Dosage for sessions
135-140 mg starting dose
80 mg booster (optional)
Psilocybin dosing – Depends on what type of experience a person is looking for
We will not provide any information about this therapist. Please do not email/contact us about therapy sessions or gaining information about the therapist. These interviews are anonymous and private. We can provide general advice. We will not provide any information about this or other anonymous guests of the show. Thanks for understanding!
“Can I use my mind as a tool to help me open a closed heart?”
We talked to a 79-year-old underground MDMA psychotherapist. Remaining anonymous, due to the illegality of this work, he shares some of his greatest insights from his many years of experience helping people with psychedelic therapy. Succeeding a twenty-year hiatus from MDMA therapy, he continues to provide this healing psychedelic work to individuals today.
The following is an excerpt from our interview. Check out the full audio interview here.
Edited by: Alyssa Gursky
MDMA – Confessions of an Underground Therapist
Psychedelics Today: How did you get exposed to the literature and science around psychedelics in those early days?
Anonymous: It wasn’t the literature. In 1958, when I was 20 years old, someone got a hold of some acid. I was living in Boston and a friend of mine said,
“Would you like to try this new drug?”
I was naïve and I didn’t know. The only drug I’d ever consumed was alcohol. I said, “It is habit-forming?” They said, “No.” I said, “Alright. I’ll try it.”
I told my friend I was going to try it that day. The next day, when I met him on the street, he asks, “How was it?” I said, “Considerably more interesting than the sum total of my life up until this point.”
Psychedelics Today: What has surprised you the most about working with people at MDMA? Do you see rapid transformations? Is it kind of a catalyst for a longer set of transformations or transformational process? How do you think about it?
Anonymous: In order to answer that, I have to emphasize that people are in different stages of understanding and growth in their own level of self-knowledge. Also, people have set a lot of defenses against change in the conscious and unconscious mind.
I especially like looking at relationships; relationship to one’s self, relationship to nature and something beyond one’s self and relationship to one’s friends, to one’s lover, or one’s past lovers, and to the people that push your buttons. Looking at the difference between the way that the relationship feels normally and the way you feel towards the person when your heart is more open because of the medicine is the greatest benefit, in my eyes. Looking at those relationships, people sometimes get glimpses of what it could feel like if their hearts were open instead of closed. Sometimes, they even realize that they do not have any good reason to keep it closed.
Psychedelics Today: It’s like one of its better effects is just kind of a reorientation towards daily life. No need to be closed off, no need to be fearful.
Anonymous: Of course. That doesn’t mean they don’t go back to being have been closed off and fearful, but when you go back to the old place because you’ve tasted the new place, the old place is never quite the same.
Psychedelics Today: I am am curious if you could share any stories of people’s healing, anonymized, of course.
Anonymous: One comes to mind, a man who was brought up in a minority community out West and was molested by a man who was not part of the community. The man told him at the end, “You better not tell anyone about this or else … ” and he threatened him with something pretty terrible. This young boy did tell. He told his people in his community. They found the man and beat him until he was at the ends of his life. My client told me that he felt really guilty for what had happened, even though it’s not rational to feel guilty. He felt really guilty and the guilt spilled over until many areas of his life and was the sort of central pillar of his psychology, this feeling of being bad, unworthy of love as a result of that.
When he took the medicine, he told me about his situation. I just asked him, “Pretend that it is your son who gets molested and is told that he mustn’t tell and then, he told anyway; how would you feel towards him?” He had a moment’s pause and said, “I will just love him.” Then, he made the connection himself and there was a visible, immediate change that came over his facial expression and looked like a different person. He dropped the majority of his guilt. It stayed with him because I saw him the next day and he still looked much more relaxed, whole, and happy. He said that there was a fundamental shift in him as a result that couldn’t just end when the effects of the medicine wore off.
Relating to my own growth, I found that emotional maturity and self exploration are key portions of my journey. I found that every single relational difficulty that I found in myself, if I looked at it it deep enough, brought me to the same lesson- that I wasn’t being kind to myself. When I’m feeling good about myself, I just don’t have relational difficulties. Of course, most of us have a ways to go before we can feel good about ourselves. Another thing, I realized, is the hurt doesn’t come from rejection, it comes from my taking offense at rejection. If I learn not to take offense, I’ll get hurt a lot less. That would just be an example of a much bigger principle.
Psychedelics Today: I really appreciate your focus on the relationship aspect of healing work. My teacher and I were discussing psychedelic use in traditional cultures. To the Native Americans, Peyote usage is all about relationship; a relationship to the medicine, a relationship to the universe. It doesn’t seem like that’s always the case.
When we were asking another teacher about like, “How would you pitch breathwork to somebody that’s interested?” His first response was, “Are you curious? Are you curious about your relationship to the world?” I think that’s kind of like the cornerstone of self-discovery. It’s about learning about your relationship to yourself, learning about your relationship to others, learning about your relationship to the universe and how you interact with it.
Anonymous: One more side on the matter is that I look at the spiritual literature of the world. I noticed that there’s very little believable and useful literature about intimate partnerships between two equal people in the spiritual literature. Most spiritual literature just says, “Be loving. Be kind. Be forgiving.” That’s very nice, but they don’t talk about how do you do that when your heart is closed?
I think the deepest question when one is in relationship is, am I safe? Is it safe for me to love? Do I need to close my heart in order to stay safe? I believe the answer to that question is always no, but we often think it’s yes.
The MDMA affected my work by the nature of the changes it brought about in me. We saw things about opening… I really saw that the central issue for most people is very simply put, the need to open the closed heart. I look at everything in the world that I found distasteful; war and violence, starvation and hunger, economic inequality, environmental disaster, the stuff that goes on in the homes, and every single thing seemed like it wouldn’t take place if they were loved.
It seemed like the same factor that caused disharmony in the home is what caused war among nations, you know, like “as above, so below.” It felt like there’s this one change needed in the human consciousness which could be summarized by the opening of the closed heart, and that became my biggest interest. Can I use my mind as a tool to help me open the closed heart?
Psychedelics Today: Looking back at all these years of doing your own self-exploration and providing a space for people to do their own exploration and healing, is there a piece of advice that you have gathered and would like to pass on? You must have seen a lot and been through a lot. To us, you are this elder passing some serious wisdom on. I’m curious if you have any deep insights.
Anonymous: Boy! From what I’ve experienced, I can say that most of the time, people start from an assumption that the world is unsafe. In order to make it safe, they attempt to control people, events, and circumstances. If you start with “I’m not safe,” then the only thing I’ll ever arrive at is, “I’m still not safe.” We’re all looking for a feeling of deep, deep safety. I think safety is like love. The only safety worth anything is unconditional safety. A safety that doesn’t depend on circumstances is the most valuable because circumstances are out of our control. I think that the piece of advice would be — consider the possibility that the world is safe. Start with that and see where that takes you.
Psychedelics Today: Thank you for that. That’s a really, really great piece of insight.
MDMA is hugely beneficial for some (most?) people, and it makes sense to optimize for the best outcome. People can now try this on their own. It is easier and safer than ever. With all of the new research being published, this is happening with increasing frequency. Interested in learning about integration and self-care? Be sure to check out our “Psychedelic Integration & Self-Care” course! Free course preview in the sign up link below. Learn about MDMA and many other drugs in the course we created for you and your friends.
Download Kevin is a science writer, graduate student researcher and aspiring clinician, harm reduction educator and substance use recovery advocate. Kyle and Joe talk to him about loads of topics including early Iboga therapies, an early Boston Ibogaine Conference, his approach to journalism and his future aspirations to do future clinical work and research.
Kevin graduated from Northeastern University in 2013 with a degree in neuroscience. As an undergraduate he completed an internship as a research assistant at Harvard Medical School working on the Phase 2 dose-response study investigating the therapeutic potential of MDMA-assisted psychotherapy for treatment of cancer related anxiety. Kevin was also one of the founders of the Northeastern chapter of Students for Sensible Drug Policy, and in 2009 the group hosted and co-sponsored the Boston Ibogaine Forum. He now lives in New York City where he is enrolled in a clinical psychology graduate program at The New School for Social Research and is pursuing a doctoral degree. Kevin has worked part-time for the Drug Policy Alliance, and also works as a writer covering topics related to psychedelic therapy, addiction, and mental health advocacy. His recent contributions include: New Scientist, Reason.com, Reset.me, Reality Sandwich, and VICE.com.
Download
Psymposia’s MC and Host, Lex Pelger, joins us again on Psychedelics Today to talk about Psymposia’s upcoming Blue Dot Tour. Lex also talks about his graphic novel about cannabis, the endocannabinoid system, and the War on Weed.
Our goal is to hit blue cities in red states that serve as such pressure cookers of activism, education, and art. But also blue cities in blue states, red towns in red states, purple villages in green states, and anywhere we can find a host from Mexico to Canada.
Lex is Host of Psymposia. He’s also a drug writer and scientist based in Brooklyn.
His current project, Anandamide or: the Cannabinoid a graphic novel about cannabis (based on Moby Dick), illustrates the beauties of the endocannabinoid system (the Whale), the brutalities of the racist War on Weed (Ahab), and the staggering benefits of medical marijuana to ease the aging of our grandparents
He graduated from Boston University with a BS in Biochemistry and Molecular Biology
Kyle and Joe speak with, Paul Austin, psychedelic educator, founder of The Third Wave and Psychedelia. Paul is a super fun guy to talk to. He tours both in the US and internationally to speak about microdosing. Microdosing is becoming incredibly popular and seems to be making psychedelics more popular in the mainstream. Microdosing can help with creativity, therapy and many other things without any of the burden of a “full” dose.
What is the psychedelic Third Wave? Paul describes it as:
A new era of psychedelic use. It is an era of psychedelic use defined by practical, measured use for specific purposes. It is an era, not for ‘dropping-out’ of society, but for integrating psychedelics into the mainstream. It is an era, not to fear psychedelics for their possible negative repercussions, but to embrace psychedelics for their tremendous upside.
Some insight from DR. JAMES FADIMAN
“For some people, it is helpful to identify your goals. Your goals may be spiritual: to have direct experience with aspects of your tradition or another tradition, to transcend prior beliefs, even to transcend belief itself. You may hope to have what is called a “unity experience,” in which there is no separation between your identity and all else. Your goals may be social: to improve relationships with your spouse, children, siblings, parents, colleagues, friends, and spiritual and secular institutions. Your goals may be psychological: to find insight into neurotic patterns, phobias, or unresolved anger or grief.”
We get into some great psychedelic topics such as:
As an entrepreneur and avid psychedelic explorer, Paul believes in the power of rational dialogue and community engagement in stripping away the stigma around psychedelic use.
He understands the power of responsible psychedelic use in aiding psycho-spiritual development, and believes in sharing this message with others.
When not ruminating on his next psychedelic project, Paul enjoys traveling, reading, and spending time outside.
Kyle and Joe talk to an anonymous MDMA therapist and relationship coach. He has been working with people while they use MDMA beginning in the early days while it was still legal and continues to facilitate work with people while it is prohibited.
For his safety, his identity is kept anonymous. The insights here are wonderful and worth learning. Hopefully you will learn something here and it can be applied to future therapies once we hit the 2021 MAPS target date.
Some interesting thoughts from the interview:
Transcending the parent-child relationship.
We are human beings that can be in good relationship with one another.
Do I feel safe? What does it mean to feel safe?
Appropriate dosages.
Intuitive approaches for engaging with the client patient.
Download Joe and Kyle talk to Shannon Clare Petitt about the current state of MDMA research and what MAPS needs to do in the next number of months with the FDA as the phase three trials become approved. A few days after the interview the New York Times reported that the phase three research was approved. Shannon’s story is great and optimistic. If you are interested in how to get a job in the psychedelic field, this is certainly an episode you’ll want to listen to. We also discuss some possible tweaks to the studies that could be done that may yield interesting results, and also why MAPS is taking the approach that they are (its the most straightforward way to push the research through the FDA). Continue reading “Shannon Clare Petitt – MAPS, Zendo and an update on MDMA’s status”
Faan was a great guest. He is currently working on a cannabis startup in Montréal, Québec, Canada named Indeeva Biomedical. Joe previously interviewed Faan for his permaulture podcast Permaculture Salad to talk about how shamanism, ayahuasca and permaculture go together in a complementary way (link). At the time of that interview Faan was living on a permaculture/ayahuasca retreat center in Peru named the Paititi Institute.Continue reading “Faan Rossouw – Indeeva Biomedical”
Download Kyle recently had the great opportunity to attend one module of the MAPS MDMA Therapy sessions. In this episode we talk about the experience at the workshop and about some other valuable topics as well. Let us know what you think, and please leave a review on iTunes! Continue reading “Kyle and Joe – MAPS MDMA training in New York”
Tom Shroder Joe and Kyle talk about Tom’s great book titled “Acid Test: LSD, Ecstasy, and the Power to Heal”. Tom is an editor, and author of a number of books as well as the former editor of the Washington Post.
Interviewing Tom was real fun and we appreciate him joining us for the show.
We get into some great topics including
Tom’s interesting connection to Rick Doblin
The history of Rick’s rise to influence
The story of the Mithoefers transitioning from emergency medicine and sailing to Holotropic Breathwork and MDMA research
The book and this interview also follow the story of a US Marine who came home with treatment resistant PTSD and was then treated by the Mithoefers with MDMA as part of their research.
The book is amazing and well worth your time if you want to get familiarized with the hopes and history of psychedelic research.
Ingmar Gorman, M.A. is a currently unlicensed doctoral student in Clinical Psychology at the New School for Social Research. His clinical work is supervised by licensed clinical psychologists at his training sites. After receiving his B.A. in Psychology from the New College of Florida. Ingmar completed a pre-doctoral externship at Bellevue’s Chemical Dependency Outpatient Program and Dual Diagnosis Inpatient Unit, where he obtained specialized training in treating people living with substance use disorders. He has also gained extensive experience treating severe mental illness at South Beach Psychiatric Hospital’s Heights Hill Outpatient Clinic. Ingmar has trained in individual and group psychotherapy at Beth Israel Medical Center’s Psychiatric Inpatient Services, as well as the Brief Psychotherapy Research Program. Ingmar uses an integrative approach to treatment utilizing Cognitive Behavioral Therapy (CBT) and Psychodynamic principles. When treating substance misuse, Ingmar draws on his extensive training with Dr. Andrew Tatarsky and Dr. Jen Talley, in Harm Reduction Psychotherapy and Mindfulness based approaches.
Kyle and Joe speak with Djinn Thompson about their podcast Psychedelic Parenting and the future of the Psychedelic Parenting organization. Other topics that were covered include:
Talking about psychedelics and substances with teenagers and children
The Aftercare Project and psychedelic integration, and holding space.
How to pass on the values of the psychedelic experience through spirituality, conscious living, social justice, free expression, and radical honesty.
Djinn has over 20 years’ experience with psychedelic plants and has been trip sitting in a professional capacity for over a decade, having served as a facilitator for legal psilocybin retreats in Jamaica and other venues. Djinn specializes in working with victims of childhood trauma, those with treatment-resistant depression, and issues related to LGBTQ identities. Djinn came out as a nonbinary trans person in 2017. They are currently pursuing a Masters Degree in Social Work. Djinn was previously the host of the Psychedelic Parenting Podcast under their birth name, and has been a speaker on psychedelics and family life at multiple conferences, both in the USA and abroad.
Hope everyone enjoys this episode. We really enjoyed talking to Djinn and feel blessed by their wealth of knowledge and wisdom. Let us know what you think!
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Lex, Kyle and Joe discuss MAPS, Psymposia, Ibogaine, Mushrooms, Ketamine, LSD, Cannabis, and loads more. Lex is working on a book related to the supremely complex neurochemistry of cannabis.