Substances

Chad Charles – Integrating 5-MeO-DMT: Therapy, Harm Reduction, and Best Practices

July 29, 2025
Featuring: Chad Charles

In this episode of Psychedelics Today, Joe Moore sits down with Chad Charles — educator, mentor, and practitioner specializing in 5-MeO-DMT therapy.

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In this episode of Psychedelics Today, Joe Moore sits down with Chad Charles — educator, mentor, and practitioner specializing in 5-MeO-DMT therapy.

Chad shares his decade-long journey working with 5-MeO-DMT, emphasizing the importance of:

  • Practitioner training and mentorship
  • Personalized, therapeutic alliances
  • The nuanced understanding of dissociative states
  • Ethics in standardized clinical dosing
  • A trauma-informed approach to psychedelic care

He also introduces his upcoming research project, analyzing 500+ one-on-one sessions to illuminate best practices and ethical frameworks in the 5-MeO-DMT space. This is a must-listen for anyone passionate about harm reduction, responsible facilitation, and the future of psychedelic therapy.


🕒 Episode Breakdown

  • 00:00 – Introduction and Guest Welcome
  • 00:41 – Chad Charles’ Background and Work
  • 02:18 – Defining 5-MeO-DMT
  • 05:28 – Breathwork and Therapy
  • 09:22 – First Experiences with 5-MeO-DMT
  • 18:00 – Training and Ethical Considerations
  • 30:41 – Conscious Surrender vs. Submission Experience
  • 31:18 – Ethical Considerations in Psychedelic Research
  • 32:02 – Understanding Dissociative Doses
  • 33:26 – Empowering Individuals Through Therapeutic Alliance
  • 34:26 – Challenges in Contemporary Science
  • 38:02 – Good Practice vs. Malpractice in Psychedelic Therapy
  • 41:51 – Personal Experience and Practitioner Responsibility
  • 46:52 – Addressing Malpractice and Corrective Experiences
  • 01:00:11 – Physical Health Considerations in Psychedelic Therapy
  • 01:02:21 – Future Directions and Research in Psychedelic Therapy
  • 01:05:43 – Conclusion and Contact Information