Research

Rumination, the Default Mode Network, and How Neuroplasticity Changes Over Time

August 13, 2024
Featuring: Dr. Jerry Rosenbaum & Sharmin Ghaznavi, MD, Ph.D.

Rumination, or repetitive self-focused thought that’s typically critical and/or negative, is at the heart of many psychiatric disorders. Could psychedelics and psychedelic-assisted therapy help?

Subscribe Share

Rumination, or repetitive self-focused thought that’s typically critical and/or negative, is at the heart of many psychiatric disorders. Could psychedelics and psychedelic-assisted therapy help?

In this episode, Chris Koddermann interviews two members of the Center for the Neuroscience of Psychedelics at Mass General Hospital: founding director, author, and co-founder of three drug development companies, Dr. Jerry Rosenbaum; and psychiatrist and associate director and director of cognitive neuroscience, Sharmin Ghaznavi, MD, Ph.D.

Rosenbaum and Ghaznavi bonded over an interest in rumination, and wondered: How could the plasticity-inducing effects of psychedelics change these negative loops people find themselves in? How important is the ability to break out of those loops – and learn new patterns – when our concept of self is so central to who we are? Ghaznavi is studying the effects of psilocybin on rumination and scanning patients at multiple times throughout the process to track data we still don’t really have: how psychedelic-induced neuroplasticity changes over time, and why.

They discuss:

  • How much of a role the default mode network takes in the therapeutic benefits of psychedelics: Is it overblown?
  • Hyperscanning, which involves scanning two individuals at the same time, looking for potential concordance in signal and/or an increased alliance between the therapist and patient
  • The Schultes Legacy Project and the work of Stephen Haggarty to explore the potential of largely unstudied psychoactive plants
  • Critiques of the recent ruling on Lykos and MDMA-assisted therapy and the clash between the FDA and the advisory committee: Were they really on the same page?
  • The false dichotomy of neuroscience vs. patient experience: Does the subjective experience actually increase plasticity and other measurable benefits?

and more!

Links

The Center for the Neuroscience of Psychedelics

Sheppardpratt.org: First-Ever Psilocybin Clinical Trial for Treatment of Bipolar II Depression Conducted at Sheppard Pratt Reveals Promising Results

Psypost.org: Therapeutic alliance plays a key role in MDMA-assisted psychotherapy for PTSD

Mghcme.org: Psychedelics and Pain: Understanding the Roles of Psychedelics and Clinicians in Facilitating Brain Change

Haggartylab.org

Plants of the Gods: Their Sacred, Healing, and Hallucinogenic Powers, by Richard Evans Schultes, Albert Hofmann, Christian Rätsch

Psythx.com

Sensorium.bio

Entheoslabs.com

*Amazon links are affiliate links, meaning that Psychedelics Today will receive a percentage of the sale

Dr. Jerry Rosenbaum

In this Episode

Dr. Jerry Rosenbaum

Until 2019 and for 20 years, Dr. Rosenbaum, Stanley Cobb Professor of Psychiatry at Harvard Medical School, chaired a department of 600 clinicians and researchers, and 150 trainees, ranked by U.S. News and World Report as #1 in the United States in 2019, and for 20 of the prior 24 years, with 60 specialty clinical and research programs and over 70 million dollars of annual research spending. At MGH, the nation’s largest hospital based research institution, with over 1 billion dollars of annual research, he served as Chair of the Executive Committee on Research. The 2007 recipient of the C. Charles Burlingame Award for lifetime achievement in psychiatric research and education, he was the 2016 recipient of the Joseph B. Martin Dean’s Leadership Award for the Advancement of Women Faculty for Harvard Medical School. Emeritus Fellow of the ACNP, he is a 2018 Ellis Island Medal of Honor awardee. Past President/Board Chair of the Anxiety and Depression Association of America (ADAA), he served as Chair of the Scientific Council, President and Board member of the American Foundation for Suicide Prevention. He served a six year term as Trustee of the Massachusetts General Hospital, three years as Trustee of the Partners Healthcare System, and now co-Chair of Development at MGH. He is the co-author of more than 400 original articles and reviews, and editor of 20 books. He led longitudinal studies of children at risk for anxiety disorders and depression, examining behavioral differences, risk factors, longitudinal outcomes, treatment, genetics, and brain structure and function of children of parents with mood and anxiety disorders.

He currently is directing the MGH Center for Neuroscience of Psychedelics (CNP), to understand how psychedelics change the brain and to explore novel mechanisms for treatment of psychiatric disorders. He co-founded Psy Therapeutics to advance the discovery of novel drugs for psychiatric and neurologic disorders, co-founded Sensorium Therapeutics to explore plant derived molecules as leads for novel psychiatric therapeutics, and co-founded Entheos Labs, Inc. to bioengineer novel psychedelic botanicals to deliver a new generation of psychedelic-derived therapeutic molecules. He graduated in 1969 from Yale College and 1973 from Yale Medical School and trained in Psychiatry at Massachusetts General Hospital, Harvard Medical School.

Socials: Linkedin

Sharmin Ghaznavi_ MD_ Ph.D.

Sharmin Ghaznavi, MD, Ph.D.

Sharmin Ghaznavi, MD, Ph.D., is the Associate Director and the Scientific Director of Cognitive Neuroscience at the Center for the Neuroscience of Psychedelics (CNP) at Massachusetts General Hospital. She is leading the Center’s first studies on the effects of psilocybin on rumination and other cognitive processes in major depression. Dr. Ghaznavi received her undergraduate degrees in biology, brain and cognitive sciences, and philosophy from the Massachusetts Institute of Technology. She obtained her medical degree, masters degree in philosophy, and Ph.D. in neuroscience from Yale University and completed a residency in adult psychiatry at the Mass General/McLean Psychiatry Residency Program. Dr. Ghaznavi’s research interests are the neural correlates of cognitive, affective and social processing in psychiatric illness. Dr. Ghaznavi has been the recipient of the Dupont-Warren and Livingston psychiatric research fellowships from Harvard Medical School and a 2012 NARSAD Young Investigator Award from the Brain and Behavior Research Foundation.