Research

PT431 – The Concept of Integration and the Need for Evolving Protocols of Psychedelic Therapy

August 11, 2023
Featuring: Matthew W. Johnson, Ph.D.

In this episode, Kyle interviews The Susan Hill Ward Endowed Professor of Psychedelics and Consciousness Research at Johns Hopkins, and renowned researcher of nearly 20 years: Matthew W. Johnson, Ph.D.

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In this episode, Kyle interviews The Susan Hill Ward Endowed Professor of Psychedelics and Consciousness Research at Johns Hopkins, and renowned researcher of nearly 20 years: Matthew W. Johnson, Ph.D.

Recorded in-person at MAPS’ Psychedelic Science after running an 8-hour workshop on psychedelic therapy for addiction treatment, Johnson was still happy to sit down with PT to explore a wide range of topics: the under-researched concept of integration; how to best take advantage of optimal neuroplastic windows; why psycholytic therapy used to be more common; how our current protocols and research models are largely arbitrary; and his hopes for new, experimental, and flexible models of psychedelic therapy.

He also discusses his ongoing smoking cessation studies; the Oregon model (are we doing therapy or not?); misrepresentation in psychedelic therapy and knowing your lane; and the role of music in psychedelics: why shouldn’t people pick the music they know will give them goosebumps?

Notable Quotes

“How in the world could there be these beneficial effects that we can see in someone’s behavior (their substance use, their depression) 6 months, a year later from one, two, or three medication experiences that were time-limited? …People are changing the way they’re operating. And the more you start to do that, and that starts to become the new normal, so it’s not just ending at the psychedelic session or even in the explicit integration sessions where you talk about your psychedelic therapy or your psychedelic session; but then, if you put into practice – like actually changing the way you’re operating in the world and that becomes the new normal – I think that’s what’s happening to explain why we’re seeing these beneficial effects six months, a year later. It’s just kind of the causal nature of the therapeutic mechanisms unfolding over time in a kind of a living, organic way, because people are interfacing with reality in a different way, that can, if they’re doing it right, it can have a feed-forward effect, like, ‘Oh, this actually works. I feel better. I’m doing better in life when I do things more this way than the way I used to do them.’”

“The nice thing that’s probably going to happen once we get out of this phase, at least with, like, psilocybin and MDMA where it’s only in clinical approved research now, if they’re approved by the FDA for straight up treatment, FDA is not going to control what music you use or how you integrate and all these other things. And so there’s going to be this wave of naturalistic experimentation which is going to be really cool. And then hopefully people are safe, but hopefully there’s an integration of the communication of the art of the practice of medicine and psychology. It’s like just through that communication – like what tends to work, what tends not to work, people sharing ideas – I’m looking forward to that.”

Links

Hopkinsmedicine.org: Matthew W. Johnson, Ph.D.

Psychedelics Today: PT229 – Dr. Matthew Johnson – What is Consciousness?

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Matthew W. Johnson, Ph.D. 2

In this Episode

Matthew W. Johnson, Ph.D.

Matthew W. Johnson, Ph.D., is The Susan Hill Ward Endowed Professor of Psychedelics and Consciousness Research at Johns Hopkins. Working with psychedelics since 2004, he has played a role in the modern-day revival of psychedelic research. He has published research on psychedelics and mystical experience, personality change, tobacco smoking cessation, cancer distress treatment, and depression treatment. In 2021 he received as principal investigator the first grant in about 50 years from the US government to administer a classic psychedelic as a treatment, specifically psilocybin for tobacco addiction. He is also known for his expertise in behavioral economics, addiction, sexual risk behavior, and research with a wide variety of drug classes. He has been Interviewed by Anderson Cooper on 60 Minutes, the New York Times, the Washington Post, the Wall Street Journal, CNN, NPR, Fox News, BBC, the Lex Fridman Podcast, and in Michael Pollan’s book, How to Change Your Mind.

Socials: Twitter