David Krantz – Epigenetic Interactions on Substance Effects


In this episode, Kyle interviews David Krantz, Certified Epigenetic Coach, and an expert in nutritional genomics. In the show, they talk about the effects of substances via the implications on an individual’s genetics.

3 Key Points:

  1. Epigenetic testing is a bio-hack for boosting cognitive function and harnessing our creativity and ultimate human potential.
  2. There has been a lot of research done on genetics and the effects of THC. The body produces cannabinoids that activate the THC receptors internally, which varies from person to person.
  3. Each person should be seen on an individual level, and the more we know about our unique genetics, the more we can understand about our interactions with different substances.

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Show Notes

About David

  • David works with clients on creating optimal epigenetic expression
  • He uses people’s genetics as a guide to look at recommendations for diet, herbs, supplements, etc.
  • He began looking at cannabis for recommendations and found curiosity in psychedelics too
  • Epigenetics studies the effects of the modification of genetics
    • It looks at chemical groups attached to the DNA itself and what happens to them over time

Cannabis and Genetics

  • The most robust area of research on genetics is THC
  • David said he has seen some research on Psilocybin and just very recently that liver enzymes are responsible for LSD interactions
  • It looks at the way people are metabolizing these substances
  • When you ingest something or smoke it, it has a higher impact on the body, edibles are a great example
    • Kyle brings up the curiosity of edibles impact being either physiological or biological
  • Genetics show the body’s cannabinoid levels
    • The body produces cannabinoids that activate the THC receptors internally
    • There are two enzymes that break down cannabinoids in the body, Anandamide and 2AG
  • There is a higher likelihood to use cannabis in a person with lower levels of endocannabinoids
    • This makes some people high-functioning stoners, and others non-functioning stoners
    • The substance is neutral, it’s all about the body and how it reacts to it
  • When the liver breaks down an edible, it makes THC more potent
  • There is speculation that the slow metabolizers have a better chance of passing a drug test because they don’t have a chance to convert 110HTHC to the COOHTHC

Food and Substance Effects

  • Kyle mentions someone who was drinking grapefruit juice everyday for 3 weeks, and it potentiated the effects of Ketamine
  • In order to psilocybin to be converted to psilocin, you need a chemical in your body called alkaline phosphatase
    • Vitamin C deficiency and Vitamin B-6 deficiency all both correlated with alkaline phosphatase deficiency
  • David brings up his experience going keto, it worked really great for him, his energy levels increased, he lost weight, but his wife had a horrible time with keto
    • Then he looked to genetics and it made perfect sense to him as to why it worked for him and why it failed for her
  • Metabolism, biochemistry, genetics, and so many other factors impact a person’s reaction to substances

Gene Type Testing

  • Apeiron
    • David also mentions that with companies like 23 and me, they get their money from selling people’s genetic information
    • He says Apeiron is focused on what you can actually do with the information, not just simply providing the results
  • David says its super valuable for people to know these things about themselves, how to mitigate stress, how the metabolism works, knowing what to eat, knowing vitamin deficiencies, etc.

Psychedelics in the Future of Epigenetics

  • David thinks were going to see that the epigenetics of psychedelics are going to show the ability to overcome trauma
  • When we look at people at an individual level, we all have our own idiosyncrasies and variations
  • “Because there is no such thing as an average human, let’s stop treating people like average humans and start treating them like they are individual people. Let’s stop leaving out the outliers.” – David
  • Taking an individualized approach to the psychedelic space is highly beneficial




About David

David Krantz is a certified Epigenetic Coach who specializes in boosting cognitive function and helping clients harness their creative and personal power. As a lifelong musician, David sees the various systems of the body as parts of a complex symphony. And, as a coach, he excels at fine-tuning those parts to create resonant harmonious health. David also serves as Director of Psychoacoustics at Apeiron Center in Asheville, NC where he develops sound-based tools for better mood, energy, and focus. Additionally, he’s an expert in the pharmacogenetics of the endocannabinoid system and has developed a proprietary genetic test for looking at individual response to cannabinoids. A biohacker by training and artist by nature, David enjoys working with others who have a deep passion for enjoying life.